公开(公告)号：US08316721B2

公开(公告)日：2012-11-27

申请号：US12911478

申请日：2010-10-25

申请人： Bo Ki Hong ,  Kook Il Han ,  Ji Yeon Park ,  Byeong Heon Jeong ,  Sang Yeoul Ahn

发明人： Bo Ki Hong ,  Kook Il Han ,  Ji Yeon Park ,  Byeong Heon Jeong ,  Sang Yeoul Ahn

IPC分类号： G01N3/20

CPC分类号： G01N3/20 ,  G01N2203/0282

摘要： The present invention provides an apparatus and method for non-destructive measurement of bending stiffness of a gas diffusion layer (GDL) for a fuel cell by measuring a sagging length of a GDL sample, which can be used for a fuel cell, without damaging or destroying the GDL sample.

摘要翻译： 本发明提供了一种用于燃料电池的气体扩散层（GDL）的弯曲刚度的无损测量的装置和方法，其通过测量可用于燃料电池的GDL样品的下垂长度，而不损坏或 破坏GDL样本。

公开(公告)号：US20050203145A1

公开(公告)日：2005-09-15

申请号：US10970046

申请日：2004-10-20

申请人： Young-Dae Gong ,  Hyae-Gyeong Cheon ,  Young-Sik Cho ,  Jin-Soo Seo ,  Jong-Yeon Hwang ,  Ji-Yeon Park ,  Sung-eun Yoo

发明人： Young-Dae Gong ,  Hyae-Gyeong Cheon ,  Young-Sik Cho ,  Jin-Soo Seo ,  Jong-Yeon Hwang ,  Ji-Yeon Park ,  Sung-eun Yoo

IPC分类号： C07D311/70 ,  A61K31/352 ,  A61K31/353 ,  A61K31/36 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/4433 ,  A61P1/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07B61/00 ,  C07D311/76 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D49/02 ,  C07D45/02

CPC分类号： C07D311/70 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

摘要： When a multi-step process reaction is carried out in a solution, it generally requires several treatments and purification procedures to go through with after the reaction, however, the inventive method for preparing 2,2′-disubstituted-3,4-dihydro-7,8-disubstituted-6-amino benzopyran derivative using a solid-phased synthetic method simplifies the treatment and purification procedures after the reaction, which makes possible to efficiently construct numerous drug-like libraries. In particular, since the inventive method of the present invention comprises the steps of introducing a carbonate linker of formula 2 into Wang resin used as a common solid support (Step 1); synthesizing various benzopyran in a carbamate form of formula 3 as a key intermediate by reacting various amino benzopyran derivatives with the carbamate resin of formula 2 (Step 2); synthesizing 2,2′-disubstituted-3,4-2H-6-substituted benzopyran resin of formula 4 (Step 3); and synthesizing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative of formula 1 using a dichloromethane solution containing TFA or an organic solvent containing an organic acid, the inventive method is capable of efficiently synthesizing various 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivatives. Consequently, the present invention has developed a new technique for constructing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran library using a solid-phase parallel synthetic method and makes increased the applicability of combinatorial chemical synthetic method. Further, 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative prepared by the inventive method has a high inhibitory effect to 5-lipoxygenase (5-LO) activity, and therefore, can be effectively used for developing a new propylactic or therapeutic drug for leukotriene activation-related diseases such as chronic inflammation, rheumatic arthritis, colitis, asthma and psoriasis.

公开(公告)号：USD790207S1

公开(公告)日：2017-06-27

申请号：US29526319

申请日：2015-05-08

申请人： Ji Yeon Park

设计人： Ji Yeon Park

公开(公告)号：US20110314928A1

公开(公告)日：2011-12-29

申请号：US12911478

申请日：2010-10-25

申请人： Bo Ki Hong ,  Kook Il Han ,  Ji Yeon Park ,  Byeong Heon Jeong ,  Sang Yeoul Ahn

发明人： Bo Ki Hong ,  Kook Il Han ,  Ji Yeon Park ,  Byeong Heon Jeong ,  Sang Yeoul Ahn

IPC分类号： G01N3/20

CPC分类号： G01N3/20 ,  G01N2203/0282

摘要： The present invention provides an apparatus and method for non-destructive measurement of bending stiffness of a gas diffusion layer (GDL) for a fuel cell by measuring a sagging length of a GDL sample, which can be used for a fuel cell, without damaging or destroying the GDL sample.

