公开(公告)号：US20050118074A1

公开(公告)日：2005-06-02

申请号：US11024158

申请日：2004-12-28

Applicant: Allyn Hubbard ,  Samesh Kale ,  Scott Rollins ,  Jeremy Springhorn ,  Stephen Squinto ,  Prasad Akkapeddi

Inventor： Allyn Hubbard ,  Samesh Kale ,  Scott Rollins ,  Jeremy Springhorn ,  Stephen Squinto ,  Prasad Akkapeddi

IPC: B01J19/00 ,  B81B3/00 ,  C40B60/14 ,  C40B70/00 ,  G01N35/10 ,  B01L3/02

CPC classification number: G01N35/1074 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00378 ,  B01J2219/00547 ,  C40B60/14 ,  C40B70/00 ,  G01N2035/1039 ,  Y10T436/2575

Abstract: In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween. The handling system enables a method for storing and dispensing liquids including drawing a liquid sample into the channels either by capillary action, vacuum, electoosmotic flow, a minipump or any combination thereof, storing the liquid sample into the cartridge, and dispensing the liquid sample.

Abstract translation: 在液体处理系统中，该液体处理系统包括液体处理基板，该液体处理基板具有用于在所述基板中传导液体样品的多个通道，其中所述通道终止于所述基板的外表面中的多个出口，用于转移一定数量的液体样品 。 处理系统还包括具有对应于通道的多个可分离盒的液体存储和分配基板，每个盒终止于包括玻璃，硅和压电物质的层叠体的微电子机械系统（MEMS）。 处理系统还包括液体检测系统，其包括发光二极管和光检测器，其中每个通道包括与相应的墨盒连通的储存器，其在其间形成界面。 处理系统实现了一种用于存储和分配液体的方法，包括通过毛细管作用，真空，电渗流，微型泵或其任何组合将液体样品拉入通道，将液体样品储存在盒中并分配液体样品。