公开(公告)号：US20050106632A1

公开(公告)日：2005-05-19

申请号：US10965608

申请日：2004-10-13

申请人： Steven Binder ,  Jodi Goodrich ,  Zara Safarian

发明人： Steven Binder ,  Jodi Goodrich ,  Zara Safarian

IPC分类号： G01N33/53 ,  G01N33/96

CPC分类号： G01N33/96 ,  G01N2333/9108 ,  Y10S435/973

摘要： Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. For serum samples, a negative result of an analysis for the presence of subunit a is a means of verifying that a sample is indeed serum, while a negative or positive result for subunit a serves to distinguish serum (negative) from plasma (positive). A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.

公开(公告)号：US20050106640A1

公开(公告)日：2005-05-19

申请号：US10966650

申请日：2004-10-14

申请人： Steven Binder ,  Jodi Goodrich ,  Zara Safarian

发明人： Steven Binder ,  Jodi Goodrich ,  Zara Safarian

IPC分类号： G01N33/53 ,  G01N33/96 ,  G01N33/567

CPC分类号： G01N33/96 ,  G01N2333/9108 ,  Y10S435/973

摘要： Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. For serum samples, a negative result of an analysis for the presence of subunit a is a means of verifying that a sample is indeed serum, while a negative or positive result for subunit a serves to distinguish serum (negative) from plasma (positive). A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.

摘要翻译： 使用血清样品对人因子XIII蛋白的两个亚基中任一个的存在和量的分析作为消除在血清和血浆测试中出现的重大误差源的手段。 对于血清样品，分析亚单位a的存在的阴性结果是验证样品确实为血清的方法，而亚单位a的阴性或阳性结果用于区分血清（阴性）和血浆（阳性）。 亚单位b的存在的阳性结果是验证样品是血清或血浆而不是任何其他生物流体的手段。 亚基b的定量分析是验证样品是否具有预期体积的手段，而不是由于不正确的取样而体积减小。 亚基b的定量分析也是验证血清或血浆样品稀释度的一种手段。