公开(公告)号：US20050064491A1

公开(公告)日：2005-03-24

申请号：US10948493

申请日：2004-09-23

申请人： Steven Dworetzky ,  Chandra Ramanathan ,  Joanne Trojnacki ,  Christopher Boissard ,  Valentin Gribkoff

发明人： Steven Dworetzky ,  Chandra Ramanathan ,  Joanne Trojnacki ,  Christopher Boissard ,  Valentin Gribkoff

IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P11/06 ,  A61P17/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P35/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/02 ,  G01N33/15 ,  G01N37/00 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

摘要： An isolated polynucleotide encoding a novel potassium channel polypeptide, KCNQ5, that is expressed primarily in brain and skeletal muscle is described. The new polypeptide has been cloned and isolated from a human brain cDNA library and is a member the KCNQ family of potassium channels. The provided human KCNQ5 nucleic acid sequence and encoded polypeptide can be employed for diagnostic, screening and therapeutic uses. Moreover, the hKCNQ5 polypeptide can be used to assay for KCNQ5 potassium channel modulators, which can be utilized in the treatment of neurological, neurophysiological, neuropsychological and neuroaffective diseases, conditions and disorders, including, but not limited to, acute and chronic pain, migraine, acute stroke, dementia, vascular dementia, trauma, epilepsy, amyelotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson's Disease, learning and cognitive disorders, and neurophysiological disorders including anxiety disorders, depression, bipolar disorders, sleep disorders, addiction, and eating disorders.

摘要翻译： 描述了编码主要在脑和骨骼肌中表达的新型钾通道多肽KCNQ5的分离的多核苷酸。 新的多肽已经从人脑cDNA文库克隆和分离，并且是钾通道KCNQ家族的成员。 提供的人类KCNQ5核酸序列和编码的多肽可用于诊断，筛选和治疗用途。 此外，hKCNQ5多肽可用于测定KCNQ5钾通道调节剂，其可用于治疗神经，神经生理学，神经心理学和神经感染性疾病，病症和障碍，包括但不限于急性和慢性疼痛，偏头痛 ，急性中风，痴呆，血管性痴呆，创伤，癫痫，青光眼性侧索硬化（ALS），多发性硬化症（MS），帕金森病，学习和认知障碍以及神经生理学障碍，包括焦虑症，抑郁症，双相情感障碍，睡眠障碍，成瘾 和饮食失调。