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    Charge recovery bi-phasic control for tissue stimulation
    2.
    发明授权
    Charge recovery bi-phasic control for tissue stimulation 有权
    电荷恢复双相控制组织刺激

    公开(公告)号：US09415223B2

    公开(公告)日：2016-08-16

    申请号：US12938202

    申请日：2010-11-02

    申请人： Rafael Carbunaru ,  Kerry Bradley

    发明人： Rafael Carbunaru ,  Kerry Bradley

    IPC分类号： A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/36178 ,  A61N1/0551 ,  A61N1/36125 ,  A61N1/36128 ,  A61N1/36185

    摘要： A method and external control device for providing therapy to a patient using first and second electrodes implanted within the patient is provided. A train of electrical multi-phasic pulses is generated. A first electrical current is sourced from the second electrode and at least a portion of the first electrical current is sunk to the first electrode during a stimulation phase of each multi-phasic pulse, thereby therapeutically stimulating a first tissue region adjacent the first electrode. A second electrical current is sourced from the first electrode and at least a portion of the second electrical current is sunk to the second electrode during a charge recovery phase of each multi-phasic pulse, thereby recovering at least a portion of the charge that had been injected into the patient during the stimulation phase of each multi-phasic pulse, and therapeutically stimulating a second tissue region adjacent the second electrode.

    摘要翻译： 提供了一种方法和外部控制装置，其用于使用植入患者体内的第一和第二电极向患者提供治疗。 产生一系列电多相脉冲。 第一电流来自第二电极，并且在每个多相脉冲的刺激阶段期间，第一电流的至少一部分被吸入第一电极，从而治疗性地刺激与第一电极相邻的第一组织区域。 在每个多相脉冲的充电恢复阶段期间，第二电流来自第一电极，并且第二电流的至少一部分被吸入第二电极，由此回收至少一部分电荷 在每个多阶段脉冲的刺激阶段期间注射到患者体内，以及治疗性刺激与第二电极相邻的第二组织区域。

    Neurostimulation system with on-effector programmer control
    4.
    发明授权
    Neurostimulation system with on-effector programmer control 有权
    具有效应器程序员控制的神经刺激系统

    公开(公告)号：US08977360B2

    公开(公告)日：2015-03-10

    申请号：US13469990

    申请日：2012-05-11

    申请人： Chester Kim ,  Mun Pook Lui ,  Kerry Bradley

    发明人： Chester Kim ,  Mun Pook Lui ,  Kerry Bradley

    IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/372

    CPC分类号： A61N1/36071 ,  A61N1/36157 ,  A61N1/36185 ,  A61N1/37247

    摘要： An external control device for use with a programmable implantable medical device coupled to an operative element. The external control device comprises a user interface comprising a control element and a display screen configured for displaying a graphical representation of the operative element. The external control device further comprises control circuitry configured for prompting the display screen to superimpose a graphical programmer control over the graphical representation of the operative element when the control element is actuated, and modifying an operational parameter for the operative element in response to actuation of the graphical programmer control. The external control device further comprises output circuitry configured for transmitting the modified operational parameter to the programmable implantable medical device.

    摘要翻译： 一种用于与可操作元件耦合的可编程可植入医疗装置的外部控制装置。 外部控制装置包括用户界面，其包括控制元件和被配置为显示操作元件的图形表示的显示屏幕。 所述外部控制装置还包括控制电路，所述控制电路经配置以在所述控制元件被致动时提示所述显示屏幕将图形编程器控制叠加在所述操作元件的图形表示上，以及响应于所述操作元件的致动而修改所述操作元件的操作参数 图形编程器控制。 外部控制装置还包括被配置为将修改的操作参数传送到可编程可植入医疗装置的输出电路。

    System and method for modulating action potential propagation during spinal cord stimulation
    5.
    发明授权
    System and method for modulating action potential propagation during spinal cord stimulation 有权
    用于调节脊髓刺激期间动作电位传播的系统和方法

    公开(公告)号：US08504160B2

    公开(公告)日：2013-08-06

    申请号：US12618563

    申请日：2009-11-13

    申请人： Dongchul Lee ,  Kerry Bradley

    发明人： Dongchul Lee ,  Kerry Bradley

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36071 ,  A61N1/36 ,  A61N1/3605

    摘要： A method and neurostimulator for providing therapy to a patient is provided. In one technique, an electrical pulsed waveform is conveyed between a caudal electrode and spinal cord tissue, thereby evoking action potentials that are orthodromically propagated along dorsal column fibers and evoking action potentials that are antidromically propagated along the DC fibers. Electrical energy is conveyed between a rostral electrode and the spinal cord tissue, thereby modulating times that the action potentials orthodromically propagated along the DC fibers arrive at the brain. In another technique, an electrical pulsed waveform is conveyed through a first electrode, thereby evoking action potentials that are propagated along a neural axon, and electrical energy is conveyed through the second electrode. The electrical energy has a frequency that is greater than a pulse rate of the electrical pulsed waveform, such that the action potentials propagated along the neural axon are blocked by the electrical energy.

