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    PULMONARY DELIVERY OF SPHERICAL INSULIN MICROPARTICLES
    1.
    发明申请
    PULMONARY DELIVERY OF SPHERICAL INSULIN MICROPARTICLES 审中-公开
    脉冲胰岛素微生物的脉冲递送

    公开(公告)号：US20080026068A1

    公开(公告)日：2008-01-31

    申请号：US11736372

    申请日：2007-04-17

    申请人： Larry Brown ,  John McGeehan ,  Qin Yuanxi ,  Julia Rashba-Step ,  Terrence Scott

    发明人： Larry Brown ,  John McGeehan ,  Qin Yuanxi ,  Julia Rashba-Step ,  Terrence Scott

    IPC分类号： A61K9/14 ,  A61K38/28 ,  A61P11/00

    CPC分类号： A61K9/0075 ,  A61K38/28

    摘要： Compositions of spherical insulin particles having improved pulmonary application potentials and methods of forming and using these compositions are disclosed in the present application. In one clinical trial with 30 healthy male human subjects, no coughing was observed upon a single pulmonary administration of the spherical insulin particles at an insulin dose of 6.5 mg, nor during the 10-hour post dosing period.

    摘要翻译： 在本申请中公开了具有改善的肺部施用电位的球形胰岛素颗粒的组合物以及形成和使用这些组合物的方法。 在30名健康雄性人类受试者的一项临床试验中，在胰岛素剂量为6.5mg的单次肺部施用球素胰岛素颗粒时，也不在给药后10小时期间观察不到咳嗽。

    Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation
    5.
    发明申请
    Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation 有权
    通过控制相分离制备的小球形颗粒的制备方法，用途和组成

    公开(公告)号：US20050142206A1

    公开(公告)日：2005-06-30

    申请号：US10894430

    申请日：2004-07-19

    申请人： Larry Brown ,  John McGeehan ,  Julia Rashba-Step ,  Terrence Scott

    发明人： Larry Brown ,  John McGeehan ,  Julia Rashba-Step ,  Terrence Scott

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K38/27 ,  A61K38/28 ,  A61K38/54 ,  B01J13/06

    CPC分类号： B01J13/06 ,  A61K9/5026 ,  A61K9/5031 ,  A61K38/28

    摘要： The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 μm to about 200 μm.

    摘要翻译： 本发明涉及通过在单一液相中提供溶液来制备活性剂的小球形颗粒的方法。 单液相包含活性剂，相分离增强剂和第一溶剂。 在溶液中以受控的速率诱导相变，引起活性剂的液固相分离并形成固相和液相。 固相包含活性剂的固体小球形颗粒。 液相包含相分离增效剂和溶剂。 小球形颗粒基本上是球形的并且具有约0.01μm至约200μm的尺寸。

    Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation
    9.
    发明授权
    Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation 有权
    通过控制相分离制备的小球形颗粒的制备方法，用途和组成

    公开(公告)号：US08075919B2

    公开(公告)日：2011-12-13

    申请号：US10894430

    申请日：2004-07-19

    申请人： Larry Brown ,  John K. McGeehan ,  Julia Rashba-Step ,  Terrence L. Scott

    发明人： Larry Brown ,  John K. McGeehan ,  Julia Rashba-Step ,  Terrence L. Scott

    IPC分类号： A61K9/16

    CPC分类号： B01J13/06 ,  A61K9/5026 ,  A61K9/5031 ,  A61K38/28

    摘要： The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 μm to about 200 μm.

    摘要翻译： 本发明涉及通过在单一液相中提供溶液来制备活性剂的小球形颗粒的方法。 单液相包含活性剂，相分离增强剂和第一溶剂。 在溶液中以受控的速率诱导相变，引起活性剂的液固相分离并形成固相和液相。 固相包含活性剂的固体小球形颗粒。 液相包含相分离增效剂和溶剂。 小球形颗粒基本上是球形的并且具有约0.01μm至约200μm的尺寸。

    Methods for encapsulating small spherical particles prepared by controlled phase separation
    10.
    发明申请
    Methods for encapsulating small spherical particles prepared by controlled phase separation 审中-公开
    包封通过控制相分离制备的小球形颗粒的方法

    公开(公告)号：US20050170005A1

    公开(公告)日：2005-08-04

    申请号：US11033780

    申请日：2005-01-12

    申请人： Julia Rashba-Step ,  Ramin Darvari ,  Terrence Scott

    发明人： Julia Rashba-Step ,  Ramin Darvari ,  Terrence Scott

    IPC分类号： A61K9/16 ,  A61K9/50

    CPC分类号： A61K9/0019 ,  A61K9/10 ,  A61K9/1647 ,  A61K9/1688 ,  A61K9/1694

    摘要： The present invention relates to methods of making and compositions of microencapsulated small particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is then subjected to a liquid-solid phase separation to cause the active agent to form solid spherical small particles in the solid phase while the PSEA and solvent comprising the liquid phase. The spherical small particles formed are then microencapsulated within a polymeric matrix using an emulsion/evaporation process.

    摘要翻译： 本发明涉及制备活性剂微胶囊化小颗粒的方法和组合物。 根据生产方法，将活性剂溶解在含有溶解的相分离增强剂（PSEA）的水溶性或水溶性溶剂中以形成单一液相中的溶液。 然后将溶液进行液固相分离，使活性剂在固相中形成固体球形小颗粒，而PSEA和溶剂包含液相。 然后使用乳液/蒸发方法将形成的球形小颗粒微胶囊化在聚合物基体内。