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公开(公告)号：US07939527B2
公开(公告)日：2011-05-10
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/516 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
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2.发明申请PROCESS FOR THE PREPARATION OF NONPEPTIDE SUBSTITUTED SPIROBENZOAZEPINE DERIVATIVES 审中-公开制备非取代的SPIROBENZOAZEPINE衍生物的方法公开(公告)号：US20090105220A1
公开(公告)日：2009-04-23
申请号：US12341712
申请日：2008-12-22
申请人： Xiaohu Deng , Birdella Kenney , Jimmy T. Liang , Neelakandha Mani , Frank J. Villani , Fan Zhang-Plasket , Hua Zhong
发明人： Xiaohu Deng , Birdella Kenney , Jimmy T. Liang , Neelakandha Mani , Frank J. Villani , Fan Zhang-Plasket , Hua Zhong
IPC分类号： A61K31/55 , C07D223/32 , C07C233/64
CPC分类号： C07C233/81 , C07D223/32
摘要： Novel spirobenzoazepine compounds, novel processes for the preparation of nonpeptide substituted spirobenzoazepine derivatives, and novel processes for the preparation of intermediates in the preparation of such derivatives. Novel intermediates in the preparation of nonpeptide substituted spirobenzoazepine derivatives.
摘要翻译： 新型螺苯并氮杂化合物，用于制备非肽取代的螺苯并氮杂衍生物的新方法，以及制备这些衍生物的中间体的新方法。 新型中间体在制备非肽取代的螺苯并氮杂衍生物。
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公开(公告)号：US20070260057A1
公开(公告)日：2007-11-08
申请号：US11744340
申请日：2007-05-04
申请人： Xiaohu Deng , Jimmy T. Liang , Neelakandha Mani
发明人： Xiaohu Deng , Jimmy T. Liang , Neelakandha Mani
IPC分类号： C07D487/02
CPC分类号： C07D487/04 , C07D317/16 , C07D405/06
摘要： The present invention is directed to novel processes for the preparation of fused pyrazole compounds, useful for the treatment of disorders and conditions mediated by serotonin receptor activity.
摘要翻译： 本发明涉及制备用于治疗由5-羟色胺受体活性介导的病症和病症的稠合吡唑化合物的新方法。
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4.发明申请Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20110159563A1
公开(公告)日：2011-06-30
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： C12N9/99 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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公开(公告)号：US07947833B2
公开(公告)日：2011-05-24
申请号：US11928268
申请日：2007-10-30
IPC分类号： C07D241/36
CPC分类号： C07D241/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： Certain methods that are useful in the preparation of amidophenyl-sulfonylamino-quinoxaline compounds are disclosed. The compounds are of the class of quinoxaline sulfonamides and constitute CCK2 receptor modulators, useful in the treatment of gastrointestinal diseases.
摘要翻译： 公开了可用于制备酰氨基 - 磺酰基氨基 - 喹喔啉化合物的某些方法。 这些化合物是喹喔啉磺酰胺类，构成CCK2受体调节剂，可用于治疗胃肠疾病。
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公开(公告)号：US07897771B2
公开(公告)日：2011-03-01
申请号：US12496866
申请日：2009-07-02
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： C07D417/02 , A01N43/42
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号：US07288651B2
公开(公告)日：2007-10-30
申请号：US10910983
申请日：2004-08-04
IPC分类号： C07D487/00 , C07D413/00
CPC分类号： C04B35/632 , C07D241/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： Certain methods are disclosed that are useful in the preparation of CCK2 active amidophenyl-sulfonylamino-quinoxaline compounds of the formula: wherein R1, R2, Ra and Rb are defined.
摘要翻译： 公开了可用于制备下式的CCK 2活性氨基苯磺酰氨基喹喔啉化合物的方法：其中R 1，R 2，R 2， / SUP>和R＆lt; b＆gt;定义。
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公开(公告)号：US20120142928A1
公开(公告)日：2012-06-07
申请号：US13389790
申请日：2010-08-11
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Inhibitors of Cathepsin S enzyme and their synthetic processes.
摘要翻译： 组织蛋白酶S酶抑制剂及其合成过程。
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公开(公告)号：US07915404B2
公开(公告)日：2011-03-29
申请号：US11744340
申请日：2007-05-04
申请人： Xiaohu Deng , Jimmy T. Liang , Neelakandha Mani
发明人： Xiaohu Deng , Jimmy T. Liang , Neelakandha Mani
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D317/16 , C07D405/06
摘要： The present invention is directed to novel processes for the preparation of fused pyrazole compounds, useful for the treatment of disorders and conditions mediated by serotonin receptor activity.
摘要翻译： 本发明涉及制备用于治疗由5-羟色胺受体活性介导的病症和病症的稠合吡唑化合物的新方法。
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公开(公告)号：US20090270370A1
公开(公告)日：2009-10-29
申请号：US12496866
申请日：2009-07-02
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , A61K31/55 , A61K31/4162
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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