公开(公告)号：US08642552B2

公开(公告)日：2014-02-04

申请号：US12443837

申请日：2007-10-01

申请人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

发明人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

IPC分类号： A61P25/02 ,  A61K38/18 ,  C07K14/485

CPC分类号： A61K38/1808 ,  A61K9/16 ,  C07K14/485 ,  Y10S930/12

摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

摘要翻译： 本发明涉及人类药物和表皮生长因子（EGF）用于制备药物组合物的用途，所述药物组合物通过渗透到神经节和/或树干的周围而在疼痛的感觉运动神经病变中用于外周神经的形态功能恢复 以及缺血性神经炎的表现。 本发明还包括含有EGF的组合物，其可以与麻醉剂或止痛剂一起配制或包封在微球体中，以及其用于在疼痛敏感性运动型糖尿病性神经病变中的周围神经的形态功能恢复和缺血性神经炎的表现的用途。

公开(公告)号：US20100136062A1

公开(公告)日：2010-06-03

申请号：US12443837

申请日：2007-10-01

申请人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

发明人： Jose Ignacio Fernandez Montequin ,  Luis Saturnino Herrera Martinez ,  Jorge Amador Berlanga Acosta ,  Diana Garcia Del Barco Herrera ,  Danay Cibrian Vera ,  Gerardo Enrique Guillen Nieto ,  Raimundo Ubieta Gomez ,  Sonia Gonzalez Blanco ,  Vivian Maria Saez Martinez

IPC分类号： A61K38/18 ,  C07K14/485 ,  A61K9/00 ,  A61P25/02

CPC分类号： A61K38/1808 ,  A61K9/16 ,  C07K14/485 ,  Y10S930/12

摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

摘要翻译： 本发明涉及人类药物和表皮生长因子（EGF）用于制备药物组合物的用途，所述药物组合物通过渗透到神经节和/或树干的周围而在疼痛的感觉运动神经病变中用于外周神经的形态功能恢复 以及缺血性神经炎的表现。 本发明还包括含有EGF的组合物，其可以与麻醉剂或止痛剂一起配制或包封在微球体中，以及其用于在疼痛敏感性运动型糖尿病性神经病变中的周围神经的形态功能恢复和缺血性神经炎的表现的用途。

公开(公告)号：US20100093616A1

公开(公告)日：2010-04-15

申请号：US11885330

申请日：2006-02-24

申请人： Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  Jorge Amador Berlanga Acosta ,  Freya de los Milagros Freyre Almeida ,  Danay Cibrian Vera ,  Eduardo Pentón Arias

发明人： Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  Jorge Amador Berlanga Acosta ,  Freya de los Milagros Freyre Almeida ,  Danay Cibrian Vera ,  Eduardo Pentón Arias

IPC分类号： A61K38/18

CPC分类号： A61K38/08 ,  A61K38/1808 ,  A61K38/25 ,  A61K2300/00

摘要： The present invention is directed to stimulate the neuroregeneration of the central nervous system due to autoimmune damage. In particular the pharmaceutical combination that comprise therapeutically effective concentrations of the Epidermal Growth Factor and the Growth Hormone Releasing Peptide-6, is administrated to a subject that suffers from symptoms of Multiple Sclerosis and Optic Neuromyelitis and corrects the demyelination caused by autoreactive cells in central nervous system.

摘要翻译： 本发明旨在刺激由于自身免疫损伤引起的中枢神经系统的神经再生。 特别地，包含治疗有效浓度的表皮生长因子和生长激素释放肽-6的药物组合被施用于患有多发性硬化症和视神经脊髓炎症状的受试者，并且校正由中枢神经中的自身反应性细胞引起的脱髓鞘 系统。

公开(公告)号：US20090221512A1

公开(公告)日：2009-09-03

申请号：US12281018

申请日：2007-02-23

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillen Nieto ,  Jose Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillen Nieto ,  Jose Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61K38/08

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。

公开(公告)号：US08722626B2

公开(公告)日：2014-05-13

申请号：US13150526

申请日：2011-06-01

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61P19/04 ,  A61K38/08 ,  C07K7/06

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。

公开(公告)号：US20110230415A1

公开(公告)日：2011-09-22

申请号：US13150526

申请日：2011-06-01

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61K38/08 ,  A61P17/00 ,  A61P1/16 ,  A61P13/12 ,  A61P25/00 ,  A61P27/16 ,  A61P27/02

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。