公开(公告)号：US5611661A

公开(公告)日：1997-03-18

申请号：US530175

申请日：1995-11-30

Applicant: John Jenkinson

Inventor： John Jenkinson

IPC: F01D25/18

CPC classification number: F01D25/183

Abstract: An aircraft gas turbine has a barrier air flow produced by the fan or a low-pressure compressor which passes continuously through the compressor bearing chamber, while the turbine bearing chamber is supplied with barrier air by the high-pressure compressor. The barrier air flow drawn from the turbine bearing chamber passes into an ejector which is also connected to the compressor bearing chamber so that, when the pressure is insufficient, the barrier air flow is drawn-off by the ejector.

Abstract translation: PCT No.PCT / EP94 / 00854 Sec。 371日期：1995年11月30日 102（e）1995年11月30日日期PCT 1994年3月18日PCT公布。 第WO94 / 23184号公报 日期1994年10月13日飞机燃气轮机具有由风扇或低压压缩机产生的阻挡气流，该低压压缩机连续通过压缩机轴承室，而涡轮轴承室由高压压缩机供给障碍空气。 从涡轮机轴承室抽出的阻挡空气流进入喷射器，喷射器也连接到压缩机轴承室，使得当压力不足时，阻挡气流被喷射器排出。

公开(公告)号：US4178129A

公开(公告)日：1979-12-11

申请号：US874741

申请日：1978-02-03

Applicant: John Jenkinson

Inventor： John Jenkinson

IPC: F01D5/18 ,  F01D5/08

CPC classification number: F01D5/081

Abstract: In a blade cooling system for a turbine of a gas turbine engine each blade root is provided with individual pitot receivers which collect a portion of a cooling fluid flow supplied from an annular array of pre-swirl nozzles, which have a circumferentially continuous outlet flow area, and direct said flow into a portion only of the interior of the blade, preferably adjacent the leading edge.

Abstract translation: 在用于燃气涡轮发动机的涡轮机的叶片冷却系统中，每个叶片根部设置有单独的皮托接收器，其收集从环形阵列的预旋喷嘴提供的冷却流体流的一部分，其具有周向连续的出口流动面积 并且将所述流直接引导到叶片的内部的一部分中，优选地邻近前缘。

公开(公告)号：US3982850A

公开(公告)日：1976-09-28

申请号：US587168

申请日：1975-06-16

Applicant: John Jenkinson

Inventor： John Jenkinson

IPC: F01B31/06 ,  F01D11/02 ,  F01D11/18 ,  F01D25/08 ,  F02C7/00 ,  F02C7/24 ,  F01D5/00

CPC classification number: F01D11/025 ,  F01D11/18 ,  Y02T50/671

Abstract: Thermal matching of compounds in a gas turbine engine is achieved by providing the component with the highest rate of thermal expansion with an insulating sheet which is dimpled to contact the surface of the component at discrete spots leaving air spaces in between. The sheet is attached to the component by spot welding at a pre-determined number of areas to provide the necessary heat conducting paths between the insulation and the component to enable the expansion of the component to be matched with that of another component. Seal clearances can be reduced by matching the expansions of seal carrying components in this way.

Abstract translation: 燃气涡轮发动机中的化合物的热匹配是通过提供具有最高热膨胀率的部件来实现的，该绝缘片被凹陷以在离散的位置处接触组件的表面，从而在其间留有空气间隙。 该片材通过在预定数量的区域上的点焊附接到部件上，以在绝缘体和部件之间提供必要的导热路径，以使部件膨胀以与另一部件匹配。 通过以这种方式匹配密封件承载部件的膨胀，可以减少密封间隙。

公开(公告)号：US20050136040A1

公开(公告)日：2005-06-23

申请号：US10824584

申请日：2004-04-08

Applicant: Stephen Hart ,  Simak Ali ,  Boris PuFong ,  Andrew Porter ,  Laki Buluwela ,  Satu Vainikka ,  John Jenkinson ,  Patrick Kanda

Inventor： Stephen Hart ,  Simak Ali ,  Boris PuFong ,  Andrew Porter ,  Laki Buluwela ,  Satu Vainikka ,  John Jenkinson ,  Patrick Kanda

IPC: A61K9/127 ,  A61K48/00 ,  C07H21/04 ,  C12N5/04 ,  C12N15/113 ,  C12N15/63 ,  C12N5/08

CPC classification number: C12N15/113 ,  C12N15/1138 ,  C12N15/63 ,  C12N2310/15 ,  C12N2310/335 ,  C12N2310/336 ,  C12N2310/3513

Abstract: A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.

Abstract translation: 一种抑制细胞中所选择的基因表达的方法，包括向细胞中引入分子，所述分子包含（1）核酸结合部分，所述核酸结合部分结合位点或与所选基因相关联，所述基因存在于基因组中， （2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。 提供了用于本发明方法的分子。 阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。

公开(公告)号：US20060247192A1

公开(公告)日：2006-11-02

申请号：US10536664

申请日：2003-12-05

Applicant: John Jenkinson ,  Patrick Kanda ,  Satu Vainikka

Inventor： John Jenkinson ,  Patrick Kanda ,  Satu Vainikka

IPC: A61K48/00

CPC classification number: C12N15/1135 ,  A61K38/45 ,  C12N2310/11 ,  C12N2310/15 ,  C12N2310/3513 ,  C12Q1/6811 ,  A61K2300/00

Abstract: A method for suppressing the expression of a selected apoptosis-related gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site at or associated with the selected gene which site is present in a genome and (2) a modifying portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor or modifying portion may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase. The nucleic acid binding portion may be a triplex forming oligonucleotide (TFO). The apoptosis-related gene may be Bcl-2. The methods and molecules

Abstract translation: 一种抑制细胞中选择的细胞凋亡相关基因表达的方法，包括向细胞中引入分子，该分子包含（1）核酸结合部分，所述核酸结合部分结合选定基因所在位点或与所选基因相关，该位点存在 在基因组中和（2）修饰部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。 提供了用于本发明方法的分子。 阻遏物或修饰部分可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。 核酸结合部分可以是形成三链体的寡核苷酸（TFO）。 凋亡相关基因可能是Bcl-2。 方法和分子