公开(公告)号：US06589548B1

公开(公告)日：2003-07-08

申请号：US09700380

申请日：2000-11-14

Applicant: Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

Inventor： Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

IPC: A61F200

CPC classification number: B82Y5/00 ,  A61K47/6927 ,  A61K47/6937

Abstract: The present invention relates to a molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect, Moreover, a high loading efficiency of hydrophilic drugs can be achieved.

Abstract translation: 本发明涉及通过共价键将待释放的分子与可生物降解的聚酯聚合物共轭而构成的分子持续控制释放系统及其制备方法。 根据本发明，该系统可以配制成微球，纳米颗粒或薄膜。 可以调节上述体系的分子释放速率与生物可降解聚酯聚合物的化学降解速率成比例，导致释放的接近零级动力学特征，而不发生爆裂效应。此外，亲水性药物的高负载效率可以 实现。

公开(公告)号：US6140363A

公开(公告)日：2000-10-31

申请号：US312405

申请日：1999-05-14

Applicant: Eun Mi Hur ,  Young Bong Choi ,  Changwon Park ,  Jongsung Lee ,  Dongsu Park ,  Yungdae Yun ,  Keun Hyeung Lee ,  Jong-Eun Oh ,  Soon Choul Ahn ,  Hyun Sun Lee ,  Jong Sok Ahn ,  Soo Il Jung

Inventor： Eun Mi Hur ,  Young Bong Choi ,  Changwon Park ,  Jongsung Lee ,  Dongsu Park ,  Yungdae Yun ,  Keun Hyeung Lee ,  Jong-Eun Oh ,  Soon Choul Ahn ,  Hyun Sun Lee ,  Jong Sok Ahn ,  Soo Il Jung

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/216 ,  A61K36/18 ,  A61P1/16 ,  A61P7/02 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P31/18 ,  A61P35/02 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  A61P43/00 ,  A61K31/235

CPC classification number: A61K31/00

Abstract: The present invention relates to use of rosmarinic acid and/or derivatives thereof as immunosuppressive agents and/or as inhibitor of SH2 domain function. Disclosed in the present invention is that rosmarinic acid and derivatives thereof specifically inhibit the binding of ligand peptides to Lck SH2 domain, disturb the Lck-mediated signal transduction in T cells, also inhibit cytoline gene expression, and suppress immune responses in the transplanted tissue. These activities of rosmarinic acid and derivatives thereof support their applicability to treatment, prevention and/or diagnosis of graft rejection, GVHD, autoimmune diseases, inflammatory diseases, etc.

Abstract translation: 本发明涉及迷迭香酸和/或其衍生物作为免疫抑制剂和/或作为SH2结构域功能的抑制剂的用途。 在本发明中公开的是，迷迭香酸及其衍生物特异性抑制配体肽与Lck SH2结构域的结合，扰乱T细胞中的Lck介导的信号转导，也抑制细胞基因表达，并抑制移植组织中的免疫应答。 迷迭香酸及其衍生物的这些活性支持其适用于治疗，预防和/或诊断移植排斥反应，GVHD，自身免疫疾病，炎性疾病等。

公开(公告)号：US07163698B2

公开(公告)日：2007-01-16

申请号：US10423536

申请日：2003-04-25

Applicant: Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

Inventor： Jong Eun Oh ,  Keon Hyoung Lee ,  Tae Gwan Park ,  Yoon Sung Nam

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/50

CPC classification number: B82Y5/00 ,  A61K47/6927 ,  A61K47/6937

Abstract: The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.

Abstract translation: 本发明涉及通过共价键与待分解的分子与可生物降解的聚酯聚合物共轭构成的分子持续控制释放体系及其制备方法。 根据本发明，该系统可以配制成微球，纳米颗粒或薄膜。 可以调节上述体系的分子释放速率与可生物降解的聚酯聚合物的化学降解速率成比例，导致释放的接近零级动力学特征，而不发生爆裂效应。 此外，可以实现亲水药物的高负载效率。

公开(公告)号：US5889148A

公开(公告)日：1999-03-30

申请号：US700449

申请日：1996-08-27

Applicant: Keun-Hyeung Lee ,  Sung-Yu Hong ,  Hyun-Sook Cho ,  Bok-Leul Lee ,  Kwang-Hoe Chung ,  Jeong-Hyeok Yoon ,  Jong-Eun Oh ,  Hong-Mo Moon

Inventor： Keun-Hyeung Lee ,  Sung-Yu Hong ,  Hyun-Sook Cho ,  Bok-Leul Lee ,  Kwang-Hoe Chung ,  Jeong-Hyeok Yoon ,  Jong-Eun Oh ,  Hong-Mo Moon

IPC: A61K38/00 ,  A61P31/04 ,  C07K14/435 ,  C07K5/00 ,  C07K7/00 ,  C07K15/00

CPC classification number: C07K14/43563 ,  A61K38/00

Abstract: The present invention relates to novel antibiotic peptides which possess antibacterial and/or antifungal activities causing no cytotoxicity, and to antibacterial and/or antifungal agents containing said peptides as active ingredients. In accordance with the present invention, it has been discovered that a number of chemically-synthesized peptides which are derived from Tenecin, show superior antibacterial and/or antifungal activities, while causing no untoward effects, and they can be applied for the development of antibacterial and/or antifungal agents.

Abstract translation: PCT No.PCT / KR96 / 00034 Sec。 371日期：1996年8月27日 102（e）日期1996年8月27日PCT 1996年3月11日PCT公布。 出版物WO97 / 02286 日期1997年1月23日本发明涉及具有不引起细胞毒性的抗细菌和/或抗真菌活性的新型抗生素肽以及含有所述肽作为活性成分的抗细菌剂和/或抗真菌剂。 根据本发明，已经发现，从Tenecin衍生的多种化学合成的肽显示出优异的抗菌和/或抗真菌活性，同时不会产生不利影响，并且它们可用于开发抗菌剂 和/或抗真菌剂。