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公开(公告)号：US5645559A
公开(公告)日：1997-07-08
申请号：US172516
申请日：1993-12-21
申请人： Steven W. Hachtman , Liann M. Johnson , Scott T. Johnson , Joseph E. Laptewicz, Jr. , Paul J. Thompson , Amjad Ahmad , John A. Scholl , Richard J. Thompson
发明人： Steven W. Hachtman , Liann M. Johnson , Scott T. Johnson , Joseph E. Laptewicz, Jr. , Paul J. Thompson , Amjad Ahmad , John A. Scholl , Richard J. Thompson
CPC分类号： A61F2/90 , A61F2/07 , A61F2/95 , A61F2/966 , A61F2/0077 , A61F2/852 , A61F2002/072 , A61F2002/821 , A61F2002/9517 , A61F2002/9534 , A61F2002/9665 , A61F2210/0076 , A61F2220/0033 , A61F2220/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0063 , A61F2250/0097 , A61M2025/0008 , A61M25/1018
摘要： A radially self-expanding stent having multiple layers includes a medial region and proximal and distal cuffs having diameters greater than the medial region diameter when the stent is in the relaxed state. A silicone coating circumscribes at least the medial region of the stent. A deployment device for the stent includes an inner tube surrounded by the stent along with an outer tube that radially compresses the stent. A low durometer sleeve, fixed to the inner tube and in surface engagement with the compressed stent, tends to fix the axial position of the stent relative to the inner tube whenever the outer tube is moved axially relative to the inner tube. Consequently, precision in stent placement and the ability to recapture a partially deployed stent are enhanced.
摘要翻译： 具有多层的径向自扩张支架包括中间区域和当支架处于松弛状态时具有大于中间区域直径的直径的近端和远端箍。 硅胶涂层至少包围支架的内侧区域。 用于支架的展开装置包括由支架围绕的内管以及径向压缩支架的外管。 每当外管相对于内管轴向移动时，固定到内管并与压缩支架表面接合的低硬度套筒倾向于固定支架相对于内管的轴向位置。 因此，增强了支架放置的精度和再次部分展开支架的能力。
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2.发明授权
公开(公告)号：US4061585A
公开(公告)日：1977-12-06
申请号：US746595
申请日：1976-12-01
CPC分类号： C11D3/222 , C08B37/00 , C11D3/0036 , C12P19/04 , D06M15/03 , Y10T137/0391
摘要： Disclosed is a new heteropolysaccharide polymer and a method for producing this polymer by a fermentation process comprising culturing a heteropolysaccharide-producing strain of a micro-organism of the genus Methylomonas on an aqueous culture medium containing methanol as the sole source of assimilable carbon. Several uses for the heteropolysaccharide are also disclosed such as its use as a drag reducing agent, a thickening agent, an emulsifier, a soil suspending agent and a flocculant or deflocculant.
摘要翻译： 公开了一种新的杂多糖聚合物和通过发酵方法生产该聚合物的方法，包括在含有甲醇作为唯一可同化碳源的含水培养基上培养产生Methylomonas属微生物的杂多糖的菌株。 还公开了多种用于杂多糖的用途，例如其用作减阻剂，增稠剂，乳化剂，污垢悬浮剂和絮凝剂或抗絮凝剂。
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公开(公告)号：US4834755A
公开(公告)日：1989-05-30
申请号：US707724
申请日：1985-03-04
CPC分类号： A61F2/2412 , A61F2/06 , A61F2/08
摘要： A novel prosthesis for use in repairing or replacing soft tissue is disclosed, which comprises a triaxially-braided fabric element having interwoven first, second and third sets of fibers, with the fibers of the second and third sets being oriented at substantially the same acute braiding angle with respect to the fibers of the first set. An elongated ligament prosthesis exhibiting the desired properties of high strength and high elasticity may be prepared by selecting high elasticity fibers for the first set, orienting said first set of fibers in the longitudinal direction of the prosthesis and selecting fibers having high yield strength and high Young's modulus for the second and third sets. A tubular prosthesis in which high elasticity fibers are oriented in the longitudinal direction is highly suitable for use as a vascular prosthesis. A prosthesis of the invention may also be manufactured in the form of a prosthetic heart valve leaflet.
