公开(公告)号：US07223766B2

公开(公告)日：2007-05-29

申请号：US10811428

申请日：2004-03-26

Applicant: Sundeep Dugar ,  Sarvajit Chakravarty ,  Aurelia Conte ,  Jonathan Axon ,  Glenn McEnroe ,  Alison Murphy

Inventor： Sundeep Dugar ,  Sarvajit Chakravarty ,  Aurelia Conte ,  Jonathan Axon ,  Glenn McEnroe ,  Alison Murphy

IPC: A61K31/517 ,  C07D239/70

CPC classification number: C07D487/04 ,  A61K31/517 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04

Abstract: Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGFβ activity.

Abstract translation: 其中嘧啶核在5和6位桥连并且在2和4位被含有芳族部分的取代基进一步取代的化合物可用于治疗通过抑制TGFbeta活性而改善的类风湿关节炎的受试者。

公开(公告)号：US20060281763A1

公开(公告)日：2006-12-14

申请号：US11390980

申请日：2006-03-27

Applicant: Jonathan Axon ,  Sarvajit Chakravarty ,  Barry Hart ,  Glenn McEnroe ,  Alison Murphy ,  Karen Pontius ,  Peijue Sheng ,  Xiaojing Wang ,  Shanthi Yellapregada

Inventor： Jonathan Axon ,  Sarvajit Chakravarty ,  Barry Hart ,  Glenn McEnroe ,  Alison Murphy ,  Karen Pontius ,  Peijue Sheng ,  Xiaojing Wang ,  Shanthi Yellapregada

IPC: C07D403/14 ,  C07D403/02 ,  A61K31/506

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D495/04

Abstract: Certain appropriately substituted forms of pyrimidine having a pyridylamine group at C-4 of the pyrimidine and an amide group on the pyridine ring are useful in the treatment of conditions associated with excessive TGFβ activity.

Abstract translation: 在嘧啶的C-4处具有吡啶基胺基的嘧啶的某些适当取代的形式和吡啶环上的酰胺基可用于治疗与过量TGFbeta活性相关的病症。

公开(公告)号：US20070066632A1

公开(公告)日：2007-03-22

申请号：US11391726

申请日：2006-03-27

Applicant: Barry Hart ,  Sarvajit Chakravarty ,  Jonathan Axon ,  Alison Murphy ,  Glenn McEnroe

Inventor： Barry Hart ,  Sarvajit Chakravarty ,  Jonathan Axon ,  Alison Murphy ,  Glenn McEnroe

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D471/04

Abstract: Certain appropriately substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with excessive TGFβ activity and certain viral disorders.

Abstract translation: 在嘧啶环的C-4具有酰胺取代的吡啶基胺基团的某些适当取代的稠合双环嘧啶化合物可用于治疗与过量TGFbeta活性和某些病毒性疾病相关的病症。

公开(公告)号：US20050004143A1

公开(公告)日：2005-01-06

申请号：US10811428

申请日：2004-03-26

Applicant: Sundeep Dugar ,  Sarvajit Chakravarty ,  Aurelia Conte ,  Jonathan Axon ,  Glenn McEnroe ,  Alison Murphy

Inventor： Sundeep Dugar ,  Sarvajit Chakravarty ,  Aurelia Conte ,  Jonathan Axon ,  Glenn McEnroe ,  Alison Murphy

IPC: A61K31/517 ,  A61K31/519 ,  C07D239/94 ,  C07D401/12 ,  C07D487/02 ,  C07D487/04 ,  C07D491/02 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/517 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04

Abstract: Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with conditions ameliorated by inhibition of TGFβ activity.

Abstract translation: 其中嘧啶核在5和6位上桥连并且在2和4位被含有芳族部分的取代基进一步取代的化合物可用于治疗受抑制TGFbeta活性改善的病症的受试者。