公开(公告)号：US06948522B2

公开(公告)日：2005-09-27

申请号：US10457283

申请日：2003-06-06

申请人： Jerry W. Newbrough ,  James S. Slepicka ,  Arnold C. Bilstad ,  John Mark DeFoggi ,  Marianne M. Boschelli ,  Alice M. Jandrisits ,  Bihong Wu

发明人： Jerry W. Newbrough ,  James S. Slepicka ,  Arnold C. Bilstad ,  John Mark DeFoggi ,  Marianne M. Boschelli ,  Alice M. Jandrisits ,  Bihong Wu

IPC分类号： A61J1/00 ,  A61J1/20 ,  B65B1/04 ,  A61B19/00 ,  A61M5/00 ,  F61L37/28

CPC分类号： A61J1/2089 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2058 ,  A61J1/2075 ,  A61J1/2082 ,  Y10T137/8122 ,  Y10T137/8342 ,  Y10T137/8622

摘要： A reconstitution device is disclosed and includes a first container receiver having a first component cannula disposed therein, the first component cannula having a withdrawal port and a first transfer port formed thereon, a second container receiver having a second component cannula disposed thereon, the second component cannula having a vent port and a second transfer port formed thereon, a device body coupling the first container receiver to the second container receiver and having a transfer lumen formed therein, the transfer lumen in fluid communication with the first and second transfer ports, a selectively sealing interface secured to the device body and in fluid communication with the withdrawal port, and a venting member in communication with the vent port through a vent lumen.

摘要翻译： 公开了重构装置，并且包括第一容器接收器，其具有设置在其中的第一部件插管，第一部件插管具有取出口和形成在其上的第一传送端口，第二容器接收器具有设置在其上的第二部件插管，第二部件 插管，其具有形成在其上的通气口和第二传送端口，将第一容器接收器连接到第二容器接收器并且具有形成在其中的传送腔的设备本体，与第一和第二传送端口流体连通的传送腔， 密封界面固定到装置主体并与抽出口流体连通;以及排气构件，其通过通气腔与通气口连通。

公开(公告)号：US06358236B1

公开(公告)日：2002-03-19

申请号：US09129898

申请日：1998-08-06

申请人： John Mark DeFoggi ,  Arnold Bilstad ,  Ingrid McPhilliamy

发明人： John Mark DeFoggi ,  Arnold Bilstad ,  Ingrid McPhilliamy

IPC分类号： A61B1900

CPC分类号： A61J1/2096 ,  A61J1/201 ,  A61J1/2072 ,  A61J1/2086 ,  Y10S604/905

摘要： A device is provided for reconstituting a lyophilized or powdered medicament such as blood factor VIII which must be reconstituted just prior to use, such as by introduction of a sterile fluid from a syringe, which comprises a housing having an upper section capable of receiving a syringe and a lower section capable of receiving a vial containing the medicament in co-axial alignment with the syringe, a middle section connecting the upper and lower sections which has a central aperture which forms a passageway for fluid transfer between the syringe and the vial, and a hollow vented spike which extends downwardly from the central aperture for a length sufficient to ensure that the lower end of the spike will pierce the seal and enter the interior of a vial housed in the lower section of the device. The invention is advantageous because the vented opening in the spike will allow for an equalization of the pressure after the piercing of the vial by the spike which will facilitate the use of the device. In addition, the device also features an ergonomic design which maximizes the safety and efficiency of the reconstitution of important medicaments such as blood factors, and allows for easily manipulation of the device by patients such as those with Factor VIII deficiency who may suffer from related physical ailments which limit their dexterity.

摘要翻译： 提供了用于重建冻干或粉末状药物如血液因子VIII的装置，其必须在使用前必须重构，例如通过从注射器引入无菌流体，其包括具有能够接收注射器的上部的壳体 以及下部，其能够接收包含与注射器同轴对准的药物的小瓶;连接上部和下部的中间部分，其具有形成用于注射器和小瓶之间的流体传送的通道的中心孔，以及 一个从中心孔向下延伸一段足够长度的中空通风尖钉，以确保尖峰的下端将刺穿密封并进入容纳在装置下部的小瓶的内部。 本发明是有利的，因为尖钉中的排气孔将允许通过尖端刺穿小瓶之后的压力平衡，这将有利于装置的使用。 此外，该装置还具有符合人体工程学的设计，使重要药物（如血液因子）重建的安全性和效率最大化，并允许患者轻松操作患者，例如患有因子VIII缺乏症的患者，可能患有相关的身体 疾病限制了他们的灵巧。