Abstract:
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
Abstract:
An umbrella having a light source mounted inside the umbrella handle and controlled by a slide switch to give off light through a refractor around the umbrella shaft, wherein the umbrella shaft is a transparent, solid, polygonal rod having a refracting area for refracting the light of the light source toward the ribs and umbrella cover of the umbrella.
Abstract:
A client computer program provides instructions for a processor to locate and retrieve rich media and HTML files for running in a three-dimensional graphical user interface. The program provides instructions for the processor to generate a three-dimensional (3D) graphical user interface on a display. Then, the processor generates a metaphorical user object for navigating and interacting in the three dimensions within the environment via navigational and interactional inputs, respectively, from a user. The processor also integrates an HTML object into the environment, and interacts the user object with the HTML object in response to an interactional input from the user. Preferably, the processor generates one or more additional user objects for additional users. Each of the additional user objects can also interact with the HTML object, the first user object and/or each other within the environment in response to interactional inputs from the additional users. In addition, the first user object may interact with any or all of the additional user objects in response to interactional inputs from the first user. The interactional inputs may be proxy expressions from one user to another.
Abstract:
There is disclosed 103 novel methylation-altered DNA sequences (“marker sequences”) that have distinct methylation patterns in cancer, compared to normal tissue. In many instances, these marker sequences represent novel sequences not found in the GenBank data base, and none of these marker sequences have previously been characterized with respect to their methylation pattern in human cancers including, but not limited to those of bladder and prostate. These 103 sequences have utility as diagnostic, prognostic and therapeutic markers in the treatment of human cancer, and as reagents in kits for detecting methylated CpG-containing nucleic acids.
Abstract:
An automatic umbrella including an inside cap at the top of the umbrella shaft thereof, a top runner mounted around the umbrella shaft, an open control spring mounted between the inside cap and the top runner and compressed to preserve energy for opening the umbrella when the umbrella is collapsed, a collapse control spring compressed and retained in the compressed position by means of the operation of the hook of a locating device on the top end of the bottom shaft of the umbrella shaft, and the operation of the detent of a release control device inside the umbrella shaft, to preserve energy for collapsing the umbrella when the umbrella is opened, and a control block with a push plate moved vertically to actuate the release control device in automatically opening/closing the umbrella, and a bottom runner having a hook hooked on the umbrella shaft for allowing the umbrella to be operated manually when the hook of the bottom runner is released.
Abstract:
There is disclosed 103 novel methylation-altered DNA sequences (“marker sequences”) that have distinct methylation patterns in cancer, compared to normal tissue. In many instances, these marker sequences represent novel sequences not found in the GenBank data base, and none of these marker sequences have previously been characterized with respect to their methylation pattern in human cancers including, but not limited to those of bladder and prostate. These 103 sequences have utility as diagnostic, prognostic and therapeutic markers in the treatment of human cancer, and as reagents in kits for detecting methylated CpG-containing nucleic acids.
Abstract:
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
Abstract:
A folding collapsible frame assembly for an automatic folding umbrella, which includes a lower shaft, an upper shaft made to slide in the upper shaft, a collapse control spring, a lock ring moved to lock the collapse control spring in the compressed condition as the umbrella is opened, a stretch control spring controlled by a bottom spring on the handle of the umbrella to automatically push the umbrella into the open condition, a guide control mechanism controlled by a control bottom on the handle of the umbrella to release the lock ring from the collapse control spring for allowing the umbrella to be collapsed automatically.