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    Methods for detecting lung cancer and monitoring treatment response
    5.
    发明授权
    Methods for detecting lung cancer and monitoring treatment response 有权
    检测肺癌的方法和监测治疗反应

    公开(公告)号：US08728823B2

    公开(公告)日：2014-05-20

    申请号：US12743042

    申请日：2008-11-24

    申请人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

    发明人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

    IPC分类号： G01N33/00 ,  G01N33/566

    CPC分类号： G01N33/57423 ,  G01N2800/50 ,  G01N2800/52

    摘要： A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

    摘要翻译： 描述了一种用于检测肺癌的方法，包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了用于预测受试者中发展肺癌的风险的方法，包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了监测肺癌治疗成功的方法，其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平，以与从受试者获得的先前水平进行比较。 多变量分析可纳入这些方法，评估年龄，性别，吸烟史，吸烟状况，吸烟家族史，教育水平，COPD，社会经济状况，体重指数和肺功能等临床或人口学危险因素。 描述了用于进行这种方法的套件。

    APPARATUS AND METHODS FOR CHARACTERIZATION OF LUNG TISSUE BY RAMAN SPECTROSCOPY
    6.
    发明申请
    APPARATUS AND METHODS FOR CHARACTERIZATION OF LUNG TISSUE BY RAMAN SPECTROSCOPY 审中-公开
    拉曼光谱法鉴定肺组织的装置及方法

    公开(公告)号：US20130231573A1

    公开(公告)日：2013-09-05

    申请号：US13521218

    申请日：2011-01-21

    申请人： Haishan Zeng ,  Michael Short ,  Stephen Lam ,  Annette McWilliams

    发明人： Haishan Zeng ,  Michael Short ,  Stephen Lam ,  Annette McWilliams

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0075 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/65

    摘要： Near-infrared Raman spectroscopy can be applied to identify preneoplastic lesions of the bronchial tree. Real-time in vivo Raman spectra of lung tissues may be obtained with a fiber optic catheter passed down the instrument channel of a bronchoscope. Using prototype apparatus, preneoplastic lesions were detected with sensitivity and specificity of 96 and 91% respectively. The use of Raman spectroscopy apparatus and methods in conjunction with other bronchoscopy imaging modalities can substantially reduce the number of false positive results.

    摘要翻译： 近红外拉曼光谱可用于鉴定支气管树瘤的肿瘤前病变。 肺组织的实时体内拉曼光谱可以通过沿支气管镜仪器通道向下传播的光纤导管获得。 使用原型装置，分别检测到96和91％的敏感性和特异性的癌前病变。 使用拉曼光谱设备和方法与其他支气管镜检查成像模式联合可以大大减少假阳性结果的数量。