公开(公告)号：US08642552B2

公开(公告)日：2014-02-04

申请号：US12443837

申请日：2007-10-01

申请人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

发明人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

IPC分类号： A61P25/02 ,  A61K38/18 ,  C07K14/485

CPC分类号： A61K38/1808 ,  A61K9/16 ,  C07K14/485 ,  Y10S930/12

摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

摘要翻译： 本发明涉及人类药物和表皮生长因子（EGF）用于制备药物组合物的用途，所述药物组合物通过渗透到神经节和/或树干的周围而在疼痛的感觉运动神经病变中用于外周神经的形态功能恢复 以及缺血性神经炎的表现。 本发明还包括含有EGF的组合物，其可以与麻醉剂或止痛剂一起配制或包封在微球体中，以及其用于在疼痛敏感性运动型糖尿病性神经病变中的周围神经的形态功能恢复和缺血性神经炎的表现的用途。

公开(公告)号：US20100136062A1

公开(公告)日：2010-06-03

申请号：US12443837

申请日：2007-10-01

申请人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

发明人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

IPC分类号： A61K38/18 ,  C07K14/485 ,  A61K9/00 ,  A61P25/02

CPC分类号： A61K38/1808 ,  A61K9/16 ,  C07K14/485 ,  Y10S930/12

摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

摘要翻译： 本发明涉及人类药物和表皮生长因子（EGF）用于制备药物组合物的用途，所述药物组合物通过渗透到神经节和/或树干的周围而在疼痛的感觉运动神经病变中用于外周神经的形态功能恢复 以及缺血性神经炎的表现。 本发明还包括含有EGF的组合物，其可以与麻醉剂或止痛剂一起配制或包封在微球体中，以及其用于在疼痛敏感性运动型糖尿病性神经病变中的周围神经的形态功能恢复和缺血性神经炎的表现的用途。