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公开(公告)号：US07521192B2
公开(公告)日：2009-04-21
申请号：US09971228
申请日：2001-10-03
申请人： X. Charlene Liao , Esteban Masuda , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Ying-Ping Jiang , Collin Spencer
发明人： X. Charlene Liao , Esteban Masuda , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Ying-Ping Jiang , Collin Spencer
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , G01N33/56972 , G01N2333/4703 , G01N2500/10
摘要： The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
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公开(公告)号：US07118854B2
公开(公告)日：2006-10-10
申请号：US09967624
申请日：2001-09-28
申请人： X. Charlene Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
发明人： X. Charlene Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
CPC分类号： C12N9/1205 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/56972
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译： 本发明涉及淋巴细胞活化的调节。 更具体地，本发明涉及编码PAK2的核酸，其涉及淋巴细胞活化的调节。 本发明还涉及用于鉴定和使用通过调节PAK2调节淋巴细胞活化的试剂，包括小有机分子，肽，环肽，抗体，脂质，反义核酸和核酶的方法; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。
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公开(公告)号：US4909970A
公开(公告)日：1990-03-20
申请号：US298342
申请日：1989-01-17
申请人： Jorge Pardo
发明人： Jorge Pardo
摘要： Methods for biaxially (or triaxially) casting concrete masonry ("CM") products like CM blocks which have twin cavities formed by a pair of face shells and three webs interconnecting same with the twin cavities extending in the direction of the axis of casting of the CM block include using in the mold cavity one or more main mold cores which incorporate structure for extending and retracting a plunger or the like to provide one or more temporary mold cores laterally extending into the mold cavity from one or more main mold cores along a second axis which is normal to the axis of casting during certain selected phases of the CM casting process so as to form openings extending through one or more webs in the direction of the second axis.
摘要翻译： 双轴（或三轴）铸造混凝土砌体（“CM”）产品的方法，如具有由一对面罩形成的双腔的CM块，以及与沿着铸造轴线的轴线方向延伸的双腔相连的三个腹板 CM块包括在模腔中使用一个或多个主模芯，其包括用于延伸和缩回柱塞等的结构，以提供从一个或多个主模芯沿着第二个侧向延伸到模腔中的一个或多个临时模芯 轴，其在CM铸造工艺的某些选定阶段期间垂直于铸造轴线，以便形成沿着第二轴线的方向延伸穿过一个或多个腹板的开口。
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公开(公告)号：US4909717A
公开(公告)日：1990-03-20
申请号：US336548
申请日：1989-04-10
申请人： Jorge Pardo
发明人： Jorge Pardo
摘要： The biaxial CM casting apparatus utilizes one or more main mold cores having an automatically extensible and retractable plunger or like structure extending laterally into the mold cavity from the one or more main mold cores along an axis substantially orthogonal to the axis of casting during certain selected phases of the CM casting process to form one or more openings or other structural changes in the casted concrete which openings or changes extend in the direction of a second axis normal to the casting axis.
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公开(公告)号：US5108282A
公开(公告)日：1992-04-28
申请号：US495973
申请日：1990-03-20
申请人： Jorge Pardo
发明人： Jorge Pardo
CPC分类号： B28B7/183 , B28B7/303 , E04B2/42 , Y10S425/812
摘要： A CM block machine for casting masonry blocks includes a mold cavity formed between a mold box and a mold core containing one or more plungers selectively extending laterally into the cavity along a second axis which is normal to the axis of casting so as to form openings extending through portions of the block in the direction of the second axis. The plunger(s) is disposed in a cartridge housing contained within the mold core. An oversized vibrating ring wiper mounted in the cartridge housing engages the external periphery of the plunger to prevent CM material from entering the cartridge during plunger retraction. The plunger includes an annular relief chamber formed in a side wall thereof to provide an additional volume of air from within the cartridge to an air passage communicating with the plunger end face to prevent vacuum from impeding plunger retraction. A circular air filter is disposed in the annular chamber to prevent dirt and CM material from entering the cartridge interior through the air passage and annular chamber. The plunger width is preferably less than its length to ensure the CM material poured into the mold cavity occupies portions of the cavity located beneath the plunger. A hollow core bar supporting the mold core within the mold box protectively houses air tubings extending to the mold core to supply compressed air for selective plunger movement.
