公开(公告)号：US07713581B2

公开(公告)日：2010-05-11

申请号：US11598484

申请日：2006-11-09

申请人： Jürgen Heidlas ,  Zhengfeng Zhang ,  Kurt Stork ,  Johann Wiesmüller ,  Martin Ober ,  Johann Obersteiner

发明人： Jürgen Heidlas ,  Zhengfeng Zhang ,  Kurt Stork ,  Johann Wiesmüller ,  Martin Ober ,  Johann Obersteiner

IPC分类号： B05D7/00 ,  B05D3/04 ,  B01J13/02 ,  A61J3/07

CPC分类号： C08J9/122 ,  A01C1/06 ,  A01N25/00 ,  A23K40/00 ,  A23L5/00 ,  A23L5/30 ,  A23V2002/00 ,  C08J2201/032 ,  C08J2203/06 ,  C08J2203/08 ,  Y02P20/544 ,  A23V2300/44

摘要： The invention relates to a method for impregnating a support matrix with solid and/or liquid compounds using a compressed gas or a compressed mixture of gases at densities ranging from 0.15 to 1.3 kg/l and at least two unsymmetrical pressure changes (pulsations). The method is further characterized in that both a multitude of impregnating substances such as biologically active compounds, technical materials or metal-organic compounds, as well as support matrices of biological origin and organic or inorganic substances can be used that have large inner surfaces and/or inner surfaces that are difficult to access.

摘要翻译： 本发明涉及一种使用压缩气体或压缩的浓度为0.15-1.3kg / l和至少两个不对称压力变化（脉动）的气体的固体和/或液体化合物浸渍载体基质的方法。 该方法的特征还在于，可以使用诸如生物活性化合物，工业材料或金属有机化合物的许多浸渍物质，以及生物来源的支持基质和有机或无机物质，其具有大的内表面和/ 或难以进入的内表面。

公开(公告)号：US06288130B1

公开(公告)日：2001-09-11

申请号：US09381527

申请日：1999-09-20

申请人： Jürgen Heidlas ,  Karl-Heinz Zirzow ,  Johann Wiesmüller ,  Martin Ober ,  Franz Michlbauer ,  Jürgen Graefe

发明人： Jürgen Heidlas ,  Karl-Heinz Zirzow ,  Johann Wiesmüller ,  Martin Ober ,  Franz Michlbauer ,  Jürgen Graefe

IPC分类号： B01F1714

CPC分类号： A61K8/062 ,  A23J7/00 ,  A61K8/06 ,  A61K8/345 ,  A61K8/553 ,  A61K2800/52 ,  A61Q19/00 ,  C07F9/103

摘要： The invention relates to oil-free glycerophospholipid formulations which contain a homogeneous mixture of glycerophospholipids and an anhydrous, liquid polyol compound such as glycerol in a molar ratio of 1:0.1 to 1. These formulations are produced, eg, by extracting a starting material consisting of an oil-containing glycerophospholipid (mixture) and the polyol component with a compressed hydrocarbon (mixture) in a rectifying column. The oil-free formulation can be obtained from the melt at the bottom of the column in the form of free-flowing powder, which is ideally suited for stabilising oil-in-water emulsions.

摘要翻译： 本发明涉及无油甘油磷脂制剂，其含有摩尔比为1:0.1至1的甘油磷脂和无水液体多元醇化合物如甘油的均匀混合物。这些制剂例如通过提取包含 的含油甘油磷脂（混合物）和多元醇组分与精馏塔中的压缩烃（混合物）混合。 无油配方可以从柱底部的熔体以自由流动的粉末形式获得，其理想地适用于稳定水包油乳液。

