公开(公告)号：US12090190B2

公开(公告)日：2024-09-17

申请号：US17885368

申请日：2022-08-10

申请人： Acerus Pharmaceuticals USA, LLC

发明人： Seymour Fein

IPC分类号： A61K38/095 ,  A61K9/00 ,  A61M15/08 ,  A61M11/00 ,  A61M11/06

CPC分类号： A61K38/095 ,  A61K9/0043 ,  A61M15/08 ,  A61M11/008 ,  A61M11/06

摘要： Disclosed is a family of intranasal spray dispensers for administering uniform low doses of desmopressin so as to achieve safe antidiuresis in human patients. The dispensers of the invention may be used in the treatment of nocturia, primary nocturnal enuresis, incontinence, urinary frequency, diabetes insipidus, or any disease or syndrome where desmopressin therapy is useful or where safe temporary suppression of urine production may lead to beneficial health effects or increased convenience in voiding control.

公开(公告)号：US20240139278A1

公开(公告)日：2024-05-02

申请号：US18392896

申请日：2023-12-21

申请人： XELLIA PHARMACEUTICALS APS

发明人： Ivona Jasprica ,  Marcel Lagedroste

IPC分类号： A61K38/095 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26

CPC分类号： A61K38/095 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26

摘要： The present disclosure relates to a ready-to-administer formulation of oxytocin, its pharmaceutically acceptable salts, or derivatives thereof, as well as products including the formulation. Specifically, the disclosure is directed to storage stable ready-to-administer formulations of oxytocin, method of producing such formulations and uses thereof.

公开(公告)号：US11957656B2

公开(公告)日：2024-04-16

申请号：US17080180

申请日：2020-10-26

申请人： The Trustees of Columbia University in the City of New York ,  Levo Therapeutics, Inc.

发明人： Lisa Cole Burnett ,  Dieter Egli ,  Rudolph L Leibel ,  Sara Cotter

IPC分类号： A61K31/366 ,  A61K31/277 ,  A61K31/352 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/4162 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/454 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5513 ,  A61K31/69 ,  A61K38/08 ,  A61K38/095 ,  A61K45/06 ,  A61P43/00 ,  A61K38/00

CPC分类号： A61K31/366 ,  A61K31/277 ,  A61K31/352 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/4162 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/454 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5513 ,  A61K31/69 ,  A61K38/08 ,  A61K38/095 ,  A61K45/06 ,  A61P43/00 ,  A61K38/00 ,  A61K31/277 ,  A61K2300/00 ,  A61K31/352 ,  A61K2300/00 ,  A61K31/403 ,  A61K2300/00 ,  A61K31/4035 ,  A61K2300/00 ,  A61K31/4015 ,  A61K2300/00 ,  A61K31/4162 ,  A61K2300/00 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/4375 ,  A61K2300/00 ,  A61K31/44 ,  A61K2300/00 ,  A61K31/454 ,  A61K2300/00 ,  A61K31/517 ,  A61K2300/00 ,  A61K31/522 ,  A61K2300/00 ,  A61K31/5513 ,  A61K2300/00 ,  A61K31/69 ,  A61K2300/00

摘要： The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).

公开(公告)号：US11931329B2

公开(公告)日：2024-03-19

申请号：US17817543

申请日：2022-08-04

申请人： Yamo Pharmaceuticals LLC

发明人： Steven Hoffman ,  John Rothman

IPC分类号： A61P25/22 ,  A61K9/00 ,  A61K9/20 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/4045 ,  A61K38/095 ,  A61K45/06

CPC分类号： A61K31/198 ,  A61K9/0053 ,  A61K31/197 ,  A61K31/4045 ,  A61K38/095 ,  A61K45/06 ,  A61P25/22

摘要： The present invention provides methods, compositions, and kits for treating anxiety-related disorders, including OCD and SAD, and for reducing anxiety, obsessive behavior, or compulsive behavior in subjects in need thereof.

公开(公告)号：US20240082344A1

公开(公告)日：2024-03-14

申请号：US18057065

申请日：2022-11-18

申请人： Ferring B.V.