摘要翻译： 本发明提供了一种用于燃料电池的气体扩散层（GDL）的弯曲刚度的无损测量的装置和方法，其通过测量可用于燃料电池的GDL样品的下垂长度，而不损坏或 破坏GDL样本。

公开(公告)号：US20120088179A1

公开(公告)日：2012-04-12

申请号：US12952068

申请日：2010-11-22

申请人： Bu Ho Kwak ,  Bo Ki Hong ,  Kook Il Han ,  Ji Yeon Park

发明人： Bu Ho Kwak ,  Bo Ki Hong ,  Kook Il Han ,  Ji Yeon Park

IPC分类号： H01M8/24

CPC分类号： H01M8/248 ,  H01M8/04089 ,  H01M8/04753 ,  H01M2008/1095

摘要： A method of clamping a fuel cell stack includes a stack preliminary clamping step, a stack pre-treatment step of performing a gas flow rate variation cycle or a clamping pressure variation cycle, wherein the gas flow rate variation cycle repeatedly changes a flow rate of a gas supplied to an anode and a cathode included in the preliminarily clamped stack, and wherein the clamping pressure variation cycle repeatedly increases and decreases the clamping pressure by pressurization and pressure release of the preliminarily clamped stack using the pressure tool, and a stack main clamping step of correcting a variation in clamping pressure occurring due to a variation in thickness of a gas diffusion layer to mainly clamp the stack after the stack pre-treatment step.

摘要翻译： 夹持燃料电池堆的方法包括堆叠预备夹紧步骤，执行气体流量变化循环或夹紧压力变化循环的堆叠预处理步骤，其中气体流量变化循环重复地改变燃料电池堆的流量 气体供应到预先夹紧的堆叠中包括的阳极和阴极，并且其中夹紧压力变化循环通过使用压力工具的预先夹紧的堆叠的加压和压力释放重复地增加和减小夹紧压力，并且堆叠主夹紧步骤 校正由于气体扩散层的厚度变化而产生的夹紧压力的变化，以在堆叠预处理步骤之后主要夹紧堆叠。

公开(公告)号：US07368575B2

公开(公告)日：2008-05-06

申请号：US10970046

申请日：2004-10-20

申请人： Young-Dae Gong ,  Hyae-Gyeong Cheon ,  Young-Sik Cho ,  Jin-Soo Seo ,  Jong-Yeon Hwang ,  Ji-Yeon Park ,  Sung-Eun Yoo

发明人： Young-Dae Gong ,  Hyae-Gyeong Cheon ,  Young-Sik Cho ,  Jin-Soo Seo ,  Jong-Yeon Hwang ,  Ji-Yeon Park ,  Sung-Eun Yoo

IPC分类号： C07D311/00 ,  C07D405/00

CPC分类号： C07D311/70 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

摘要： When a multi-step process reaction is carried out in a solution, it generally requires several treatments and purification procedures to go through with after the reaction, however, the inventive method for preparing 2,2′-disubstituted-3,4-dihydro-7,8-disubstituted-6-amino benzopyran derivative using a solid-phased synthetic method simplifies the treatment and purification procedures after the reaction, which makes possible to efficiently construct numerous drug-like libraries. In particular, since the inventive method of the present invention comprises the steps of introducing a carbonate linker of formula 2 into Wang resin used as a common solid support (Step 1); synthesizing various benzopyran in a carbamate form of formula 3 as a key intermediate by reacting various amino benzopyran derivatives with the carbamate resin of formula 2 (Step 2); synthesizing 2,2′-disubstituted-3,4-2H-6-substituted benzopyran resin of formula 4 (Step 3); and synthesizing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative of formula 1 using a dichloromethane solution containing TFA or an organic solvent containing an organic acid, the inventive method is capable of efficiently synthesizing various 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivatives.Consequently, the present invention has developed a new technique for constructing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran library using a solid-phase parallel synthetic method and makes increased the applicability of combinatorial chemical synthetic method. Further, 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative prepared by the inventive method has a high inhibitory effect to 5-lipoxygenase (5-LO) activity, and therefore, can be effectively used for developing a new propylactic or therapeutic drug for leukotriene activation-related diseases such as chronic inflammation, rheumatic arthritis, colitis, asthma and psoriasis.