公开(公告)号：US06599533B1

公开(公告)日：2003-07-29

申请号：US09381530

申请日：1999-09-21

申请人： Jürgen Heidlas ,  Karl-Heinz Zirzow ,  Johann Wiesmüller ,  Jürgen Graefe

发明人： Jürgen Heidlas ,  Karl-Heinz Zirzow ,  Johann Wiesmüller ,  Jürgen Graefe

IPC分类号： A61K914

CPC分类号： C07H11/04 ,  A01N25/04 ,  A23D9/013 ,  A23J7/00 ,  A23L29/10 ,  A61K8/553 ,  A61K8/675 ,  A61K8/676 ,  A61K8/678 ,  A61K9/145 ,  A61K47/24 ,  A61K2800/43 ,  A61K2800/52 ,  A61Q19/00 ,  B01F17/0064 ,  C05F11/00 ,  C07F9/103

摘要： This invention relates to homogeneous, anhydrous formulations which contain glycerophospholipids and polar or lipophilic substances (eg, physiologically active ingredients) in a molar ratio of 1:0.001 to 1:2, and maybe anhydrous formulation aids, eg, in the form of glycerol, in a molar ratio of 1:0.001 to 1:1, expressed in terms of the glycerophospholipids, the components forming such stable aggregates with one another as to render the formulations ideal for the preparation of dispersions, emulsions and/or suspensions in many fields of application, these including the food-processing sector, biotechnology, and the pharmaceuticals industry. The formulations are produced in an extraction column using compressed hydrocarbons, and are obtained from the column as a melt.

摘要翻译： 本发明涉及含有摩尔比为1:0.001-1:2的甘油磷脂和极性或亲脂性物质（例如生理活性成分）的均匀的无水制剂，以及可能是无水制剂助剂，例如以甘油的形式， 以相对于甘油磷脂表示的摩尔比为1:0.001-1:1，这些组分彼此形成这样的稳定​​的聚集体，以使制剂成为制备分散体，乳液和/或悬浮液在许多领域中的理想选择 应用，包括食品加工部门，生物技术和制药行业。 制剂在使用压缩烃的萃取塔中制备，并且作为熔体从塔中获得。

公开(公告)号：US06680284B1

公开(公告)日：2004-01-20

申请号：US10030035

申请日：2002-01-03

申请人： Jürgen Heidlas ,  Martin Ober ,  Johann Wiesmüller

发明人： Jürgen Heidlas ,  Martin Ober ,  Johann Wiesmüller

IPC分类号： A01N2512

CPC分类号： A61K9/14 ,  A61K9/1617 ,  Y10S514/959 ,  Y10S516/922 ,  Y10S516/928

摘要： For the preparation of pulverulent particle-reduced formulations with the aid of compressed gases, the solid compound to be formulated, a poorly soluble and usually bioactive active compound, is homogeneously ground together with 10-99% by weight (based on the formulation) of a carrier material which is essentially soluble in the compressed gas mixture, in the presence of compressed gas or mixtures thereof in a stirred autoclave having a mechanical grinding device at process temperatures between 10 and 200° C. and at process pressures between 5 and 500 bar, and in a second process stage the compressed gas mixture, usually dimethyl ether, pure propane and/or carbon dioxide, is expanded by lowering the pressure and separated off from the homogenate, which can also be present as a melt. Finally, the pulverulent particle-reduced formulation is recovered from the homogenate obtained, with which significant improvements in the solubility properties and in particular in the bioavailability of originally poorly soluble and nonsoluble compounds are to be achieved.

摘要翻译： 为了在压缩气体的帮助下制备粉末颗粒减少的制剂，将待配制的固体化合物，难溶性和通常为生物活性的活性化合物与10-99重量％（基于制剂）均匀地研磨 在压缩气体或其混合物的存在下，基本上可溶于压缩气体混合物的载体材料在具有机械研磨装置的搅拌高压釜中，处理温度为10-200℃，过程压力为5至500巴 ，并且在第二工艺阶段，压缩气体混合物，通常是二甲醚，纯丙烷和/或二氧化碳，通过降低压力而膨胀，并从匀浆中分离，其也可以熔体形式存在。 最后，从获得的匀浆中回收粉末颗粒减少的制剂，其中可以实现溶解性能，特别是原始难溶性和不溶性化合物的生物利用度的显着改善。