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公开(公告)号：US08790919B2
公开(公告)日：2014-07-29
申请号：US10592919
申请日：2005-03-15
申请人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
发明人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
CPC分类号： C12N15/85 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/346 , C12N2310/3519 , C12N2310/3525
摘要： The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.
摘要翻译： 本发明提供了通过RNA酶H优化RNA种类的切割的组合物和方法。在一些实施方案中，本发明提供具有不同构象的两个或更多个区域的寡核苷酸，以及位于能够区分的区域之间的至少一个过渡核碱基 调节与其3'-羟基结合的区域的螺旋构象特征转移到与其5'羟基结合的区域。
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2.发明申请公开(公告)号：US20080207541A1
公开(公告)日：2008-08-28
申请号：US10592919
申请日：2005-03-15
申请人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
发明人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
CPC分类号： C12N15/85 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/346 , C12N2310/3519 , C12N2310/3525
摘要： The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.
摘要翻译： 本发明提供了通过RNA酶H优化RNA种类的切割的组合物和方法。在一些实施方案中，本发明提供具有不同构象的两个或更多个区域的寡核苷酸，以及位于能够区分的区域之间的至少一个过渡核碱基 调节与其3'-羟基结合的区域的螺旋构象特征转移到与其5'羟基结合的区域。
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公开(公告)号：US07138613B1
公开(公告)日：2006-11-21
申请号：US11193784
申请日：2005-07-29
IPC分类号： H05B3/06
CPC分类号： H05B3/00 , A63B37/0003 , A63B47/005
摘要： The present invention is directed to a golf ball heater comprising a rectangular container, the interior of which is outfitted with at least one heating element and rails for holding golf balls. One end of the container includes a sliding door for retrieving a heated golf ball. On one side of the container, a control box is outfitted with circuitry to cooperatively work with sensors in the container for purposes of selectively activating the heating element(s) according to whether or not the sliding door is open or shut and whether or not the temperature inside the container is within the optimal temperature range.
摘要翻译： 本发明涉及一种高尔夫球加热器，其包括矩形容器，其内部配备有至少一个加热元件和用于保持高尔夫球的轨道。 容器的一端包括用于回收加热的高尔夫球的滑动门。 在容器的一侧，控制箱配有电路，以与容器中的传感器协同工作，以便根据滑动门是否打开或关闭选择性地启动加热元件，以及是否 容器内的温度在最佳温度范围内。
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