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公开(公告)号:US20070218098A1
公开(公告)日:2007-09-20
申请号:US10561800
申请日:2004-06-25
申请人: Dieter Reif , Fabian Peters , Frank Palm , Joachim Wittner
发明人: Dieter Reif , Fabian Peters , Frank Palm , Joachim Wittner
CPC分类号: A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2002/2839 , A61F2002/30011 , A61F2002/30062 , A61F2002/30224 , A61F2002/3024 , A61F2002/30261 , A61F2002/30263 , A61F2002/30281 , A61F2002/30968 , A61F2210/0004 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2230/0086 , A61F2250/0023 , A61F2310/00293 , A61L24/0036 , A61L24/0068 , A61L27/12 , A61L27/56 , A61L2430/02 , B33Y80/00 , C04B35/447 , C04B35/6262 , C04B35/62695 , C04B38/0064 , C04B2111/00836 , C04B2235/3208 , C04B2235/3212 , C04B2235/5427 , C04B2235/5436 , C04B2235/5472 , C04B2235/77 , C04B2235/94 , C04B38/0051 , C04B38/0645
摘要: The invention relates to a bone formation agent of porous calcium phosphate having an isotropic sintered structure and, between the particles of the calcium phosphate, statistically distributed pores in a plurality of discrete size ranges. The bone formation agent has at least two, preferably three, discrete pore size distributions. Its porosity has an irregular geometric shape. The sintered particles of the calcium phosphate have a particle size smaller than 63 μm with a d50 value in the range from 5 to 20 μm. The interconnecting pore share in the overall porosity is limited to pore sizes less than 10 μm. The bone formation agent can be used in the form of a granulate or shaped body for bone regeneration. In the case of granulates, the maximum pore diameters are matched to the granulate diameter. The invention relates also to a method of producing the bone formation agent.
摘要翻译: 本发明涉及具有各向同性烧结结构的多孔磷酸钙的骨形成剂,以及磷酸钙颗粒之间在多个离散尺寸范围内的统计分布的孔。 骨形成剂具有至少两个,优选三个不连续的孔径分布。 其孔隙度具有不规则的几何形状。 磷酸钙的烧结颗粒具有小于63μm的颗粒尺寸,在5至20μm的范围内具有d <50%的值。 整体孔隙率的相互连通的孔隙分布限制在小于10um的孔径。 骨形成剂可以以用于骨再生的颗粒或成形体的形式使用。 在颗粒的情况下,最大孔径与颗粒直径相匹配。 本发明还涉及生成骨形成剂的方法。
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公开(公告)号:US08778374B2
公开(公告)日:2014-07-15
申请号:US10561800
申请日:2004-06-25
申请人: Fabian Peters , Frank Palm , Joachim Wittner , Ute Reif
发明人: Dieter Reif , Fabian Peters , Frank Palm , Joachim Wittner
IPC分类号: A61F2/00 , A61F13/00 , C04B35/447
CPC分类号: A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2002/2839 , A61F2002/30011 , A61F2002/30062 , A61F2002/30224 , A61F2002/3024 , A61F2002/30261 , A61F2002/30263 , A61F2002/30281 , A61F2002/30968 , A61F2210/0004 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2230/0086 , A61F2250/0023 , A61F2310/00293 , A61L24/0036 , A61L24/0068 , A61L27/12 , A61L27/56 , A61L2430/02 , B33Y80/00 , C04B35/447 , C04B35/6262 , C04B35/62695 , C04B38/0064 , C04B2111/00836 , C04B2235/3208 , C04B2235/3212 , C04B2235/5427 , C04B2235/5436 , C04B2235/5472 , C04B2235/77 , C04B2235/94 , C04B38/0051 , C04B38/0645
摘要: The invention relates to a bone formation agent of porous calcium phosphate having an isotropic sintered structure and, between the particles of the calcium phosphate, statistically distributed pores in a plurality of discrete size ranges. The bone formation agent has at least two, preferably three, discrete pore size distributions. Its porosity has an irregular geometric shape. The sintered particles of the calcium phosphate have a particle size smaller than 63 μm with a d50 value in the range from 5 to 20 μm. The interconnecting pore share in the overall porosity is limited to pore sizes less than 10 μm. The bone formation agent can be used in the form of a granulate or shaped body for bone regeneration. In the case of granulates, the maximum pore diameters are matched to the granulate diameter. The invention relates also to a method of producing the bone formation agent.
摘要翻译: 本发明涉及具有各向同性烧结结构的多孔磷酸钙的骨形成剂,以及磷酸钙颗粒之间在多个离散尺寸范围内的统计分布的孔。 骨形成剂具有至少两个,优选三个不连续的孔径分布。 其孔隙度具有不规则的几何形状。 磷酸钙的烧结颗粒的粒径小于63μm,d50值在5〜20μm的范围内。 整体孔隙率的相互连通的孔隙分布限制在小于10μm的孔径。 骨形成剂可以以用于骨再生的颗粒或成形体的形式使用。 在颗粒的情况下,最大孔径与颗粒直径相匹配。 本发明还涉及生成骨形成剂的方法。
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