公开(公告)号：US07979119B2

公开(公告)日：2011-07-12

申请号：US11115752

申请日：2005-04-26

Applicant: Sridhar Kothandaraman ,  John D. H. King ,  Carla M. Woods

Inventor： Sridhar Kothandaraman ,  John D. H. King ,  Carla M. Woods

IPC: A61N1/00

CPC classification number: A61N1/36071 ,  G06F19/00 ,  G16H40/63

Abstract: Tissue stimulation systems, such as spinal cord stimulation systems, include a pulse generator to generate pulses at various amplitude, duration, and frequency through one or more electrodes. A visual depiction of both a pulse and an electrode configuration is thus provided herein. These depictions may be used in a stimulation display interface to readily convey stimulation parameter information to a user, wherein the interface is used in a stimulation session.

Abstract translation: 组织刺激系统，例如脊髓刺激系统，包括脉冲发生器，以通过一个或多个电极产生各种振幅，持续时间和频率的脉冲。 因此在此提供了脉冲和电极配置的视觉描绘。 这些描绘可以用在刺激显示界面中以便将刺激参数信息传达给用户，其中该界面用于刺激会话。

公开(公告)号：US08307820B2

公开(公告)日：2012-11-13

申请号：US12849761

申请日：2010-08-03

Applicant: John D. H. King ,  Thomas E. Oliver ,  Nicholas A. Kramer ,  Keeney D. Willis

Inventor： John D. H. King ,  Thomas E. Oliver ,  Nicholas A. Kramer ,  Keeney D. Willis

IPC: F24J2/14

CPC classification number: H02S40/44 ,  F24S10/72 ,  F24S10/73 ,  F24S20/25 ,  F24S20/70 ,  F24S20/80 ,  F24S23/745 ,  F24S23/77 ,  F24S23/81 ,  F24S23/82 ,  F24S30/425 ,  F24S2030/136 ,  H01L31/0547 ,  Y02E10/44 ,  Y02E10/45 ,  Y02E10/47 ,  Y02E10/52 ,  Y02E10/60

Abstract: A solar reflector assembly is provided for generating energy from solar radiation. The solar reflector assembly is configured to be deployed on a supporting body of liquid and to reflect solar radiation to a solar collector. A solar reflector assembly comprises an inflatable elongated tube having an upper portion formed at least partially of flexible material and a lower ballast portion formed at least partially of flexible material. A reflective sheet is coupled to a wall of the tube to reflect solar radiation. The elongated tube has an axis of rotation oriented generally parallel to a surface of a supporting body of liquid.

Abstract translation: 提供了用于从太阳辐射产生能量的太阳能反射器组件。 太阳能反射器组件被配置为展开在液体的支撑体上并将太阳辐射反射到太阳能收集器。 太阳能反射器组件包括可充气细长管，其具有至少部分地由柔性材料形成的上部部分和至少部分地由柔性材料形成的下部压载部分。 反射片耦合到管的壁以反射太阳辐射。 细长管具有大致平行于液体支撑体表面的旋转轴线。

公开(公告)号：US08036747B2

公开(公告)日：2011-10-11

申请号：US12506827

申请日：2009-07-21

Applicant: James R. Thacker ,  John D. H. King ,  Kerry Bradley

Inventor： James R. Thacker ,  John D. H. King ,  Kerry Bradley

IPC: A61N1/37

CPC classification number: A61N1/36071 ,  A61N1/0551

Abstract: A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.

Abstract translation: 用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。 切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。 估计的感知水平是基于以前的刺激结果。 然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

公开(公告)号：US20100095583A1

公开(公告)日：2010-04-22

申请号：US12253962

申请日：2008-10-18

Applicant: John D. H. King

Inventor： John D. H. King

IPC: A01G9/14 ,  B05D1/02 ,  B05D5/00

CPC classification number: C12M41/10 ,  C12M21/02 ,  C12M23/06 ,  C12M23/52 ,  C12M23/56

Abstract: A system and method are provided for protecting bio-reactor housing from solar radiation, by applying UV-protective material to an outer surface of a plastic wall of the bio-reactor housing to protect from solar radiation. The housing includes a wall formed of plastic that defines the outer surface. In this manner, the effective life of the housing is extended and the overall cost of generation of photosynthetic biomass is decreased, improving system performance and cost-effectiveness.

Abstract translation: 提供了一种系统和方法，用于通过将UV保护材料施加到生物反应器壳体的塑料壁的外表面以防止太阳辐射来保护生物反应器壳体免遭太阳辐射。 壳体包括限定外表面的由塑料形成的壁。 以这种方式，延长了住房的有效寿命，降低了光合生物量的总体成本，提高了系统性能和成本效益。

公开(公告)号：US08626312B2

公开(公告)日：2014-01-07

申请号：US13069143

申请日：2011-03-22

Applicant: John D. H. King ,  James R. Thacker

Inventor： John D. H. King ,  James R. Thacker

IPC: A61N1/37

CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

Abstract translation: 神经刺激系统自动校正或调整刺激量值（刺激能量），以保持舒适有效的刺激治疗。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US08389064B2

