-
1.发明申请COMPOSITION WITH IMPROVED SKIN PENETRATION FOR TRANSDERMAL DELIVERY OF TOLTERODINE 有权具有改善皮肤渗透性的组合物，用于转铁蛋白公开(公告)号：US20130046026A1
公开(公告)日：2013-02-21
申请号：US13579824
申请日：2011-02-17
申请人： Yong Youn Hwang , Won-Jae Choi , Jae-Sun Kim , Yeo-Jin Park , Joon-Gyo Oh , Bong-Yong Lee , Hae-In Rhee , Jong-Seob Im
发明人： Yong Youn Hwang , Won-Jae Choi , Jae-Sun Kim , Yeo-Jin Park , Joon-Gyo Oh , Bong-Yong Lee , Hae-In Rhee , Jong-Seob Im
IPC分类号： A61K31/137 , A61P13/10 , C07C211/27
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/167 , A61K2300/00
摘要： Disclosed is a composition for transdermal administration containing tolterodine. The composition comprises lidocaine or a pharmaceutically acceptable salt thereof to achieve enhanced skin penetration. The composition enhances the skin penetration of tolterodine. Therefore, a successful commercial application of a tolterodine-containing transdermal preparation based on the composition can be expected.
摘要翻译： 公开了含有托特罗定的透皮给药组合物。 组合物包含利多卡因或其药学上可接受的盐以实现增强的皮肤渗透。 组合物增强托特罗定的皮肤渗透。 因此，可以预期基于组合物成功地商业应用含有托特罗定的透皮制剂。
-
2.发明申请LYOPHILIZED PHARMACEUTICAL COMPOSITION WITH IMPROVED STABILITY CONTAINING TAXANE DERIVATIVES, AND METHOD OF MANUFACTURING THE SAME 审中-公开含有TAXANE衍生物的改进的稳定性的LYOPHILIZED药物组合物及其制备方法公开(公告)号：US20100305202A1
公开(公告)日：2010-12-02
申请号：US12744164
申请日：2008-11-21
申请人： Yong Youn Hwang , Woo Jae Jang , Joon-Gyo Oh , Nam Ho Kim , Jae-Sun Kim , Key An Um
发明人： Yong Youn Hwang , Woo Jae Jang , Joon-Gyo Oh , Nam Ho Kim , Jae-Sun Kim , Key An Um
IPC分类号： A61K31/337 , A61P35/00
摘要： The present invention relates to a lyophilized pharmaceutical composition for injection having superior storage stability comprising a taxoid, and a method thereof. More specifically, the present invention relates to a lyophilized pharmaceutical composition for injection having improved solubility and stability of dilution compared to the conventional preparations by dissolving a water-insoluble taxoid in distilled water added with a hydrophilic polymer such as hydroxypropylmethyl cellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) cyclodextrin (CD), and lyophilizing the mixture and a method thereof.
摘要翻译： 本发明涉及具有优异的储存稳定性的冻干药物组合物，其包含紫杉烷类及其方法。 更具体地，本发明涉及一种用于注射的冻干药物组合物，其与常规制剂相比，通过将水不溶性紫杉烷溶解在加入亲水性聚合物如羟丙基甲基纤维素（HPMC），聚乙烯的蒸馏水中而具有改善的溶解度和稳定性 乙二醇（PEG）或聚乙烯吡咯烷酮（PVP）环糊精（CD），并冻干该混合物及其方法。
-
3.发明授权Composition with improved skin penetration for transdermal delivery of tolterodine 有权具有改善皮肤渗透性的组合物，用于透明递送托特罗定公开(公告)号：US08809401B2
公开(公告)日：2014-08-19
申请号：US13579824
申请日：2011-02-17
申请人： Yong Youn Hwang , Won-Jae Choi , Jae-Sun Kim , Yeo-Jin Park , Joon-Gyo Oh , Bong-Yong Lee , Hae-In Rhee , Jong-Seob Im
发明人： Yong Youn Hwang , Won-Jae Choi , Jae-Sun Kim , Yeo-Jin Park , Joon-Gyo Oh , Bong-Yong Lee , Hae-In Rhee , Jong-Seob Im
IPC分类号： A61K31/05
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/167 , A61K2300/00
摘要： Disclosed is a composition for transdermal administration containing tolterodine. The composition comprises lidocaine or a pharmaceutically acceptable salt thereof to achieve enhanced skin penetration. The composition enhances the skin penetration of tolterodine. Therefore, a successful commercial application of a tolterodine-containing transdermal preparation based on the composition can be expected.
