公开(公告)号：US20210285944A1

公开(公告)日：2021-09-16

申请号：US17198823

申请日：2021-03-11

申请人： Srikanth Singamaneni ,  Rohit Gupta ,  Jingyi Luan ,  Shantanu Chakrabartty ,  Erica Scheller ,  Jeremiah Morrissey ,  Yixuan Wang ,  Zheyu Wang

发明人： Srikanth Singamaneni ,  Rohit Gupta ,  Jingyi Luan ,  Shantanu Chakrabartty ,  Erica Scheller ,  Jeremiah Morrissey ,  Yixuan Wang ,  Zheyu Wang

IPC分类号： G01N33/543

摘要： The present disclosure is directed to refreshable biosensors and methods for synthesizing and refreshing same. In some embodiments, the refreshable biosensor comprises a plasmonic nanoparticle and a biorecognition element, wherein the biorecognition element is encapsulated with at least one of an organosilica polymer layer or a metal organic framework (MOF).

公开(公告)号：US20120184451A1

公开(公告)日：2012-07-19

申请号：US13309852

申请日：2011-12-02

申请人： Srikanth Singamaneni ,  Evan Kharasch ,  Jeremiah Morrissey ,  Chang Hee Lee

发明人： Srikanth Singamaneni ,  Evan Kharasch ,  Jeremiah Morrissey ,  Chang Hee Lee

IPC分类号： G01N21/55 ,  C40B30/04 ,  C40B40/00 ,  C40B40/18 ,  B82Y15/00

CPC分类号： G01N33/54346 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y40/00 ,  G01N21/554 ,  G01N21/658 ,  G01N33/54373 ,  G01N33/57438 ,  G01N2201/02

摘要： Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.

摘要翻译： 用于特定蛋白质的天然和/或合成抗体粘附到纳米颗粒上。 将纳米颗粒粘附到底物上，将底物暴露于可含有特定蛋白质的样品。 然后用表面增强拉曼散射技术和/或局部表面等离子体共振技术测试底物以量化样品中特定蛋白质的量。