公开(公告)日：2013-03-05

申请号：US12253962

申请日：2008-10-18

Applicant: John D. H. King

Inventor： John D. H. King

IPC: B05D1/02 ,  B05D5/00 ,  B05D7/00 ,  B28B19/00 ,  B29B15/10 ,  C23C18/00 ,  C23C20/00 ,  C23C28/00

CPC classification number: C12M41/10 ,  C12M21/02 ,  C12M23/06 ,  C12M23/52 ,  C12M23/56

Abstract: A system and method are provided for protecting bio-reactor housing from solar radiation, by applying UV-protective material to an outer surface of a plastic wall of the bio-reactor housing to protect from solar radiation. The housing includes a wall formed of plastic that defines the outer surface. In this manner, the effective life of the housing is extended and the overall cost of generation of photosynthetic biomass is decreased, improving system performance and cost-effectiveness.

Abstract translation: 提供了一种系统和方法，用于通过将UV保护材料施加到生物反应器壳体的塑料壁的外表面以防止太阳辐射来保护生物反应器壳体免遭太阳辐射。 壳体包括限定外表面的由塑料形成的壁。 以这种方式，延长了住房的有效寿命，降低了光合生物量的总体成本，提高了系统性能和成本效益。

公开(公告)号：US07742823B2

公开(公告)日：2010-06-22

申请号：US11746748

申请日：2007-05-10

Applicant: John D. H. King ,  James R. Thacker

Inventor： John D. H. King ,  James R. Thacker

IPC: A61N1/08

CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

Abstract translation: 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US09205263B2

公开(公告)日：2015-12-08

申请号：US12783187

申请日：2010-05-19

Applicant: John D. H. King ,  James R. Thacker

Inventor： John D. H. King ,  James R. Thacker

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/08

CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

Abstract translation: 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US20110113806A1

公开(公告)日：2011-05-19

申请号：US12950931

申请日：2010-11-19

Applicant: John D. H. King ,  Nicholas A. Kramer ,  Thomas E. Oliver

Inventor： John D. H. King ,  Nicholas A. Kramer ,  Thomas E. Oliver

IPC: F25B27/00 ,  F24F7/00

CPC classification number: F24S23/77 ,  F24S10/72 ,  F24S10/73 ,  F24S20/25 ,  F24S20/70 ,  F24S20/80 ,  F24S23/81 ,  F24S23/82 ,  F24S30/425 ,  Y02E10/44 ,  Y02E10/47

Abstract: A dry cooling assembly is provided comprising a supporting body of liquid having a temperature higher than ambient temperature, and an inflatable elongated tube at least partially submerged in the supporting body of liquid. The inflatable elongated tube has an upper portion formed at least partially of flexible material and a lower ballast portion formed at least partially of flexible material. The lower ballast portion defines a reservoir containing liquid facilitating ballast. The liquid facilitating ballast is warmed by heat from the supporting body of liquid such that the temperature of the support body of liquid is reduced.

Abstract translation: 提供了一种干燥冷却组件，其包括具有高于环境温度的温度的液体的支撑体，以及至少部分地浸没在液体支撑体中的可充气细长管。 可充气细长管具有至少部分由柔性材料形成的上部部分和至少部分由柔性材料形成的下部压载部分。 下部压载部分限定了容纳用于镇流器的液体的储存器。 液体促进镇流器通过来自液体支撑体的热量加热，使得液体的支撑体的温度降低。

公开(公告)号：US20100210003A1

公开(公告)日：2010-08-19

申请号：US12705902

申请日：2010-02-15

Applicant: John D. H. King ,  Keeney D. Willis

Inventor： John D. H. King ,  Keeney D. Willis

IPC: C12N1/12 ,  C12M1/12

CPC classification number: C12N1/02 ,  C12M21/02 ,  C12M23/06 ,  C12M23/18 ,  C12M27/20 ,  C12M29/02 ,  C12M33/10 ,  C12N1/12 ,  Y02W10/37

Abstract: A system and related method for concentrating biological culture and circulating biological culture and process fluid is provided. The system includes a continuous flow separator that removes excess fluid from the culture medium, resulting in a “concentrated medium” of fluid. The concentrated medium is then passed along for further processing to capture the biomass. The overflow, i.e., the extracted fluid, from the continuous flow separator is reintroduced into the container in a manner to circulate the culture medium. Thus, energy from the concentration step is utilized to circulate the culture medium, alleviating the need for significant additional structure for circulating the culture medium. In this manner, the system grows and captures biological material in an energy and capital efficient manner.

Abstract translation: 提供了一种用于浓缩生物培养和循环生物培养和过程流体的系统和相关方法。 该系统包括连续流分离器，其从培养基中除去多余的流体，导致流体的“浓缩介质”。 然后将浓缩的介质通过以进行进一步处理以捕获生物质。 来自连续流分离器的溢出物，即提取的流体以使循环培养基的方式被重新引入到容器中。 因此，利用来自浓缩步骤的能量来循环培养基，减轻了对用于循环培养基的显着额外结构的需要。 以这种方式，系统以能量和资本有效的方式增长和捕获生物材料。