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公开(公告)号：US20070149613A1
公开(公告)日：2007-06-28
申请号：US11603688
申请日：2006-11-21
Applicant: Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
Inventor： Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
IPC: A61K31/336
CPC classification number: C07D303/22 , C07D405/12 , C07D407/12
Abstract: The disclosure relates to a fumagillol compound which can be usefully used not only as an angiogenesis inhibiting agent showing a superior angiogenesis inhibitory effect with less toxicity, but also as a cancer metastasis inhibitor and a therapeutic agent against cancer and other various inflammatory diseases such as rheumatic disease, psoriasis, etc., and diabetic retinopathy related to angiogenesis, and also a method for preparing the same.
Abstract translation: 本公开涉及一种烟曲霉醇化合物，其不仅可以有效地用作显示出较低毒性的优异的血管发生抑制作用的血管生成抑制剂，而且可用作癌症转移抑制剂和抗癌剂等各种炎性疾病如风湿性的治疗剂 疾病，牛皮癣等，以及与血管发生有关的糖尿病性视网膜病变，以及其制备方法。
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公开(公告)号：US07087768B2
公开(公告)日：2006-08-08
申请号：US10490588
申请日：2002-06-11
Applicant: Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
Inventor： Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
IPC: C07D303/00
CPC classification number: C07D303/22 , C07D405/12 , C07D407/12
Abstract: The disclosure relates to a fumagillol compound which can be usefully used not only as an angiogenesis inhibiting agent showing a superior angeogenesis inhibitory effect with less toxicity, but also as a cancer metastasis inhibitor and a therapeutic agent against cancer and other various inflammatory diseases such as rheumatic disease, psoriasis, etc., and diabetic retinopathy related to angeogeneois, and also a method for preparing the same.
Abstract translation: 本公开涉及一种烟曲霉醇化合物，其不仅可以有效地用作具有较低毒性的显示出优异的发生形成抑制作用的血管生成抑制剂，而且可用作癌症转移抑制剂和抗癌剂等各种炎性疾病如风湿性的治疗剂 疾病，牛皮癣等，以及与异型体有关的糖尿病性视网膜病变，以及其制备方法。
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公开(公告)号：US5889148A
公开(公告)日：1999-03-30
申请号：US700449
申请日：1996-08-27
Applicant: Keun-Hyeung Lee , Sung-Yu Hong , Hyun-Sook Cho , Bok-Leul Lee , Kwang-Hoe Chung , Jeong-Hyeok Yoon , Jong-Eun Oh , Hong-Mo Moon
Inventor： Keun-Hyeung Lee , Sung-Yu Hong , Hyun-Sook Cho , Bok-Leul Lee , Kwang-Hoe Chung , Jeong-Hyeok Yoon , Jong-Eun Oh , Hong-Mo Moon
CPC classification number: C07K14/43563 , A61K38/00
Abstract: The present invention relates to novel antibiotic peptides which possess antibacterial and/or antifungal activities causing no cytotoxicity, and to antibacterial and/or antifungal agents containing said peptides as active ingredients. In accordance with the present invention, it has been discovered that a number of chemically-synthesized peptides which are derived from Tenecin, show superior antibacterial and/or antifungal activities, while causing no untoward effects, and they can be applied for the development of antibacterial and/or antifungal agents.
Abstract translation: PCT No.PCT / KR96 / 00034 Sec。 371日期：1996年8月27日 102（e）日期1996年8月27日PCT 1996年3月11日PCT公布。 出版物WO97 / 02286 日期1997年1月23日本发明涉及具有不引起细胞毒性的抗细菌和/或抗真菌活性的新型抗生素肽以及含有所述肽作为活性成分的抗细菌剂和/或抗真菌剂。 根据本发明，已经发现，从Tenecin衍生的多种化学合成的肽显示出优异的抗菌和/或抗真菌活性，同时不会产生不利影响，并且它们可用于开发抗菌剂 和/或抗真菌剂。
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公开(公告)号：US20060276512A1
公开(公告)日：2006-12-07
申请号：US11494026
申请日：2006-07-26
Applicant: Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
Inventor： Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
IPC: A61K31/4433 , A61K31/336
CPC classification number: C07D303/22 , C07D405/12 , C07D407/12
Abstract: The disclosure relates to a fumagillol compound which can be usefully used not only as an angiogenesis inhibiting agent showing a superior angiogenesis inhibitory effect with less toxicity, but also as a cancer metastasis inhibitor and a therapeutic agent against cancer and other various inflammatory diseases such as rheumatic disease, psoriasis, etc., and diabetic retinopathy related to angiogenesis, and also a method for preparing the same.
Abstract translation: 本公开涉及一种烟曲霉醇化合物，其不仅可以有效地用作显示出较低毒性的优异的血管发生抑制作用的血管生成抑制剂，而且可用作癌症转移抑制剂和抗癌剂等各种炎性疾病如风湿性的治疗剂 疾病，牛皮癣等，以及与血管发生有关的糖尿病性视网膜病变，以及其制备方法。
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