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公开(公告)号:US07785784B2
公开(公告)日:2010-08-31
申请号:US11186660
申请日:2005-07-21
申请人: David T. Shima , Pericles Calias , Gregory S. Robinson , John P. Wing , Lori M. Mullin , Lillian M. Smith , Ervin Sinani
发明人: David T. Shima , Pericles Calias , Gregory S. Robinson , John P. Wing , Lori M. Mullin , Lillian M. Smith , Ervin Sinani
CPC分类号: C12Q1/6837 , C12Q1/6816 , C12Q2561/125 , C12Q2561/101 , C12Q2525/205 , C12Q2533/107 , C12Q2537/125 , C12Q2531/113 , C12Q2525/155
摘要: The invention provides methods and compositions for detecting and/or quantifying modified nucleic acid oligonucleotides. These methods and compositions are useful for detecting and quantifying diagnostic and/or therapeutic synthetic modified oligonucleotides, such as aptamers, RNAi, siRNA, antisense oligonucleotides or ribozymes in a biological sample.
摘要翻译: 本发明提供了用于检测和/或定量修饰的核酸寡核苷酸的方法和组合物。 这些方法和组合物可用于检测和定量诊断和/或治疗合成修饰的寡核苷酸,例如生物样品中的适体,RNAi,siRNA,反义寡核苷酸或核酶。