摘要翻译： 公开了一种用于修复或更换软组织的新型假体，其包括具有交织的第一，第二和第三组纤维的三轴编织织物元件，第二和第三组的纤维被定向成基本上相同的尖锐编织 相对于第一组的纤维的角度。 可以通过选择第一组的高弹性纤维，在假体的纵向方向上定向所述第一组纤维并选择具有高屈服强度的纤维和高杨氏硬度的纤维来制备具有高强度和高弹性所需性质的细长韧带假体 第二和第三组的模数。 其中高弹性纤维沿纵向定向的管状假体非常适合用作血管假体。 本发明的假体也可以以假体心脏瓣膜小叶的形式制造。
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公开(公告)号：US4611588A
公开(公告)日：1986-09-16
申请号：US741336
申请日：1985-06-05
IPC分类号： C08K3/04 , A61B18/20 , A61B19/00 , A61L31/12 , A61M16/04 , C08K3/02 , C08L83/00 , C08L83/02 , C08L101/00 , A61F13/00
CPC分类号： A61M16/0422 , A61B90/04 , A61L31/126 , A61M16/04 , A61B2090/049
摘要： A shielding material for use in such as endotracheal tubes during laser beam surgery comprising a dispersion of particulate graphite in a polymer matrix.
摘要翻译： 在激光束手术期间用于诸如气管内导管的屏蔽材料包括颗粒状石墨在聚合物基质中的分散体。
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公开(公告)号：US5071040A
公开(公告)日：1991-12-10
申请号：US491754
申请日：1990-03-09
CPC分类号： A61B17/8822 , A61B17/00491 , B01F13/002 , B01F15/00681 , A61B2017/00685 , A61B2017/8838 , A61F2002/30289 , A61F2230/0091 , B01F2215/0029 , B01F2215/0039 , B01F7/00416
摘要： An apparatus for mixing and dispensing a surgical adhesive having at least two components has a barrel with a central longitudinal axis extending from a first to a second end thereof. The second end includes a nozzle with a discharge port. A rotatable screw conveyor shaft extends through the barrel position along the longitudinal axis. A dispensing element is mounted within the barrel and has a threaded bore for operative engagement with the screw shaft. The dispensing element has a keyway and may freely rotate at the first end of the barrel. A snap element is included to move the dispensing element into engagement with a key on the inner surface of the barrel which prevents the rotation of the dispensing element and causes the dispensing element to move from the first end of the barrel to the second end dispensing the adhesive.
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公开(公告)号：US4610688A
公开(公告)日：1986-09-09
申请号：US481612
申请日：1983-04-04
CPC分类号： A61F2/08 , A61F2/06 , A61F2/2412 , D04C1/06 , D07B1/02 , D07B2201/1096 , D10B2403/02411 , D10B2509/00 , D10B2509/06
摘要： A novel prosthesis for use in repairing or replacing soft tissue is disclosed, which comprises a triaxially-braided fabric element having interwoven first, second and third sets of fibers, with the fibers of the second and third sets being oriented at substantially the same acute braiding angle with respect to the fibers of the first set. An elongated ligament prosthesis exhibiting the desired properties of high strength and high elasticity may be prepared by selecting high elasticity fibers for the first set, orienting said first set of fibers in the longitudinal direction of the prosthesis and selecting fibers having high yield strength and high Young's modulus for the second and third sets. A tubular prosthesis in which high elasticity fibers are oriented in the longitudinal direction is highly suitable for use as a vascular prosthesis. A prosthesis of the invention may also be manufactured in the form of a prosthetic heart valve leaflet.