摘要翻译： 公开了含有托特罗定的透皮给药组合物。 组合物包含利多卡因或其药学上可接受的盐以实现增强的皮肤渗透。 组合物增强托特罗定的皮肤渗透。 因此，可以预期基于组合物成功地商业应用含有托特罗定的透皮制剂。
-
4.发明授权Stable pharmaceutical composition containing docetaxel and a method of manufacturing the same 失效含有多西紫杉醇的稳定的药物组合物及其制造方法公开(公告)号：US08791152B2
公开(公告)日：2014-07-29
申请号：US12301700
申请日：2007-05-22
申请人： Nam Ho Kim , Jin Young Lee , Jae-Sun Kim , Nam Kyu Lee , Woo Jae Jang , Joon Gyo Oh , Yoon-Jung Lee , Woong Sik Kim , Jin-Heung Sung , Key An Um
发明人： Nam Ho Kim , Jin Young Lee , Jae-Sun Kim , Nam Kyu Lee , Woo Jae Jang , Joon Gyo Oh , Yoon-Jung Lee , Woong Sik Kim , Jin-Heung Sung , Key An Um
IPC分类号： A61K31/335
CPC分类号： A61K9/0019 , A61K9/19 , A61K31/337 , A61K31/724 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/40 , A61K2300/00
摘要： The present invention relates to a stable pharmaceutical composition for injection containing docetaxel and a method of preparing the same. More particularly, the present invention relates to a pharmaceutical composition for injection containing docetaxel having better storage stability than conventional medications, which is prepared by dissolving docetaxel, a water-insoluble compound, in distilled water after mixing it with cyclodextrin (CD) and a water-soluble polymer such as hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) and lyophilizing the mixture, and a method of preparing the same.
摘要翻译： 本发明涉及含有多西紫杉醇的稳定的注射用药物组合物及其制备方法。 更具体地说，本发明涉及含有多西紫杉醇的药物组合物，其具有比常规药物更好的储存稳定性，其通过将多巴紫杉醇，水不溶性化合物与环糊精（CD）和水混合后在蒸馏水中溶解而制备 可溶性聚合物如羟丙基甲基纤维素（HPMC），聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP），并将混合物冷冻干燥及其制备方法。
-
5.发明申请LYOPHILIZED PHARMACEUTICAL COMPOSITION WITH IMPROVED RECONSTITUTION TIME CONTAINING TAXANE DERIVATIVES AND METHOD OF MANUFACTURING THE SAME 审中-公开具有改进的包含TAXANE衍生物的重新构建时间的LYOPHILIZED药物组合物及其制备方法公开(公告)号：US20100267817A1
公开(公告)日：2010-10-21
申请号：US12744151
申请日：2008-11-21
申请人： Woo Jae Jang , Joon-Gyo Oh , Young Youn Hwang , Won Jae Choi , Key An Um
发明人： Woo Jae Jang , Joon-Gyo Oh , Young Youn Hwang , Won Jae Choi , Key An Um
IPC分类号： A61K31/337 , A61P43/00
摘要： The present invention relates to a lyophilized composition with an improved reconstitution time comprising a taxoid and a method thereof. More specifically, the present invention relates to a lyophilized composition with an improved reconstitution time prepared by mixing and dissolving a taxoid; cyclodextrin (CD); a hydrophilic polymer selected from the group consisting of hydroxypropylmethyl CeIIuIoSe (HPMC), polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP); and a bulking agent of saccharides in water for injection; and lyophilizing the mixture, and a method thereof.
摘要翻译： 本发明涉及具有改进的重构时间的冻干组合物，其包含紫杉烷及其方法。 更具体地，本发明涉及通过混合和溶解紫杉烷制备的具有改进的重构时间的冻干组合物; 环糊精（CD）; 选自羟丙基甲基CeIIuIoSe（HPMC），聚乙二醇（PEG）和聚乙烯吡咯烷酮（PVP）的亲水性聚合物; 和糖类在注射用水中的填充剂; 并将混合物冻干，及其方法。
-
公开(公告)号：US09585862B2
公开(公告)日：2017-03-07
申请号：US14118985
申请日：2012-05-21
申请人： Yong-youn Hwang , Won-Jae Choi , Jae-Sun Kim , Won-No Youn , Yeo-Jin Park , Joon-gyo Oh , JongSeob Im
发明人： Yong-youn Hwang , Won-Jae Choi , Jae-Sun Kim , Won-No Youn , Yeo-Jin Park , Joon-gyo Oh , JongSeob Im
CPC分类号： A61K31/325 , A61K9/7061 , A61K9/7084 , A61K31/27 , A61L15/44 , A61L15/58 , A61L2300/00
摘要： The present invention relates to a rivastigmine-containing patch having improved storage stability and proper release property.
