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    PULMONARY DELIVERY OF SPHERICAL INSULIN MICROPARTICLES
    3.
    发明申请
    PULMONARY DELIVERY OF SPHERICAL INSULIN MICROPARTICLES 审中-公开
    脉冲胰岛素微生物的脉冲递送

    公开(公告)号：US20080026068A1

    公开(公告)日：2008-01-31

    申请号：US11736372

    申请日：2007-04-17

    申请人： Larry Brown ,  John McGeehan ,  Qin Yuanxi ,  Julia Rashba-Step ,  Terrence Scott

    发明人： Larry Brown ,  John McGeehan ,  Qin Yuanxi ,  Julia Rashba-Step ,  Terrence Scott

    IPC分类号： A61K9/14 ,  A61K38/28 ,  A61P11/00

    CPC分类号： A61K9/0075 ,  A61K38/28

    摘要： Compositions of spherical insulin particles having improved pulmonary application potentials and methods of forming and using these compositions are disclosed in the present application. In one clinical trial with 30 healthy male human subjects, no coughing was observed upon a single pulmonary administration of the spherical insulin particles at an insulin dose of 6.5 mg, nor during the 10-hour post dosing period.

    摘要翻译： 在本申请中公开了具有改善的肺部施用电位的球形胰岛素颗粒的组合物以及形成和使用这些组合物的方法。 在30名健康雄性人类受试者的一项临床试验中，在胰岛素剂量为6.5mg的单次肺部施用球素胰岛素颗粒时，也不在给药后10小时期间观察不到咳嗽。

    Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation
    5.
    发明申请
    Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation 有权
    通过控制相分离制备的小球形颗粒的制备方法，用途和组成

    公开(公告)号：US20050142206A1

    公开(公告)日：2005-06-30

    申请号：US10894430

    申请日：2004-07-19

    申请人： Larry Brown ,  John McGeehan ,  Julia Rashba-Step ,  Terrence Scott

    发明人： Larry Brown ,  John McGeehan ,  Julia Rashba-Step ,  Terrence Scott

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K38/27 ,  A61K38/28 ,  A61K38/54 ,  B01J13/06

    CPC分类号： B01J13/06 ,  A61K9/5026 ,  A61K9/5031 ,  A61K38/28

    摘要： The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 μm to about 200 μm.

    摘要翻译： 本发明涉及通过在单一液相中提供溶液来制备活性剂的小球形颗粒的方法。 单液相包含活性剂，相分离增强剂和第一溶剂。 在溶液中以受控的速率诱导相变，引起活性剂的液固相分离并形成固相和液相。 固相包含活性剂的固体小球形颗粒。 液相包含相分离增效剂和溶剂。 小球形颗粒基本上是球形的并且具有约0.01μm至约200μm的尺寸。

    Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
    6.
    发明申请
    Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof 审中-公开
    低分子量有机分子的小球形颗粒及其制备方法和用途

    公开(公告)号：US20050048127A1

    公开(公告)日：2005-03-03

    申请号：US10896326

    申请日：2004-07-21

    申请人： Larry Brown ,  Debra Lafreniere ,  John McGeehan

    发明人： Larry Brown ,  Debra Lafreniere ,  John McGeehan

    IPC分类号： A61K20060101 ,  A61K9/00 ,  A61K9/14

    CPC分类号： A61K9/14 ,  A61K9/0019 ,  A61K9/0075

    摘要： The invention provides homogeneous small spherical particles of low molecular weight organic molecules, said small spherical particles having a uniform shape, a narrow size distribution and average diameter of 0.01-200 μm. The invention further provides methods of preparation and methods of use of the small spherical particles. These small spherical particles are suitable for applications that require delivery of micron-size or nanosized particles with uniform size and good aerodynamic or flow characteristics. Pulmonary, intravenous, and other means of administration are among the delivery routes that may benefit from these small spherical particles.

    摘要翻译： 本发明提供均匀的低分子量有机分子的小球形颗粒，所述小球形颗粒具有均匀的形状，窄尺寸分布和平均直径为0.01-200μm。 本发明还提供了制备方法和使用小球形颗粒的方法。 这些小球形颗粒适用于需要输送具有均匀尺寸和良好空气动力学或流动特性的微米级或纳米尺寸颗粒的应用。 可以从这些小球形颗粒中受益的输送途径之中，肺，静脉内和其它施用方式。