公开(公告)号：US20180231536A1

公开(公告)日：2018-08-16

申请号：US15952958

申请日：2018-04-13

申请人： Theranos IP Company, LLC

发明人： Tammy BURD ,  Ian GIBBONS ,  Elizabeth A. HOLMES ,  Gary FRENZEL ,  Anthony Joseph NUGENT

IPC分类号： G01N33/53 ,  G01N35/10 ,  A61B5/15 ,  G01N35/02 ,  G01N35/00 ,  G01N33/94 ,  G01N33/68 ,  G01N33/574 ,  G01N33/569 ,  G01N33/543 ,  G01N1/38 ,  B01L9/00 ,  B01L7/00 ,  B01L3/00 ,  B01L3/02 ,  B01J19/00 ,  A61B5/151 ,  A61B10/00 ,  A61B10/02

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20170362557A1

公开(公告)日：2017-12-21

申请号：US15536584

申请日：2015-12-15

申请人： NOVELLUSDX LTD.

发明人： Yehoshua SHEINMAN ,  Revital SHARIVKIN ,  Merav BELENKOVICH

IPC分类号： C12M1/32 ,  C12M1/18 ,  C40B60/08 ,  C12M3/00 ,  C12M1/26

CPC分类号： C12M33/06 ,  B01J2219/00351 ,  B01J2219/00369 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/00743 ,  C12M1/18 ,  C12M3/00 ,  C12M33/14 ,  C40B60/08

摘要： The present disclosure provides systems, devices and methods for seeding cells or sets of molecules on a substrate by utilizing a seeding mesh, to obtain an essentially homogenous patterned seeding of the cells or sets of molecules on the mesh.

公开(公告)号：US20170120250A1

公开(公告)日：2017-05-04

申请号：US15319365

申请日：2015-08-03

申请人： GenCell Biosystems Ltd.

发明人： Brian Barrett ,  Noel Sirr ,  Brian Chawke ,  Kieran Curran ,  John Daly

IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/68 ,  B01J19/00

CPC分类号： B01L7/52 ,  B01J19/0046 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00466 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2300/021 ,  B01L2300/044 ,  C12Q1/6806

摘要： Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple CLC reaction wells; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each CLC reaction well of the thermal chip module.

公开(公告)号：US20170016904A1

公开(公告)日：2017-01-19

申请号：US15217360

申请日：2016-07-22

申请人： Theranos, Inc.

发明人： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC分类号： G01N33/574 ,  G01N35/10 ,  G01N35/02 ,  G01N35/00 ,  G01N33/543

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20160266108A1

公开(公告)日：2016-09-15

申请号：US15160491

申请日：2016-05-20

申请人： Theranos, Inc.

发明人： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC分类号： G01N33/543 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20160161513A1

公开(公告)日：2016-06-09

申请号：US14963030

申请日：2015-12-08

申请人： Theranos, Inc.

发明人： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC分类号： G01N33/94 ,  G01N35/10 ,  G01N33/543

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US09314764B2

公开(公告)日：2016-04-19

申请号：US13188337

申请日：2011-07-21

申请人： Robert Hess ,  John Linton ,  Tanya S. Kanigan ,  Colin Brenan ,  Can Ozbal

发明人： Robert Hess ,  John Linton ,  Tanya S. Kanigan ,  Colin Brenan ,  Can Ozbal

IPC分类号： G01N1/10 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N30/46 ,  B01L99/00 ,  C40B60/14 ,  G01N30/60 ,  G01N30/82 ,  G01N30/84

CPC分类号： B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/0036 ,  B01J2219/00369 ,  B01J2219/00387 ,  B01J2219/00389 ,  B01J2219/00423 ,  B01J2219/0043 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00673 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/0268 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5085 ,  B01L3/50857 ,  B01L99/00 ,  B01L2200/0657 ,  B01L2300/0845 ,  C12M23/12 ,  C40B60/14 ,  G01N30/466 ,  G01N30/6091 ,  G01N30/6095 ,  G01N30/82 ,  G01N2030/8417

摘要： The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

摘要翻译： 本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。 本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。 本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。 此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。

