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    Compounds and methods for the treatment of bacterial dysentery using antibiotics and toxin binding oligosaccharide compositions
    3.
    发明授权
    Compounds and methods for the treatment of bacterial dysentery using antibiotics and toxin binding oligosaccharide compositions 失效
    使用抗生素和毒素结合寡糖组合物治疗细菌性痢疾的化合物和方法

    公开(公告)号：US06224891B1

    公开(公告)日：2001-05-01

    申请号：US09255709

    申请日：1999-02-23

    申请人： David John Rafter ,  Robert Murray Ratcliffe ,  Bradley G. Thompson ,  Glen D. Armstrong

    发明人： David John Rafter ,  Robert Murray Ratcliffe ,  Bradley G. Thompson ,  Glen D. Armstrong

    IPC分类号： A01N2526

    CPC分类号： A61K31/70 ,  A61K45/06 ,  A61K47/52 ,  Y02A50/473 ,  Y02A50/475 ,  A61K2300/00

    摘要： This invention relates to the treatment of diarrhea and related conditions caused by pathogenic E. coli infection. More specifically, this invention is drawn to the unexpected discovery that by administering a composition which binds and removes the shiga like toxins (SLT) produced by pathogenic E. coli whenever an antibiotic is administered, improved treatment is provided. Novel compositions containing both antibiotic and toxin binding composition and methods of treatment which use simultaneous administration toxin binding composition whenever antibiotic is administered are provided. These compositions and methods kill the enteric E. coli organisms which produce the conditions and neutralize the SLT produced by the organisms and/or released from the organisms when they are killed. Thus, these compositions and methods are better able to ameliorate the symptoms of the infection and inhibit progression of this infection into hemolytic uremic syndrome (HUS) than conventional treatment.

    摘要翻译： 本发明涉及由病原性大肠杆菌感染引起的腹泻及相关病症的治疗。 更具体地，本发明涉及意想不到的发现：通过施用结合和除去由致病性大肠杆菌产生的志贺样毒素（SLT）的组合物，每当施用抗生素时，提供改进的治疗。 提供了含抗生素和毒素结合组合物的新型组合物和每当施用抗生素时同时施用毒素结合组合物的治疗方法。 这些组合物和方法杀死产生条件的肠道大肠杆菌生物体，并中和由生物体产生的SLT和/或当它们被杀死时从生物体中释放出来。 因此，这些组合物和方法能够比常规治疗更好地改善感染的症状并抑制这种感染进入溶血性尿毒综合征（HUS）的进展。

    Staffing-based percentage-allocation routing using real-time data
    6.
    发明授权
    Staffing-based percentage-allocation routing using real-time data 有权
    基于人员配置的百分比路由使用实时数据

    公开(公告)号：US06584191B1

    公开(公告)日：2003-06-24

    申请号：US09384789

    申请日：1999-08-27

    申请人： Kevin McPartlan ,  Edward Komissarchik ,  Lauren O'Brien ,  Robert Hayes ,  Katherine McElroy ,  John Rafter ,  Gary Sorensen ,  David Glassman

    发明人： Kevin McPartlan ,  Edward Komissarchik ,  Lauren O'Brien ,  Robert Hayes ,  Katherine McElroy ,  John Rafter ,  Gary Sorensen ,  David Glassman

    IPC分类号： H04M300

    CPC分类号： H04M3/5232 ,  H04M3/5238

    摘要： A method and apparatus are provided for performing staffing-based percentage-allocation routing using real-time data. According to one aspect of the present invention, transaction allocation is determined using both scheduled and actual handling resources. Actual handling resources associated with each of several transaction processing systems, such as automatic call distributors (ACDs), are measured at times t and t+n. Scheduled handling resources associated with each of the transaction processing systems for times t and t+n are also identified. Then, estimated handling resources are calculated for each of the transaction processing systems for time t+n based upon the actual handling resources and the scheduled handling resources. Finally, based upon the estimated handling resources, transaction allocations for each of the transaction processing systems are determined. According to another aspect of the present invention, a virtual call center is provided. The virtual call center includes a wide area network (WAN), multiple call centers coupled to the WAN, and an allocation controller coupled to the WAN. Each of the call centers includes a transaction processing system. The allocation controller is configured to calculate allocation sets for one or more forecast periods based upon scheduled staffing levels and actual staffing level information received from the transaction processing systems. The allocation sets include percent allocations for each of the transaction processing systems. The allocation controller is additionally configured to balance call distribution among the transaction processing systems by uploading the allocation sets to an inter-exchange carrier interface.

    摘要翻译： 提供一种用于使用实时数据执行基于人员配置的百分比分配路由的方法和装置。 根据本发明的一个方面，使用预定和实际处理资源来确定事务分配。 在时间t和t + n处测量与诸如自动呼叫分配器（ACD）的几个交易处理系统中的每一个相关联的实际处理资源。 还识别与时间t和t + n的每个事务处理系统相关联的计划处理资源。 然后，基于实际的处理资源和调度的处理资源，针对时间t + n的每个事务处理系统计算估计的处理资源。 最后，基于估计的处理资源，确定每个交易处理系统的交易分配。 根据本发明的另一方面，提供一种虚拟呼叫中心。 虚拟呼叫中心包括广域网（WAN），耦合到WAN的多个呼叫中心以及耦合到WAN的分配控制器。 每个呼叫中​​心包括交易处理系统。 分配控制器被配置为基于从事务处理系统接收到的预定人员配置级别和实际人员配置级别信息来计算一个或多个预测周期的分配集。 分配集包括每个事务处理系统的百分比分配。 分配控制器还被配置为通过将分配集上传到交换机之间的载体接口来平衡事务处理系统中的呼叫分配。