发明人： Pascal DANGLAS ,  Michael REIDY ,  Paul KORNER ,  Sudarkodi ALAGARSAMY

IPC分类号： A61K38/095 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02

CPC分类号： A61K38/095 ,  A61K9/0043 ,  A61K9/08 ,  A61K47/02

摘要： This disclosure relates to a method of treating Prader-Willi Syndrome. The method includes administering to a patient in need thereof an effective amount of a composition containing a selective oxytocin receptor agonist or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230241156A1

公开(公告)日：2023-08-03

申请号：US18105293

申请日：2023-02-03

申请人： BIOVIE INC.

发明人： Penelope MARKHAM ,  Joseph M. PALUMBO

IPC分类号： A61K38/095 ,  A61K9/00

CPC分类号： A61K38/095 ,  A61K9/0019 ,  A61B5/14546

摘要： Provided are methods of treating a disease with arginine vasopressin or an analogue thereof that reduce the risk of hyponatremia. Specifically, the invention relates to the novel observation that subjects receiving co-administration of terlipressin and gabapentin or pregabalin have a high incidence of severe hyponatremia. The methods of the invention include either excluding subjects receiving gabapentin, gabapentin analogues, gabapentinoids, and other drugs known to cause hyponatremia from treatment with arginine vasopressin or analogues thereof; or reducing the subject's dose of gabapentin, gabapentin analogues, gabapentinoids, and other drugs known to cause hyponatremia prior to administration with arginine vasopressin or analogues thereof; or discontinuing administration of gabapentin, gabapentin analogues, gabapentinoids, and other drugs known to cause hyponatremia during the course of administration of arginine vasopressin or analogues thereof or reducing the dose of the arginine vasopressin or analogues thereof.

公开(公告)号：US20230121000A1

公开(公告)日：2023-04-20

申请号：US18055239

申请日：2022-11-14

申请人： Primo Pharmatech LLC

发明人： Zheng Wang

IPC分类号： A61K9/00 ,  A61K31/706 ,  A61K31/522 ,  A61K38/095 ,  A61K31/05 ,  A61K31/352 ,  A61K31/728 ,  A61K47/12 ,  A61K47/26 ,  A61K47/10

摘要： A solid dosage form for oral transmucosal delivery of an active pharmaceutical ingredient (API) is disclosed. Also provided are methods of treating a disease with the solid dosage form.

公开(公告)号：US11517581B2

公开(公告)日：2022-12-06

申请号：US16606877

申请日：2017-06-15

申请人： VERSITECH LIMITED ,  FUNDACION UNIVERSITARIA SAN ANTONIO

发明人： Shuofeng Yuan ,  Fuk Woo Jasper Chan ,  Kwok Yung Yuen ,  Helena Den Haan ,  Jorge Pena-García ,  José Pedro Cerón-Carrasco ,  Horacio Emilio Pérez-Sánchez

IPC分类号： A61K31/7048 ,  A61K38/095 ,  A61P31/14 ,  C12Q1/37

摘要： Methods and compounds for preventing and/or treating Zika virus (ZIKA) infection. And methods to screen for compound to prevent or treat Zika virus infection.

公开(公告)号：US11339204B2

公开(公告)日：2022-05-24

申请号：US16610701

申请日：2018-05-04

申请人： Imperial College Innovations Ltd

发明人： Thomas McKinnon ,  Mike Laffan

IPC分类号： C07K14/755 ,  A61K38/095 ,  A61P7/04 ,  A61K31/196 ,  A61K45/06

摘要： The present invention relates to novel truncated fragments of von Willebrand factor (VWF) and the use of such fragments and nucleic acids encoding such fragments in the treatment of von Willebrand disease (VWD) and haemophilia.

公开(公告)号：US20220152145A1

公开(公告)日：2022-05-19

申请号：US17348023

申请日：2021-06-15

申请人： Monash University

发明人： Michelle McIntosh ,  David Morton ,  Tomas Sou ,  Livesey Olerile ,  Richard Prankerd

IPC分类号： A61K38/095 ,  A61K9/16 ,  A61K9/00 ,  C07K7/16

摘要： This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.