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1.发明授权
公开(公告)号：US4973579A
公开(公告)日：1990-11-27
申请号：US311557
申请日：1989-02-16
Applicant: Jose Alexander , Joseph A. Fix
Inventor： Jose Alexander , Joseph A. Fix
CPC classification number: A61K9/0031 , A61K47/186 , A61K9/0053 , Y10S514/946
Abstract: Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.
Abstract translation: 胆碱酯盐用作口服和直肠给药药物吸收增强剂。
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2.发明授权Choline esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities 失效胆碱酯作为吸收增强剂，用于通过鼻，颊，舌下和阴道腔的粘膜药物递送
公开(公告)号：US4963556A
公开(公告)日：1990-10-16
申请号：US340840
申请日：1989-04-20
Applicant: Jose Alexander , Joseph A. Fix , A. J. Repta
Inventor： Jose Alexander , Joseph A. Fix , A. J. Repta
IPC: A61K47/18
CPC classification number: A61K47/186 , Y10S514/946 , Y10S514/947
Abstract: Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
Abstract translation: 胆碱酯用作药物吸收增强剂，用于从鼻腔，口腔和阴道腔吸收不良的药物。
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3.发明授权Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments 失效酰基肉碱作为吸收增强剂，用于通过鼻，颊，舌下和阴道隔室的粘膜药物递送
公开(公告)号：US4847298A
公开(公告)日：1989-07-11
申请号：US130919
申请日：1987-12-10
Applicant: Jose Alexander , Joseph A. Fix , A. J. Repta
Inventor： Jose Alexander , Joseph A. Fix , A. J. Repta
CPC classification number: A61K47/186 , A61K9/0034 , A61K9/0043 , A61K9/006 , Y10S514/946 , Y10S514/947
Abstract: Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.
Abstract translation: 酰基肉碱用作吸收不良药物的鼻，颊，舌下和阴道药物吸收增强载体。
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4.发明授权
公开(公告)号：US4822773A
公开(公告)日：1989-04-18
申请号：US130916
申请日：1987-12-20
Applicant: Jose Alexander , Joseph A. Fix
Inventor： Jose Alexander , Joseph A. Fix
IPC: A61K9/00 , A61K47/18 , A61K37/26 , A61K31/195 , A61K37/00
CPC classification number: A61K47/186 , A61K9/0031 , A61K9/0053 , Y10S514/946 , Y10S514/947 , Y10S930/27
Abstract: Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.
Abstract translation: 胆碱酯盐用作口服和直肠给药药物吸收增强剂。
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公开(公告)号：US4731360A
公开(公告)日：1988-03-15
申请号：US766378
申请日：1985-08-16
Applicant: Jose Alexander , A. J. Repta , Joseph A. Fix
Inventor： Jose Alexander , A. J. Repta , Joseph A. Fix
IPC: A61K47/16 , A61K9/00 , A61K47/18 , A61K31/43 , A61K31/545
CPC classification number: A61K47/186 , A61K9/0034 , A61K9/0043 , A61K9/006 , Y10S514/946
Abstract: Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.
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Patent Agency Ranking6.发明授权
公开(公告)号：US4729989A
公开(公告)日：1988-03-08
申请号：US749696
申请日：1985-06-28
Applicant: Jose Alexander , Joseph A. Fix
Inventor： Jose Alexander , Joseph A. Fix
CPC classification number: A61K47/186 , A61K9/0031 , A61K9/0053 , Y10S514/946 , Y10S514/947 , Y10S930/27
Abstract: Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.
Abstract translation: 胆碱酯盐用作口服和直肠给药药物吸收增强剂。
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7.发明授权Tablets and methods for modified release of hydrophilic and other active agents 有权用于改性释放亲水性和其他活性剂的片剂和方法公开(公告)号：US06419954B1
公开(公告)日：2002-07-16
申请号：US09599102
申请日：2000-05-19
Applicant: James S. Chu , Yisong Yang , Joseph A. Fix
Inventor： James S. Chu , Yisong Yang , Joseph A. Fix
IPC: A61K920
CPC classification number: A61K9/2077 , A61K9/2031 , A61K9/2081 , A61K9/2086 , A61K9/209
Abstract: The invention provides a tablet and methods for making the tablet comprising a gel-forming material and at least one particle comprising an active agent in contact with a coating material to modify release of the active agent.
Abstract translation: 本发明提供了一种片剂和制备片剂的方法，所述片剂包含凝胶形成材料和至少一种包含与涂层材料接触的活性剂的颗粒，以改变活性剂的释放。
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8.发明授权Tablets incorporating isoflavone plant extracts and methods of manufacturing them 有权含有异黄酮植物提取物的片剂及其制造方法公开(公告)号：US06413546B1
公开(公告)日：2002-07-02
申请号：US09273237
申请日：1999-03-18
Applicant: Min Michael He , Fang-Yu Liu , Joseph A. Fix , Martin Link , Maria L. Kang , Ezio Bombardelli
Inventor： Min Michael He , Fang-Yu Liu , Joseph A. Fix , Martin Link , Maria L. Kang , Ezio Bombardelli
IPC: A61K920
CPC classification number: A61K9/205 , A61K9/2866
Abstract: The invention is directed to novel tablets comprising isoflavone-containing plant extract and water-insoluble polysaccharides, and methods of manufacturing them.
Abstract translation: 本发明涉及包含含异黄酮的植物提取物和水不溶性多糖的新型片剂及其制造方法。
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9.发明授权Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments 失效酰基肉碱作为吸收增强剂，用于通过鼻，颊，舌下和阴道隔室的粘膜药物递送
公开(公告)号：US4963525A
公开(公告)日：1990-10-16
申请号：US353739
申请日：1989-05-16
Applicant: Jose Alexander , Joseph A. Fix , A. J. Repta
Inventor： Jose Alexander , Joseph A. Fix , A. J. Repta
IPC: A61K47/18
CPC classification number: A61K47/186 , Y10S514/946 , Y10S514/947
Abstract: Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.
Abstract translation: 酰基肉碱用作吸收不良药物的鼻，颊，舌下和阴道药物吸收增强载体。
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10.发明授权Choline esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities 失效胆碱酯作为吸收增强剂，用于通过鼻，颊，舌下和阴道腔的粘膜药物递送
公开(公告)号：US4835138A
公开(公告)日：1989-05-30
申请号：US50643
申请日：1987-05-18
Applicant: Jose Alexander , A. J. Repta , Joseph A. Fix
Inventor： Jose Alexander , A. J. Repta , Joseph A. Fix
CPC classification number: A61K47/186 , A61K9/0034 , A61K9/0043 , A61K9/006 , Y10S514/946 , Y10S514/947 , Y10S930/27
Abstract: Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
Abstract translation: 胆碱酯用作药物吸收增强剂，用于从鼻腔，口腔和阴道腔吸收不良的药物。
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