摘要翻译： 公开了一种用于修复或更换软组织的新型假体，其包括具有交织的第一，第二和第三组纤维的三轴编织织物元件，第二和第三组的纤维被定向在基本上相同的急性编织 相对于第一组的纤维的角度。 可以通过选择第一组的高弹性纤维，在假体的纵向方向上定向所述第一组纤维并选择具有高屈服强度的纤维和高杨氏硬度的纤维来制备具有高强度和高弹性所需性质的细长韧带假体 第二和第三组的模数。 其中高弹性纤维沿纵向定向的管状假体非常适合用作血管假体。 本发明的假体也可以以假体心脏瓣膜小叶的形式制造。
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公开(公告)号：US4016085A
公开(公告)日：1977-04-05
申请号：US592603
申请日：1975-07-02
CPC分类号： C12R1/26 , C08B37/00 , C12P19/04 , Y10S507/936
摘要： Disclosed is a new heteropolysaccharide polymer and a method for producing this polymer by a fermentation process comprising culturing a heteropolysaccharide-producing strain of a micro-organism of the genus Methylomonas on an aqueous culture medium containing methanol as the sole source of assimilable carbon. Several uses for the heteropolysaccharide are also disclosed such as its use as a drag reducing agent, a thickening agent, an emulsifier, a soil suspending agent and a flocculant or deflocculant.
摘要翻译： 公开了一种新的杂多糖聚合物和通过发酵方法生产该聚合物的方法，包括在含有甲醇作为唯一可同化碳源的含水培养基上培养产生Methylomonas属微生物的杂多糖的菌株。 还公开了多种用于杂多糖的用途，例如其用作减阻剂，增稠剂，乳化剂，污垢悬浮剂和絮凝剂或抗絮凝剂。
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公开(公告)号：US5984957A
公开(公告)日：1999-11-16
申请号：US79806
申请日：1998-05-15
CPC分类号： A61F2/86 , A61F2/88 , A61F2/90 , A61F2/95 , A61F2002/9511 , A61F2250/0018
摘要： A tubular, radially self-expanding stent includes a latticework of interbraided, helically wound resilient structural strands. An axial control member is secured to the tubular latticework at axially spaced apart proximal and distal coupling locations. At the proximal location, the control member is coupled slidably, to permit an adjustment of the axial distance between the coupling locations, thus to selectively adjust the radius profile of the latticework between the two locations. To set a desired radius profile, the control member either is crimped near the proximal location or fixed within a self-locking connector. The control members, preferably monofilament strands, can be elastic or substantially inextensible. Two or more control members can be used if desired. In an alternative embodiment, recovery metal control members are fixed at their opposite ends to the latticework, then plastically deformed by elongation to axially elongate and radially reduce the latticework. Following deployment, the control members are heated sufficiently to cause the control members to return to their shorter, nominal shapes, to axially shorten and radially enlarge the stent. Both versions preferably feature selvaged ends.