公开(公告)号：US09012375B2

公开(公告)日：2015-04-21

申请号：US14076037

申请日：2013-11-08

申请人： CSIR

发明人： Neil Emans

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00376 ,  B01J2219/00387 ,  B01J2219/00533 ,  B01L3/0262 ,  B01L2300/0819 ,  B01L2300/0838

摘要： The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing an array of reagent composition containing capillary tubes (22) arranged alongside one another from an inoperative position to an operative position in which open ends of the capillary tubes (22) simultaneously impinge against a substrate and thereafter displacing the array of tubes (22) from the operative position back to the inoperative position. The invention extends to a printing apparatus (10), a method of printing a layered array of spots of reagent compositions, a method of introducing reagent compositions into the tubes, a reagent introducing device for introducing reagent compositions into the tubes and a printing installation which includes the printing apparatus (10) and the reagent introducing device.

公开(公告)号：US20140249057A1

公开(公告)日：2014-09-04

申请号：US14169992

申请日：2014-01-31

申请人： APPLIED BIOSYSTEMS, LLC

发明人： Sergey V. Ermakov

IPC分类号： B01L3/00 ,  B01L7/00

CPC分类号： B01L3/50273 ,  B01J19/0046 ,  B01J2219/00367 ,  B01J2219/00369 ,  B01J2219/00389 ,  B01J2219/00439 ,  B01J2219/00441 ,  B01J2219/00448 ,  B01J2219/0045 ,  B01J2219/00675 ,  B01J2219/00695 ,  B01J2219/00722 ,  B01L3/502738 ,  B01L3/502784 ,  B01L3/502792 ,  B01L7/52 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/168 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0448 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0688 ,  B82Y30/00 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14 ,  F15D1/00 ,  F15D1/06 ,  Y10T137/0391 ,  Y10T137/206 ,  Y10T137/2224 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present teachings provide a fluid processing device adapted to produce different oligomers in a plurality of respective reaction sites. The fluid processing device can comprise a first manifold for delivering reactants to the plurality of reaction sites, and a second manifold for removing waste from, and optionally delivering wash fluid to, the plurality of reaction sites. Surface tension control valves can be disposed in fluid communication with the first manifold and can selectively allow reactants and/or fluids into the reaction sites. A method of making oligonucleotides is also provided.

摘要翻译： 本教导提供适于在多个相应反应位点中产生不同低聚物的流体处理装置。 流体处理装置可以包括用于将反应物递送到多个反应部位的第一歧管，以及用于从多个反应部位除去废物并且可选地输送洗涤流体的第二歧管。 表面张力控制阀可以设置成与第一歧管流体连通并且可以选择性地允许反应物和/或流体进入反应位置。 还提供了制备寡核苷酸的方法。

公开(公告)号：US08663577B2

公开(公告)日：2014-03-04

申请号：US12385755

申请日：2009-04-17

申请人： Hiroshi Aoki ,  Masaki Torimura ,  Hiroaki Tao ,  Takashi Ikeda

发明人： Hiroshi Aoki ,  Masaki Torimura ,  Hiroaki Tao ,  Takashi Ikeda

IPC分类号： B01L3/00

CPC分类号： B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/0268 ,  B01L9/54 ,  B01L9/547 ,  B01L2200/022 ,  B01L2300/0838 ,  G01N35/1067 ,  G01N35/1074 ,  Y10T436/2575

摘要： A spotter that includes a plurality of spotting heads, each of the plurality of spotting heads having a discharging portion at a tip portion, the plurality of spotting heads form an m×n array (m, n>1) with m spotting heads arranged lengthwise and n spotting heads arranged crosswise; and a pitch varying mechanism configured to vary an array pitch of the plurality of spotting heads arrayed in a lengthwise direction and an array pitch of the plurality of spotting heads arrayed in a crosswise direction.

摘要翻译： 一种检测器，包括多个点样头，所述多个点样头中的每一个具有在尖端部分的排出部分，所述多个点样头形成m×n阵列（m，n> 1），其中m个点样头纵向排列 并且n个点头交叉排列; 以及变桨机构，被配置为改变沿横向方向排列的多个点样头的阵列间距和沿横向排列的多个点样头的阵列间距。