    摘要翻译： 提供了一种用于向患者提供治疗的方法和神经刺激器。 在一种技术中，电脉冲波形在尾部电极和脊髓组织之间传送，从而引起沿背侧纤维正交传播的动作电位并引起沿着DC纤维反向传播的动作电位。 电能在脊髓电极和脊髓组织之间传送，从而调节沿着DC纤维正交传播的动作电位到达脑部的时间。 在另一种技术中，电脉冲波形被传送通过第一电极，从而引起沿着神经轴突传播的动作电位，并且电能被传送通过第二电极。 电能的频率大于电脉冲波形的脉冲频率，使得沿着神经轴突传播的动作电位被电能阻挡。

    AUTONOMIC MODULATION USING PERIPHERAL NERVE FIELD STIMULATION
    6.
    发明申请
    AUTONOMIC MODULATION USING PERIPHERAL NERVE FIELD STIMULATION 有权
    使用外周神经网络自动化调制

    公开(公告)号：US20130138167A1

    公开(公告)日：2013-05-30

    申请号：US13686336

    申请日：2012-11-27

    申请人： Kerry Bradley ,  Rafael Carbunaru ,  Jason J. Hamann

    发明人： Kerry Bradley ,  Rafael Carbunaru ,  Jason J. Hamann

    IPC分类号： A61N1/36 ,  A61N1/39

    CPC分类号： A61N1/36114 ,  A61N1/3605 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/36146 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/37235 ,  A61N1/37282 ,  A61N1/37288 ,  A61N1/3962

    摘要： Some embodiments provide a system, comprising a peripheral nerve field modulation (PNFM) therapy delivery system, PNFM electrodes configured to be implanted subcutaneously, and a controller. The PNFM electrodes are electrically connected to the PNFM therapy system. The PNFM therapy delivery system and the PNFM electrodes are configured to deliver current and/or control the field potentials at one or more peripheral nerve fields. The controller is configured to control the PNFM therapy delivery system to deliver a PNFM therapy to the one or more peripheral nerve fields. The controller includes a scheduler configured to control timing of the PNFM therapy.

    摘要翻译： 一些实施例提供一种包括周边神经域调制（PNFM）治疗递送系统，以及被配置为皮下植入的PNFM电极和控制器的系统。 PNFM电极电连接到PNFM治疗系统。 PNFM治疗递送系统和PNFM电极被配置为在一个或多个周围神经区传递电流和/或控制场电位。 控制器被配置为控制PNFM治疗递送系统将PNFM治疗递送到一个或多个周围神经区域。 控制器包括被配置为控制PNFM治疗的定时的调度器。

    SYSTEM AND METHOD FOR USING IMPEDANCE TO DETERMINE PROXIMITY AND ORIENTATION OF SEGMENTED ELECTRODES
    7.
    发明申请
    SYSTEM AND METHOD FOR USING IMPEDANCE TO DETERMINE PROXIMITY AND ORIENTATION OF SEGMENTED ELECTRODES 有权
    使用阻抗确定分离电极的近似性和方位的系统和方法

    公开(公告)号：US20130006324A1

    公开(公告)日：2013-01-03

    申请号：US13533532

    申请日：2012-06-26

    申请人： Kerry Bradley

    发明人： Kerry Bradley

    IPC分类号： A61N1/05 ,  A61N1/36

    CPC分类号： A61N1/08 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/068 ,  A61N1/0551 ,  A61N1/36125 ,  A61N1/36182 ,  A61N1/37217 ,  A61N1/37241 ,  A61N1/3787

    摘要： A method for implanting a neurostimulation lead within a patient includes measuring impedances of electrodes on the lead in order to correctly position the lead relative to a target tissue region. The electrodes are circumferentially segmented electrodes that are spaced from each other about the longitudinal axis of the lead. When the difference between the impedances of the electrodes exceeds a threshold value, the lead is in the correct position. In accordance with another embodiment, impedance measurements are used to select which one of the electrodes is closest to the target tissue region. By determining which electrode has the highest impedance and which electrode has the lowest impedance, the type of tissue adjacent to each electrode can be determined based on the conductivity properties of the tissue. The target tissue region may be a spinal cord, a posterior longitudinal ligament, white matter, or gray matter.

