-
1.发明授权YLMPO1 gene derived from yarrowia lipolytica and a process for preparing a glycoprotein not being mannosylphosphorylated by using a mutated yarrowia lipolytica in which YLMPO1 gene is disrupted 有权衍生自解脂耶氏酵母的YLMPO1基因和通过使用其中YLMPO1基因被破坏的突变的解脂耶氏酵母的解脂耶氏酵母制备不被甘露糖基磷酸化的糖蛋白的方法公开(公告)号：US08003349B2
公开(公告)日：2011-08-23
申请号：US12598887
申请日：2007-11-30
申请人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
发明人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
CPC分类号： C12N15/815 , C12N9/1081
摘要： The present invention relates to a novel YlMPO1 gene which plays an important role in mannosylphosphorylation of an industrial yeast Yarrowia lipolytica, and to a method for preparing a host system capable of producing recombinant glycoproteins free of mannosylphosphate by disruption of the gene. The mannosylphosphorylation is suppressed by the disruption of YlMPO1 gene according to the present invention, thereby achieving humanization of glycosylation pathway of Yarrowia lipolytica.
摘要翻译： 本发明涉及一种在工业酵母解脂耶氏酵母（Yarrowia lipolytica）的甘露糖基磷酸化中起重要作用的新型YlMPO1基因，以及能够通过破坏基因产生不含磷酸甘露糖基的重组糖蛋白的宿主系统的方法。 通过根据本发明的YlMPO1基因的破坏来抑制甘露糖基磷酸化，从而实现解脂耶氏酵母的糖基化途径的人源化。
-
2.发明申请Novel YLMPO1 Gene Derived From Yarrowia Lipolytica and A Process for Preparing a Glycoprotein Not Being Mannosylphosphorylated By Using a Mutated Yarrowia Lipolytica in Which YLMPO1 Gene is Disrupted 有权来自解脂耶氏酵母的新型YLMPO1基因和通过使用其中YLMPO1基因被破坏的突变型耶氏酵母属（Larrowia Lipolytica）而不是正羰基磷酸化的糖蛋白的制备方法公开(公告)号：US20100227362A1
公开(公告)日：2010-09-09
申请号：US12598887
申请日：2007-11-30
申请人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
发明人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
CPC分类号： C12N15/815 , C12N9/1081
摘要： The present invention relates to a novel YlMPOl gene which plays an important role in mannosylphosphorylation of an industrial yeast Yarrowia lipolytica, and to a method for preparing a host system capable of producing recombinant glycoproteins free of mannosylphosphate by disruption of the gene. The mannosylphosphorylation is suppressed by the disruption of YlMPOl gene according to the present invention, thereby achieving humanization of glycosylation pathway of Yarrowia lipolytica.
摘要翻译： 本发明涉及在工业酵母解脂耶氏酵母解脂耶氏酵母的甘油糖基磷酸化中起重要作用的新型YlMPO1基因，以及能够通过破坏基因产生不含磷酸甘露糖基的重组糖蛋白的宿主系统的方法。 通过根据本发明的YlMPO1基因的破坏来抑制甘露糖基磷酸化，从而实现解脂耶氏酵母的糖基化途径的人源化。
-
搜索结果
2 条记录 (耗时 0.013 秒)
