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1.发明授权3, 5, and/or 6 substituted analogues of swainsonine processes for their preparation and their use as therapeutic agents 失效3，5和/或6种用于其制备的丝氨酸过程的取代类似物及其作为治疗剂的用途
公开(公告)号：US6048870A
公开(公告)日：2000-04-11
申请号：US941689
申请日：1997-10-01
申请人： Rajan Shah , Jeremy Carver , Jose Marino-Albernas , Igor Tvaroska , Francois Tropper , James Dennis
发明人： Rajan Shah , Jeremy Carver , Jose Marino-Albernas , Igor Tvaroska , Francois Tropper , James Dennis
IPC分类号： C07D491/147 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4745 , A61K31/5025 , A61K31/542 , A61P31/00 , A61P35/00 , A61P37/04 , C07D471/04 , C07D471/10 , C07D471/14 , C07D471/16 , C07D491/20 , C07D495/14 , C07D498/14 , C07D513/16 , A61K31/435
CPC分类号： C07D471/04
摘要： The invention relates to novel 3, 5, and/or 6 swainsonine analogues, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.
摘要翻译： 本发明涉及新的3,5和/或6种磺胺类似物，其制备方法及其作为治疗剂的用途。 本发明还涉及含有化合物及其作为治疗剂的用途的药物组合物。
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2.发明授权Mannosidase inhibitors, process for their preparation and their use as therapeutic agents 失效甘露糖苷酶抑制剂，其制备方法及其作为治疗剂的用途
公开(公告)号：US5773239A
公开(公告)日：1998-06-30
申请号：US568127
申请日：1995-12-06
申请人： Jeremy Carver , James Wilson Dennis , Rajan Shah
发明人： Jeremy Carver , James Wilson Dennis , Rajan Shah
IPC分类号： C07D207/12 , C07D491/04 , C12Q1/02 , C12Q1/00 , C12Q1/34 , C12Q1/48
CPC分类号： C07D491/04 , C07D207/12
摘要： The invention relates to novel mannosidase inhibitors, processes for their preparation and their use as therapeutic agents. The invention also relates to the use of compounds of the formula II as described herein as prodrugs.
摘要翻译： 本发明涉及新型甘露糖苷酶抑制剂，其制备方法及其作为治疗剂的用途。 本发明还涉及本文所述的式II化合物作为前药的用途。
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公开(公告)号：US06415234B1
公开(公告)日：2002-07-02
申请号：US09365024
申请日：1999-08-02
申请人： Isabelle Andre , Igor Tvaroska , Jeremy Carver
发明人： Isabelle Andre , Igor Tvaroska , Jeremy Carver
IPC分类号： G01N3100
CPC分类号： C07H1/00
摘要： The invention relates to the design of inhibitors for glycosyltransferases, and in particular to computer-implemented methods for designing the inhibitors. The invention also relates to compositions and treatments using the inhibitors.
摘要翻译： 本发明涉及糖基转移酶抑制剂的设计，特别涉及用于设计抑制剂的计算机实施方法。 本发明还涉及使用抑制剂的组合物和治疗。
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公开(公告)号：US5962467A
公开(公告)日：1999-10-05
申请号：US897656
申请日：1997-07-21
申请人： Jeremy Carver , Rajan Shah
发明人： Jeremy Carver , Rajan Shah
IPC分类号： A61K31/435 , A61P31/00 , C07D471/04 , C07D491/14
CPC分类号： C07D471/04 , C07D491/14
摘要： The invention relates to novel mannosidase inhibitors, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics
摘要翻译： 本发明涉及新型甘露糖苷酶抑制剂，其制备方法及其作为治疗剂的用途。 本发明还涉及含有化合物及其作为治疗剂的用途的药物组合物
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5.发明授权
公开(公告)号：US5650413A
公开(公告)日：1997-07-22
申请号：US474077
申请日：1995-06-07
申请人： Jeremy Carver , Rajan Shah
发明人： Jeremy Carver , Rajan Shah
IPC分类号： A61K31/435 , A61P31/00 , C07D471/04 , C07D491/14
CPC分类号： C07D471/04 , C07D491/14
摘要： The invention relates to novel mannosidase inhibitors, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.
摘要翻译： 本发明涉及新型甘露糖苷酶抑制剂，其制备方法及其作为治疗剂的用途。 本发明还涉及含有化合物及其作为治疗剂的用途的药物组合物。
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