公开(公告)号：US20240041368A1

公开(公告)日：2024-02-08

申请号：US18449623

申请日：2023-08-14

申请人： Senseonics, Incorporated

发明人： Xiaoxiao Chen ,  Andrew Dehennis ,  Srinivasan Rajaraman

IPC分类号： A61B5/1495 ,  A61B5/00 ,  A61B5/145 ,  G01N33/66 ,  G01N33/96 ,  A61B5/15 ,  A61B5/1459

CPC分类号： A61B5/1495 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/742 ,  A61B5/14503 ,  G01N33/66 ,  G01N33/96 ,  A61B5/150022 ,  A61B5/1459 ,  A61B5/686 ,  A61B2560/0223 ,  A61B5/0004 ,  A61B5/15142

摘要： A method and transceiver for calibrating an analyte sensor using one or more reference measurements. In some embodiments, the method may include receiving a first reference analyte measurement (RM1) and determining whether the RM1 is unexpected. In some embodiments, the method may include, if the RM1 was determined to be unexpected, receiving a second reference analyte measurement (RM2). In some embodiments, the method may include determining whether one or more of the RM1 and the RM2 are acceptable as calibration points. In some embodiments, the method may include, if one or more of the RM1 and the RM2 are determined to be acceptable as calibration points, accepting one or more of the RM1 and the RM2 as calibration points. In some embodiments, the method may include calibrating the analyte sensor using at least one or more of the RM1 and the RM2 as calibration points.

公开(公告)号：US11826758B2

公开(公告)日：2023-11-28

申请号：US17821681

申请日：2022-08-23

申请人： Takeda Pharmaceutical Company Limited

发明人： Daniel J. Sexton ,  Ryan Faucette

IPC分类号： B01L3/00 ,  A61B5/15 ,  A61B5/154 ,  C07K16/40 ,  G01N33/564 ,  G01N33/573 ,  G01N33/96

CPC分类号： B01L3/5082 ,  A61B5/15003 ,  A61B5/154 ,  A61B5/150755 ,  C07K16/40 ,  G01N33/564 ,  G01N33/573 ,  G01N33/96 ,  B01L2200/16 ,  B01L2300/0832 ,  G01N2333/96433

摘要： Disclosed herein are evacuated blood collection tubes comprising protease inhibitor cocktails in liquid form and uses thereof for assessing features associated with the contact system in a subject, including the endogenous level of contact system activation, the endogenous level of a drug that targets a component of contact system during treatment, and/or the immunogenicity of such a drug.

公开(公告)号：US11728147B2

公开(公告)日：2023-08-15

申请号：US17502906

申请日：2021-10-15

申请人： Definitek, Inc.

发明人： Mehmet Pamukcu ,  Howard M. Kingston

IPC分类号： H01J49/00 ,  G01N33/96

CPC分类号： H01J49/0031 ,  G01N33/96

摘要： The present invention centers upon a novel “molecular amplification spike,” which is an admixture of two components, namely, an aliquot of a quantity of a molecule, composition, compound or element of interest (an “analyte”) in its natural isotopic state and an aliquot of an isotopically enriched form of the same molecule, composition, compound or element. The molecular amplification spike contains 20% natural-abundance isotope, balance enriched isotope. The molecular amplification spike may optionally contain more than 20% natural-abundance isotope, with concomitantly reduced balance of enriched isotope. Such an admixed spike, when added to a sample prior to mass spectrometric analysis of that sample, creates new and significantly improved percentage of errors and quantification or confirmation of the absence of the molecule, composition, compound or element of interest in the sample.

公开(公告)号：US20230204606A1

公开(公告)日：2023-06-29

申请号：US17995930

申请日：2021-04-22

申请人： Perosphere Technologies Inc.

发明人： Xuan Jiang ,  Lirong Chen ,  Yongchen Wang ,  Dardan Osmani ,  Stefan Zappe ,  Randy Byrd ,  Sasha H. Bakhru

IPC分类号： G01N33/96

CPC分类号： G01N33/96 ,  G01N2333/81 ,  G01N2496/25 ,  G01N2496/05

摘要： The preparation and use of systems to provide surrogate whole blood controls using coagulation modifiers to simulate human whole blood in coagulation assays are disclosed.

公开(公告)号：US20190195893A1

公开(公告)日：2019-06-27

申请号：US16299588

申请日：2019-03-12

申请人： BRAINBOX SOLUTIONS, INC.