摘要翻译： 用于铸造砖石块的CM块式机器包括形成在模具箱和模芯之间的模具腔，模腔和模芯包含一个或多个柱塞，其沿着垂直于铸件轴线的第二轴线侧向选择性地延伸到腔体中，以形成开口延伸 通过该块的第二轴方向的一部分。 柱塞被设置在容纳在模芯内的盒壳体中。 安装在盒壳体中的超大型振动环刮刀与柱塞的外周接合，以防止在材料柱塞缩回期间CM材料进入料筒。 柱塞包括形成在其侧壁中的环形释放室，以从筒内提供额外体积的空气，与空气通道连通，该空气通道与柱塞端面连通，以防止真空阻碍柱塞缩回。 环形空气过滤器设置在环形室中，以防止灰尘和CM材料通过空气通道和环形室进入盒内部。 柱塞宽度优选小于其长度，以确保注入模腔的CM材料占据位于柱塞下方的腔的部分。 在模具箱内支撑模芯的中空芯棒保护性地容纳延伸到模芯的空气管，以供选择性柱塞运动的压缩空气。
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公开(公告)号：US5108281A
公开(公告)日：1992-04-28
申请号：US495972
申请日：1990-03-20
申请人： Jorge Pardo
发明人： Jorge Pardo
摘要： The biaxial CM casting apparatus utilizes one or more main mold cores having an automatically extensible and retractable plunger or like structure extending laterally into the mold cavity from the one or more main mold cores along an axis substantially orthogonal to the axis of casting during certain selected phases of the CM casting process to form one or more openings or other structural changes in the casted concrete which openings or changes extend in the direction of a second axis normal to the casting axis.
摘要翻译： 双轴CM铸造装置利用一个或多个主模具芯，其具有自动伸缩的柱塞或类似结构，其在一些选定阶段沿着基本上垂直于铸造轴线的轴线从一个或多个主模芯侧向延伸到模腔中 的CM铸造工艺以在铸造混凝土中形成一个或多个开口或其它结构变化，其中开口或变化沿着与铸造轴线垂直的第二轴线的方向延伸。
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公开(公告)号：US4977730A
公开(公告)日：1990-12-18
申请号：US403357
申请日：1989-09-06
申请人： Jorge Pardo
发明人： Jorge Pardo
摘要： A roof paver element includes a plurality of ribs projecting from a planar body portion, the ribs terminating in bottom surfaces having rounded longitudinal boundaries. The ribs are connected to the planar body portion and to one another by fillets. Sides of the planar body portions include depressions which form pressure equalization chambers with the sides of the body portions of adjacent roof paver elements in a roof system to hinder the development of air pressure differentials between the region above the roof paver elements and the spaces below the planar body portions.
摘要翻译： 屋顶摊铺机元件包括从平面主体部分突出的多个肋，所述肋终止于具有圆形纵向边界的底表面中。 肋通过鱼片连接到平面主体部分和彼此连接。 平面主体部分的侧面包括形成压力平衡室的凹部，其中车顶系统中相邻屋顶摊铺机元件的主体部分的侧面阻碍屋顶摊铺机元件之上的区域和下方的空间之间的空气压力差的发展 平面主体部分。
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公开(公告)号：US4735022A
公开(公告)日：1988-04-05
申请号：US630852
申请日：1984-07-13
申请人： Jorge Pardo
发明人： Jorge Pardo
CPC分类号： E04B1/7654 , E04F17/00
摘要： Certain types of interior concrete masonry block and stud wall constructions, and blocks for making the same, so as to provide improved thermal storage properties, improved heating and cooling and other advantages are disclosed. A preferred embodiment relates to modification of conventional interior lightweight stud wall construction systems which are in wide spread use and typically comprise lumber or steel stud framing covered by wall board with or without insulation installed within the wall. In such embodiment disclosed concrete masonry blocks are used as part of the wall by mounting the blocks between the studs and wall board. The concrete masonry blocks provide thermal storage capabilities so that the walls thus constructed store heat whereby temperature swings are attenuated and heating and/or cooling cycles are spaced at longer intervals to achieve more comfortable temperature conditions with resultant energy savings also. Also, preferred configurations of such concrete masonry blocks are provided whereby electrical junction boxes, cables, etc., may be installed within the stud wall framing and wall board. The nature of the concrete masonry blocks and the method of assembly in a stud wall are such that the walls can be mechanically constructed by unskilled workers rather than by skilled expensive masonry artisans. Also, such blocks can be used to retrofit to existing walls as well as to make new walls.