    摘要翻译： 用于在患者体内植入神经刺激引线的方法包括测量引线上的电极的阻抗，以便使引线相对于目标组织区域正确定位。 电极是周向分段的电极，其围绕导线的纵向轴线彼此间隔开。 当电极的阻抗差超过阈值时，引线处于正确的位置。 根据另一个实施例，使用阻抗测量来选择哪个电极最靠近目标组织区域。 通过确定哪个电极具有最高阻抗并且哪个电极具有最低的阻抗，可以基于组织的电导率特性来确定与每个电极相邻的组织的类型。 目标组织区域可以是脊髓，后纵韧带，白质或灰质。

    METHOD FOR IMPROVING FAR-FIELD ACTIVATION IN PERIPHERAL FIELD NERVE STIMULATION
    8.
    发明申请
    METHOD FOR IMPROVING FAR-FIELD ACTIVATION IN PERIPHERAL FIELD NERVE STIMULATION 失效
    用于改善外周场神经刺激中的场激活的方法

    公开(公告)号：US20120330218A1

    公开(公告)日：2012-12-27

    申请号：US13529928

    申请日：2012-06-21

    申请人： Kerry Bradley

    发明人： Kerry Bradley

    IPC分类号： A61N1/05 ,  A61M37/00

    CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/3605

    摘要： A method of providing therapy to a patient having a disorder using an electrode located adjacent a peripheral target neural region. The method comprises conveying electrical stimulation energy from the electrode that stimulates a first set of nerve endings in the peripheral target neural region. The method further comprises increasing an activation threshold of a second set of nerve endings in the peripheral target neural region, thereby rendering the second set of nerve endings less excitable to the electrical stimulation energy. The first set of nerve endings are relatively far from the electrode and the second set of nerve endings are relatively near the electrode.

    摘要翻译： 使用位于周边靶神经区域附近的电极向病人提供治疗的方法。 该方法包括从刺激第一组神经末梢的周围靶神经区域的电极输送电刺激能量。 所述方法还包括增加周围目标神经区域中第二组神经末梢的激活阈值，从而使第二组神经末梢对电刺激能量更不可兴奋。 第一组神经末梢距离电极相对较远，第二组神经末梢相对靠近电极。

    SYSTEM AND METHOD FOR PROVIDING FLUID REAL-TIME VISUALIZATION OF REGION OF TISSUE ACTIVATION
    10.
    发明申请
    SYSTEM AND METHOD FOR PROVIDING FLUID REAL-TIME VISUALIZATION OF REGION OF TISSUE ACTIVATION 有权
    用于提供组织活化区域的流体实时可视化的系统和方法

    公开(公告)号：US20120109257A1

    公开(公告)日：2012-05-03

    申请号：US13244415

    申请日：2011-09-24

    申请人： Peter J. Yoo ,  Michael A. Moffitt ,  Kerry Bradley

    发明人： Peter J. Yoo ,  Michael A. Moffitt ,  Kerry Bradley

    IPC分类号： A61N1/372

    CPC分类号： A61N1/37247 ,  A61N1/36135 ,  A61N1/36185

    摘要： A system for a tissue stimulator coupled to an array of electrodes. The system comprises a user-controlled input device configured for generating control signals, and at least one processor configured for generating a plurality of stimulation parameter sets in response to the control signals that, when applied to the electrodes, will shift electrical current between electrodes to modify a region of tissue activation. The processor(s) is further configured for computing an estimate of the region of tissue activation, and for generating display signals capable of prompting a monitor to display an animated graphical representation of the computed estimate of the region of tissue activation.

    摘要翻译： 一种耦合到电极阵列的组织刺激器的系统。 该系统包括被配置为产生控制信号的用户控制的输入装置，以及至少一个处理器，被配置为响应于控制信号产生多个刺激参数集合，当被施加到电极时将使电极之间的电流移位到 修改组织激活的区域。 处理器还被配置用于计算组织激活区域的估计，并且用于产生能够促使监视器显示所计算的组织激活区域的估计的动画图形表示的显示信号。