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1.发明授权Force measurement and analysis particularly relating to rotary tablet presses 失效特别是与旋转式压片机相关的力测量和分析
公开(公告)号：US4030868A
公开(公告)日：1977-06-21
申请号：US666734
申请日：1976-03-15
CPC分类号： B30B11/005
摘要： There is disclosed instrumentation for use in connection with one or more tablet presses of various types, and in particular rotary tablet presses, for virtually any reasonable combination and number of such tablet presses. Tablet formation information, in particular compression and ejection force information, tablet capping information and force information related to the time of occurrence of punch withdrawal is provided and processed by such instrumentation. This information is selectively applied to converting means which renders the selected information in a convenient data form for processing. Selection of the information may be made for example based on the need or desire to monitor a particular tablet press, tablet press station and/or individual tablet die/punch set combination. The selected information is processed by data processing means to provide output signals, including tablet press control signals, relating for example to the average and standard deviation of a pre-established number of consecutive tabletting events and determination of the frequency and number of abnormal tablet formations. The instrumentation may be employed to determine tabletting characteristics of pharmaceutical tablet granulations. Provision is also made for determining and isolating tablets failing to meet pre-established criteria.
摘要翻译： 公开了用于与一种或多种各种类型的压片机一起使用的仪器，特别是旋转式压片机，用于实际上任何合理的组合和数量的这种压片机。 通过这种仪器提供并处理片剂形成信息，特别是压缩和排出力信息，片剂封盖信息和与拔出发生时间相关的力信息。 该信息被选择性地应用于转换装置，其使所选择的信息以便利的数据形式进行处理。 可以例如基于对特定压片机，压片机和/或单独的片剂模具/冲头组合的监视的需要或期望来进行信息的选择。 所选择的信息由数据处理装置处理，以提供输出信号，包括压片机控制信号，例如与预先建立的连续压片事件数量的平均和标准偏差相关联，以及确定异常图形输入板的频率和数量 。 该仪器可用于确定药物片剂颗粒的压片特性。 还规定了确定和隔离不符合预先确定标准的药片。
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公开(公告)号：US4016744A
公开(公告)日：1977-04-12
申请号：US658209
申请日：1976-02-17
CPC分类号： B30B11/005 , A61J3/10
摘要： There is disclosed a method and apparatus for standardizing, in terms of a pre-established range of acceptable in vitro release and/or in vivo response, production of tabletted formulations which have a dependency on tablet hardness, through control of the maximum tabletting compression force developed by the tablet press employed, and for providing an individual momentary as well as permanent readout in digital form of the maximum compression force developed for each tabletting event. One or more tablets are compressed from a particular batch of formulation at selected different press compression force settings. These tablets are processed to derive data regarding in vitro release and/or in vivo response with a determination of an optimum value being made directly from or by interpolation of the resulting data. This optimum value is correlated to a press setting and the press is then set thereat for the tabletting of the bulk of the batch of formulation. Transducer means are appropriately mounted on the press to effect a signal output indicative of the compression force developed for each tabletting event. The transducer output is processed to derive only the true maximum developed compression force for each tabletting event. The derived force is then displayed and recorded in digital form.