摘要翻译： 公开了某些类型的内部混凝土砌块和螺柱壁结构以及用于制造相同的块，以提供改进的储热性能，改进的加热和冷却等优点。 优选实施例涉及广泛使用的常规内部轻量级螺栓壁结构系统的修改，并且通常包括由壁板覆盖的板或钢螺栓框架，所述墙板或墙壁板具有或不具有安装在壁内的绝缘体。 在这样的实施方案中，公开了将砖块安装在螺柱和墙板之间的混凝土砌块用作壁的一部分。 混凝土砌块提供蓄热能力，使得由此构造的壁储存热量，由此温度波动被衰减，并且加热和/或冷却循环以更长的间隔隔开以实现更舒适的温度条件，从而得到节省的能量。 此外，提供了这样的混凝土砌块的优选构造，由此电接线盒，电缆等可以安装在螺柱壁框架和墙板内。 混凝土砌块的性质以及在螺栓墙中组装的方法是这样的，即墙壁可以由不熟练的工人机械地构造，而不是由熟练的昂贵的砖石工匠。 此外，这种块可以用于改造现有的墙壁以及制造新的墙壁。
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公开(公告)号：US4703602A
公开(公告)日：1987-11-03
申请号：US795536
申请日：1985-11-06
申请人： Jorge Pardo
发明人： Jorge Pardo
CPC分类号： E04B2/8641 , E02D29/0241 , E04B2002/867
摘要： A forming system for construction includes thin shell concrete block elements and connecting tie members which can be assembled into forms of various shapes and sizes to receive poured concrete. The block elements are dimensioned and configured to be produced in a standard concrete block machine mold, and include alternating dovetail-shaped grooves for receiving connecting tie members and tapered grooves for breaking the vacuum between the block elements and the mold, all of the grooves being parallel to permit the blocks to be slid out of the mold. The tie members have dovetail-shaped end portions received in the dovetail grooves and a plurality of apertures which can receive a stop member to support the tie member to project a selected distance above the block elements and serve as guides for the next course of elements. The wall system is held together by a top plate bearing on the top course of block elements and anchored directly to the foundation with flexible, coilable cables. Other tie members are configured to secure the block elements to existing structures, and still others are designed to hold the block elements against earth or other fill material to define a retaining wall.
摘要翻译： 一种用于构造的成形系统包括薄壳混凝土块体和连接构件，其可以组装成各种形状和尺寸的形式以接收浇注的混凝土。 块体的尺寸和构造被制成在标准混凝土砌块机模具中制造，并且包括交替的燕尾形槽，用于接收连接连接构件和锥形槽，用于破坏块体元件和模具之间的真空，所有槽是 平行以允许块滑出模具。 连接构件具有容纳在燕尾槽中的燕尾形端部和多个孔，其可以容纳止动构件以支撑连接构件在块体元件上方突出选定距离并用作下一道路元件的导轨。 墙壁系统通过顶板轴承在顶部的块体元件上保持在一起，并通过柔性的可卷绕的电缆直接锚固在基座上。 其他连接构件被构造成将块元件固定到现有结构，并且还有一些被设计成将块元件保持抵靠地面或其他填充材料以限定挡土墙。
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