发明人： RACHEL SOREK ,  KEREN JAKOBI ,  DONNA EDMONDS

IPC分类号： G01N33/68 ,  G01N33/543 ,  G01N33/96 ,  C07K14/47

CPC分类号： G01N33/6896 ,  C07K14/47 ,  G01N33/54366 ,  G01N33/96 ,  G01N2800/28 ,  G01N2800/52 ,  G01N2800/56

摘要： Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.

公开(公告)号：US20180273941A1

公开(公告)日：2018-09-27

申请号：US15521606

申请日：2015-10-24

申请人： University of Maryland, Baltimore

发明人： Li Mao ,  Yupin Mei

IPC分类号： C12N15/113 ,  G01N33/574 ,  A61K31/7088 ,  A61P35/00 ,  G01N33/96 ,  A61K48/00

CPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K48/0016 ,  A61K2300/00 ,  A61P35/00 ,  C12N2310/113 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/178 ,  G01N33/57423 ,  G01N33/96 ,  G01N2800/52

摘要： The present invention provides isolated nucleic acid molecules comprising short non-coding protein regulatory RNAs (sprRNA), variants, fragments and inhibitors thereof and compositions and methods of using the same.

公开(公告)号：US09952234B2

公开(公告)日：2018-04-24

申请号：US14966804

申请日：2015-12-11

申请人： Roche Diagnostics Operations, Inc.

发明人： Martin Horstmann ,  Fridl Lang

IPC分类号： G01N33/96 ,  G01N21/75 ,  G01N35/00 ,  G01J1/02 ,  G01N21/27 ,  G01N33/487

CPC分类号： G01N33/96 ,  G01J1/0295 ,  G01N21/274 ,  G01N21/75 ,  G01N33/487 ,  G01N35/00693 ,  G01N2201/12746 ,  G01N2496/00

摘要： A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.

公开(公告)号：US20180074012A1

公开(公告)日：2018-03-15

申请号：US15818341

申请日：2017-11-20

申请人： MEDTRONIC MINIMED, INC.

发明人： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC分类号： G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  G01N33/66 ,  G01N27/02 ,  A61M5/172 ,  A61M5/158 ,  A61B5/00 ,  A61B5/1495 ,  A61M5/142 ,  A61B5/053

CPC分类号： A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

摘要： A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20180017576A1

公开(公告)日：2018-01-18

申请号：US15544938

申请日：2016-01-21

申请人： Westfaelische Wilhelms-Universitaet Muenster

发明人： Johannes Roth ,  Thomas Vogl

IPC分类号： G01N33/68 ,  G01N33/96

CPC分类号： G01N33/6893 ,  G01N33/96 ,  G01N2333/4727 ,  G01N2800/52 ,  G01N2800/7095

摘要： The present invention relates to a compound for use in a method of diagnosing acute or chronic inflammatory diseases in a subject. In particular, the present invention provides a S100A8/S100A9 heterodimer standard comprising at least one mutation in low- or high-affinity calcium binding hand that can be used in a method of detecting biomarkers of inflammation in a sample. Accordingly, the S100A8/S100A9 heterodimer standard allows for standardizing quantitative immunoassays and quantifying S100A8/S100A9 heterodimers.

公开(公告)号：US20180011110A1

公开(公告)日：2018-01-11

申请号：US15543943

申请日：2016-01-26

申请人： The Governors of the University of Alberta

发明人： Abdolamir Landi ,  David Broadhurst ,  D. Lorne J. Tyrrell ,  Michael Houghton

IPC分类号： G01N33/68 ,  G01N33/563 ,  G01N33/74 ,  G01N33/96 ,  G01N33/58

CPC分类号： G01N33/6869 ,  A61K38/1866 ,  A61K38/19 ,  A61K38/2046 ,  A61K38/2086 ,  G01N33/563 ,  G01N33/582 ,  G01N33/6863 ,  G01N33/6896 ,  G01N33/74 ,  G01N33/96 ,  G01N2333/515 ,  G01N2333/521 ,  G01N2333/5418 ,  G01N2333/5446

摘要： The present disclosure provides methods and compositions that find use in facilitating a diagnosis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in a subject. The methods and compositions involve measurement of at least one of proteins: IL-16, IL-7, VEGF, CXCL9, CX3CL1, CCL24, CCL19, and CCL11 in a body fluid sample of a subject suspected of having CFS/ME. Levels of one or more of the aforementioned proteins can be used to facilitate a diagnosis of a CFS/ME and/or confirm a diagnosis of CFS/ME. The methods and compositions of the present disclosure also find use in screening subjects for clinical trials and facilitating treatment decisions for a subject.