摘要翻译： 本发明涉及具有改善的储存稳定性和适当的释放性能的含有利伐斯的明的贴剂。
-
公开(公告)号：US09155715B2
公开(公告)日：2015-10-13
申请号：US13381328
申请日：2010-05-27
申请人： Yong Youn Hwang , Won Jae Choi , Yeo-Jin Park , Joon-gyo Oh
发明人： Yong Youn Hwang , Won Jae Choi , Yeo-Jin Park , Joon-gyo Oh
IPC分类号： C07C211/00 , A61L15/16 , A61K31/137 , A61K9/06 , A61K9/70 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/38
CPC分类号： A61K31/137 , A61K9/06 , A61K9/7061 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/38
摘要： A transdermal composition comprising tolterodine having improved storage stability is disclosed. The transdermal composition comprising tolterodine contains an antioxidant to stabilize tolterodine and can be stored for a long period of time.
摘要翻译： 公开了包含具有改善的储存稳定性的托特罗定的透皮组合物。 包含托特罗定的透皮组合物含有抗氧化剂以稳定托特罗定并且可以长期储存。
-
8.发明申请COMPOSITION WITH LOW SKIN IRRITATION FOR TRANSDERMAL DELIVERY OF TOLTERODINE 审中-公开具有低皮肤刺激用于转铁蛋白转运的组合物公开(公告)号：US20130046025A1
公开(公告)日：2013-02-21
申请号：US13579852
申请日：2011-02-17
申请人： Yong Youn Hwang , Won-Jae Choi , Jae-Sun Kim , Yeo-Jin Park , Joon-Gyo Oh , Bong-Yong Lee , Hae-In Rhee , Jong-Seob Im
发明人： Yong Youn Hwang , Won-Jae Choi , Jae-Sun Kim , Yeo-Jin Park , Joon-Gyo Oh , Bong-Yong Lee , Hae-In Rhee , Jong-Seob Im
IPC分类号： A61K31/137 , A61P13/10 , A61P17/00 , A61K31/167
CPC分类号： A61K31/137 , A61K9/7061 , A61K47/44
摘要： Disclosed is a composition for transdermal administration containing tolterodine. The composition comprises at least one essential oil as an abirritant to minimize skin irritation caused by tolterodine. The composition relieves skin irritation caused by tolterodine. Therefore, a successful commercial application of a tolterodine-containing transdermal preparation based on the composition can be expected.
摘要翻译： 公开了含有托特罗定的透皮给药组合物。 组合物包含至少一种作为刺激物的精油，以最小化由托特罗定引起的皮肤刺激。 该组合物可减轻托特罗定引起的皮肤刺激。 因此，可以预期基于组合物成功地商业应用含有托特罗定的透皮制剂。
-
公开(公告)号：US20120123162A1
公开(公告)日：2012-05-17
申请号：US13381328
申请日：2010-05-27
申请人： Yong Youn Hwang , Won Jae Choi , Yeo Jin Park , Joon-gyo Oh
发明人： Yong Youn Hwang , Won Jae Choi , Yeo Jin Park , Joon-gyo Oh
IPC分类号： C07C211/26
CPC分类号： A61K31/137 , A61K9/06 , A61K9/7061 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/38
摘要： A transdermal composition comprising tolterodine having improved storage stability is disclosed. The transdermal composition comprising tolterodine contains an antioxidant to stabilize tolterodine and can be stored for a long period of time.
摘要翻译： 公开了包含具有改善的储存稳定性的托特罗定的透皮组合物。 包含托特罗定的透皮组合物含有抗氧化剂以稳定托特罗定并且可以长期储存。
-
10.发明申请公开(公告)号：US20100099773A1
公开(公告)日：2010-04-22
申请号：US12444080
申请日：2007-11-22
申请人： Jae-Sun Kim , Nam Ho Kim , Jin Young Lee , Nam Kyu Lee , Joon Gyo Oh , Yong Youn Hwang , Dong-Chul Shin , Yoon-Jung Lee , Key An Um , Sun Ho Kim , Jin-Heung Sung
发明人： Jae-Sun Kim , Nam Ho Kim , Jin Young Lee , Nam Kyu Lee , Joon Gyo Oh , Yong Youn Hwang , Dong-Chul Shin , Yoon-Jung Lee , Key An Um , Sun Ho Kim , Jin-Heung Sung
IPC分类号： A61K31/135 , A61P25/00
CPC分类号： A61K31/135 , A61K47/6951 , B82Y5/00 , C08B37/0015
摘要： The present invention relates to a sibutramine-containing inclusion complex having superior storage stability, and particularly to a pharmaceutically stable inclusion complex suitable for the drug formulation, which prepared by reacting a sibutramine (N,N-dimethyl-1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutylamine) of Formula 1 and beta-cyclodextrin in a predetermined ratio, its preparation method and a pharmaceutical composition comprising the same.
摘要翻译： 本发明涉及具有优异储存稳定性的西布曲明含量复合物，特别涉及适用于药物制剂的药学上稳定的包合络合物，其通过使西布曲明（N，N-二甲基-1- [1-（4 - 氯苯基） - 环丁基] -3-甲基丁胺）和β-环糊精，其制备方法和包含其的药物组合物。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.013 秒)