摘要翻译： 公开了一种方法和装置，用于通过控制最大压片压力来标准化可接受的体外释放和/或体内响应的预先确定的范围，以制备依赖于片剂硬度的压片制剂 由采用的压片机开发，并为每个压片事件开发的最大压缩力的数字形式提供个人瞬时和永久读数。 一个或多个片剂在选定的不同的压制压力设置下从特定批次的制剂中压缩。 处理这些片剂以得到关于体外释放和/或体内反应的数据，通过直接从所得数据的内插或通过内插得到的最佳值的确定。 该最佳值与压机设定相关，然后将压力机设置在该压片机上用于批量批量制剂的压片。 传感器装置适当地安装在压机上以实现指示针对每个压片事件产生的压缩力的信号输出。 传感器输出被处理以仅导出每个压片事件的真实最大显影压缩力。 然后以数字形式显示和记录导出的力。
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3.发明授权
公开(公告)号：US4100598A
公开(公告)日：1978-07-11
申请号：US714141
申请日：1976-08-13
CPC分类号： G07C3/14 , B30B11/005
摘要： There is disclosed a method and apparatus for developing and controlling pharmaceutical granulations from a tabletting characteristics standpoint, involving instrumenting a tablet press to derive both the peak compression force and peak ejection force information for each tabletting event in convenient digital form. The thusly derived compression and ejection force information is automatically scaled to desired units of force and utilized in compression and ejection profiles and in the calculation of the average and standard deviations for both compression and ejection in the pursuit of optimization of the tabletted granulation regarding such tabletting characteristics as compressibility, lubricity, relative flow, compression failure point, and tendency of the formed tablets to adhere to the tablet press punches. In addition to the capability of distinguishing between the large-magnitude compression peaks and the relatively very small-magnitude ejection force peaks in the raw analog signal generated from a force transducer mounted on the tablet press, there is provided the capability of measuring ejection force peaks relative to a plurality of selectable reference levels, which enables the granulation formulator to take into account the residual force aspects found to exist following compression and prior to ejection of a formed tablet.
摘要翻译： 公开了一种用于从压片特性观点开发和控制药物颗粒的方法和装置，其包括测量压片机，以方便数字形式得出每个压片事件的峰值压缩力和峰值排出力信息。 这样得到的压缩和排出力信息被自动缩放到所需的力单位，并用于压缩和喷射曲线，并且在计算压缩和喷射的平均和标准偏差时，追求关于这种压片的压片造粒的优化 特性作为压缩性，润滑性，相对流动性，压缩破坏点和形成的片剂粘附到压片冲压机的趋势。 除了区分大幅度压缩峰值和从安装在压片机上的力传感器产生的原始模拟信号中相对非常小幅度的喷射力峰值的能力之外，还提供了测量喷射力峰值的能力 相对于多个可选择的参考水平，这使得造粒配方设计师能够考虑压缩后和排出成形片剂之前存在的残余力方面。
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4.发明授权Force measurement and analysis particularly relating to rotary tablet presses 失效特别是与旋转式压片机相关的力测量和分析
公开(公告)号：US4099239A
公开(公告)日：1978-07-04
申请号：US761844
申请日：1977-01-24
CPC分类号： B30B11/005
摘要： There is disclosed instrumentation for use in connection with one or more tablet presses of various types, and in particular rotary tablet presses, for virtually any reasonable combination and number of such tablet presses. Tablet formation information, in particular compression and ejection force information, tablet capping information and information related to punch withdrawal is provided and processed by such instrumentation. This information is selectively applied to converting means which renders the selected information in a convenient data form for processing. Selection of the information may be made for example based on the need or desire to monitor a particular tablet press, tablet press station and/or individual tablet die/punch set combination. The selected information is processed by data processing means to provide output signals, including tablet press control signals, relating for example to the average and standard deviation of a pre-established number of consecutive tabletting events and determination of the frequency and number of abnormal tablet formations. The instrumentation may be employed to determine tabletting characteristics of pharmaceutical tablet granulations. Provision is also made for determining and isolating tablets failing to meet pre-established criteria.
摘要翻译： 公开了用于与一种或多种各种类型的压片机一起使用的仪器，特别是旋转式压片机，用于实际上任何合理的组合和数量的这种压片机。 片剂形成信息，特别是压缩和排出力信息，片剂封盖信息和与拔模相关的信息由这种仪器提供和处理。 该信息被选择性地应用于转换装置，其使所选择的信息以便利的数据形式进行处理。 可以例如基于对特定压片机，压片机和/或单独的片剂模具/冲头组合的监视的需要或期望来进行信息的选择。 所选择的信息由数据处理装置处理，以提供输出信号，包括压片机控制信号，例如与预先建立的连续压片事件数量的平均和标准偏差相关联，以及确定异常图形输入板的频率和数量 。 该仪器可用于确定药物片剂颗粒的压片特性。 还规定了确定和隔离不符合预先确定标准的药片。
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