摘要翻译： 管状的径向自扩张支架包括插入的，螺旋缠绕的弹性结构股线的网格。 轴向控制构件在轴向间隔开的近端和远端联接位置处固定到管状网格。 在近侧位置处，控制构件可滑动地联接，以允许调整联接位置之间的轴向距离，从而选择性地调整两个位置之间的网格的半径分布。 为了设置所需的半径轮廓，控制构件或者在近端位置附近被压接或固定在自锁连接器内。 控制构件，优选单丝股线可以是弹性的或基本不可伸长的。 如果需要，可以使用两个或多个控制构件。 在替代实施例中，回收金属控制构件在其相对端固定在网格上，然后通过伸长而被塑性变形以轴向延伸并径向减小网格。 在展开之后，控制构件被充分加热以使控制构件返回到其更短的标称形状，从而轴向缩短和径向扩大支架。 两种版本优选地具有边缘化。
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公开(公告)号：US5876448A
公开(公告)日：1999-03-02
申请号：US614917
申请日：1996-03-13
CPC分类号： A61F2/90 , A61F2/07 , A61F2/95 , A61F2/966 , A61F2/0077 , A61F2/852 , A61F2002/072 , A61F2002/821 , A61F2002/9517 , A61F2002/9534 , A61F2002/9665 , A61F2210/0076 , A61F2220/0033 , A61F2220/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0063 , A61F2250/0097 , A61M2025/0008 , A61M25/1018
摘要： A radially self-expanding stent particularly suited for treating esophageal strictures, includes a medial region and proximal and distal cuffs having diameters greater than the medial region diameter when the stent is in the relaxed state. A silicone coating circumscribes the medial region, but the cuffs are not coated and retain their open weave construction. As a result, the cuffs remain particularly well suited to immediately contact esophageal wall tissue and resist stent migration, while the silicone coated medial region provides a barrier to tumor ingrowth, and has an enhanced radial restoring force to maintain an open passageway in the esophagus. A deployment device for the stent includes an interior catheter surrounded by the stent and having an esophageal dilation feature, along with an exterior catheter that radially compresses the stent. A low durometer sleeve, fixed to the interior tube and in surface engagement with the compressed stent, tends to fix the axial position of the stent relative to the interior catheter whenever the exterior catheter is moved axially relative to the inner catheter. Consequently, precision in stent placement and the ability to recapture a partially deployed stent are enhanced.
摘要翻译： 特别适用于治疗食道狭窄的径向自扩张支架包括当支架处于松弛状态时具有大于中间区域直径的直径的中间区域和近端和远端箍。 硅胶涂层限制了内侧区域，但是袖口没有被涂覆并保持开放的编织结构。 结果，袖口保持特别适合于立即接触食管壁组织并抵抗支架移动，而硅氧烷涂覆的内侧区域为肿瘤向内生长提供了屏障，并且具有增强的径向恢复力以保持食道中的开放通道。 用于支架的展开装置包括由支架围绕并具有食管扩张特征的内部导管以及径向压缩支架的外部导管。 固定在内管上并与压缩的支架表面接合的低硬度套筒，每当外导管相对于内导管轴向移动时，倾向于固定支架相对于内导管的轴向位置。 因此，增强了支架放置的精度和再次部分展开支架的能力。
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公开(公告)号：US5653684A
公开(公告)日：1997-08-05
申请号：US452637
申请日：1995-05-25
CPC分类号： A61F2/90 , A61B18/1492 , A61M29/02 , A61B2017/00504 , A61B2018/00214 , A61B2018/00422 , A61F2002/9511 , A61F2220/0008
摘要： A catheter for use in angioplasty and other medical procedures is disclosed. The catheter features a flexible-wire mesh tip movably attached at a distal end of the catheter, the tip being expandable from a contracted position which it is first in when the catheter is deployed inside the lumen of a vessel, to stretch open the lumen and eliminate a flow obstruction therein, such as is caused by plaque deposits; the tip subsequently being returnable to its contracted position inside the catheter when the catheter is withdrawn from the lumen of the vessel. Radio frequency energy may additionally be used to weld the source of the flow obstruction to the wall of the lumen leaving a conduit of sufficiently expanded diameter to allow resumption of normal flow in the vessel.
摘要翻译： 公开了用于血管成形术和其他医疗程序的导管。 导管具有可移动地附接在导管的远端处的柔性丝网，尖端可从收缩位置扩展，当收缩位置首先在导管部署在血管腔内时，拉伸开口腔， 消除其中的流动阻塞，如由斑块沉积造成的; 当导管从容器的内腔中取出时，尖端随后可返回到导管内的收缩位置。 另外可以使用射频能量将流动阻塞的源焊接到管腔的壁，留下具有足够扩张的直径的导管，以允许在容器中恢复正常的流动。
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