公开(公告)号：US08728823B2

公开(公告)日：2014-05-20

申请号：US12743042

申请日：2008-11-24

申请人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

发明人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

IPC分类号： G01N33/00 ,  G01N33/566

CPC分类号： G01N33/57423 ,  G01N2800/50 ,  G01N2800/52

摘要： A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

摘要翻译： 描述了一种用于检测肺癌的方法，包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了用于预测受试者中发展肺癌的风险的方法，包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了监测肺癌治疗成功的方法，其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平，以与从受试者获得的先前水平进行比较。 多变量分析可纳入这些方法，评估年龄，性别，吸烟史，吸烟状况，吸烟家族史，教育水平，COPD，社会经济状况，体重指数和肺功能等临床或人口学危险因素。 描述了用于进行这种方法的套件。

公开(公告)号：US20100248290A1

公开(公告)日：2010-09-30

申请号：US12743042

申请日：2008-11-24

申请人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

发明人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

IPC分类号： G01N33/68 ,  C12Q1/02

CPC分类号： G01N33/57423 ,  G01N2800/50 ,  G01N2800/52

摘要： A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment with curative intent is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with the a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

摘要翻译： 描述了一种用于检测肺癌的方法，包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了用于预测受试者中发展肺癌的风险的方法，包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。 另外，描述了以治愈意图监测肺癌治疗成功的方法，其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平，以与从受试者获得的先前水平进行比较 。 多变量分析可纳入这些方法，评估年龄，性别，吸烟史，吸烟状况，吸烟家族史，教育水平，COPD，社会经济状况，体重指数和肺功能等临床或人口学危险因素。 描述了用于进行这种方法的套件。

公开(公告)号：US6075631A

公开(公告)日：2000-06-13

申请号：US926332

申请日：1997-09-05

申请人： Krishna Bala ,  Gee-Kung Chang ,  Georgios Nicos Ellinas ,  Michael Post ,  Chien-Chung Shen ,  John Yee-Keung Wei

发明人： Krishna Bala ,  Gee-Kung Chang ,  Georgios Nicos Ellinas ,  Michael Post ,  Chien-Chung Shen ,  John Yee-Keung Wei

IPC分类号： H04B10/02 ,  H04J14/00 ,  H04J14/02 ,  H04Q3/52 ,  H04Q11/00

CPC分类号： H04Q11/0001 ,  H04J14/0227 ,  H04J14/0241 ,  H04J14/0282 ,  H04J14/0283 ,  H04J14/0284

摘要： A method of reconfiguring a multi-wavelength communication network. The transition includes determining the union of the old and new topologies. During at least the start of the transition, the network supports the union topology. New connections are connected according to the new topology, and the old topology, as its connections expire, is gradually removed. In allocating wavelengths to a new topology, two algorithms are developed which assign wavelengths which do not color clash with the wavelength assignments of the old topology.

摘要翻译： 一种重新配置多波长通信网络的方法。 转型包括确定新旧拓扑结合。 在至少开始转换期间，网络支持联合拓扑。 根据新拓扑连接新连接，并且随着其连接到期，旧拓扑逐渐被删除。 在将波长分配到新拓扑中时，开发了两种算法，其分配不与旧拓扑的波长分配进行颜色冲突的波长。