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公开(公告)号:US07074819B2
公开(公告)日:2006-07-11
申请号:US10640696
申请日:2003-08-12
申请人: Jae Chon Jo , Hyun Suk Lim , Jong Min Kim , Ju Su Kim , Kazumi Morikawa , Yoshitake Kanbe , Myung Hwa Kim , Masahiro Nishimoto
发明人: Jae Chon Jo , Hyun Suk Lim , Jong Min Kim , Ju Su Kim , Kazumi Morikawa , Yoshitake Kanbe , Myung Hwa Kim , Masahiro Nishimoto
IPC分类号: A61K31/38 , C07D335/04
CPC分类号: C07D335/06 , C07D311/58 , C07D405/04 , C07D405/06 , C07D407/06 , C07D413/06 , C07D417/06
摘要: The present invention relates to a novel benzopyran or thiobenzopyran derivative represented by formula (1): pharmaceutically acceptable salt or stereoisomer thereof, in which X, R1, R2, R3, R4 and A are defined as described in the specification, and to a process for preparation thereof and a pharmaceutical composition having anti-estrogenic activity which contains the compound (1) as an active component.
摘要翻译: 本发明涉及由式(1)表示的新的苯并吡喃或硫代苯并吡喃衍生物:其药学上可接受的盐或立体异构体,其中X,R 1,R 2,R R 3,R 4和A如说明书中所述定义,其制备方法和具有抗雌激素活性的药物组合物含有化合物(1 )作为活性成分。
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公开(公告)号:US6153768A
公开(公告)日:2000-11-28
申请号:US319616
申请日:1999-06-08
申请人: Jae Chon Jo , Sung Dae Park , Hyun Suk Lim , Ju Su Kim , Sung Jin Kim , Kazumi Morikawa , Yoshitake Kanbe , Masahiro Nishimoto , Myung-Hwa Kim
发明人: Jae Chon Jo , Sung Dae Park , Hyun Suk Lim , Ju Su Kim , Sung Jin Kim , Kazumi Morikawa , Yoshitake Kanbe , Masahiro Nishimoto , Myung-Hwa Kim
IPC分类号: A61K31/352 , A61K31/353 , A61K31/382 , A61K31/453 , A61K31/496 , A61P5/32 , A61P15/00 , C07D311/38 , C07D311/58 , C07D335/06 , C07D311/04
CPC分类号: C07D335/06 , C07D311/38 , C07D311/58
摘要: The present invention relates to a novel benzopyran derivative having anti-estrogenic activity. More specifically, the present invention relates to a novel benzopyran derivative represented by formula (I) and pharmaceutically acceptable salt thereof, in which ----- represents a single bond or a double bond; R1 and R2 independently of one another represent hydrogen, hydroxy or OR group, wherein R represents acyl or alkyl; R3 represents hydrogen, lower alkyl or halogeno lower alkyl, provided that when ----- represents a double bond, R3 is not present; R4 represents hydrogen or lower alkyl; A represents a group of formula a, b, c or d; R5, R6 and R7 independently of one another represent hydrogen, alkyl, halogenoalkyl, alkenyl or halogenoalkenyl, or R6 and R7 together with nitrogen atom to which they are bound can form a 4- to 8-membered heterocyclic ring which can be substituted with R5; X represents O, S, or NR8, wherein R8 represents hydrogen or lower alkyl; m denotes an integer of 2 to 15; n denotes an integer of 0 to 2; and p denotes an integer of 0 to 4.
摘要翻译: PCT No.PCT / KR97 / 00265 Sec。 371 1999年6月8日第 102(e)日期1999年6月8日PCT 1997年12月13日PCT公布。 公开号WO98 / 25916 PCT 日期:1998年6月18日本发明涉及具有抗雌激素活性的新型苯并吡喃衍生物。 更具体地说,本发明涉及由式(I)表示的新型苯并吡喃衍生物及其药学上可接受的盐,其中+ E,uns ----- + EE表示单键或双键; R 1和R 2彼此独立地表示氢,羟基或OR基,其中R表示酰基或烷基; R3表示氢,低级烷基或卤代低级烷基,条件是当+ E时,不为 - + EE表示双键,R3不存在; R4代表氢或低级烷基; A表示式a,b,c或d的基团; R 5,R 6和R 7彼此独立地表示氢,烷基,卤代烷基,烯基或卤代烯基,或者R 6和R 7与它们所连接的氮原子一起可以形成可被R 5取代的4至8元杂环 ; X表示O,S或NR8,其中R8表示氢或低级烷基; m表示2〜15的整数, n表示0〜2的整数, p表示0〜4的整数。
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公开(公告)号:US20120294975A1
公开(公告)日:2012-11-22
申请号:US13475065
申请日:2012-05-18
申请人: Ju-su KIM
发明人: Ju-su KIM
IPC分类号: B29C45/72
CPC分类号: A61K9/4816 , A23P10/30
摘要: An apparatus for manufacturing a capsule by using vegetable gelatin is provided. Heating units are installed in a gelatin feeding line, which feeds gelatin in the form of a sheet, and a molding line to feed the gelatin in a predetermined temperature. The molded capsule is conveyed through a conveyer so that the molded capsule is stably dried and cured and a temperature of the conveyer is adjusted to control a temperature of the capsule. A length of the drying line is maximally increased within a narrow space, so that a film of the capsule made of the vegetable gelatin is gradually cured and dried without abrupt temperature variation, thereby preventing crack from occurring in the capsule, and preventing bonding parts of the capsule from being torn to improve the commercial value of the capsule.
摘要翻译: 提供了一种使用植物性明胶制造胶囊的装置。 加热单元安装在明胶进料管线中,其供给片状的明胶,以及在预定温度下进料明胶的成型线。 模塑胶囊通过输送机输送,使得模制的胶囊被稳定地干燥和固化,并且调节输送机的温度以控制胶囊的温度。 干燥线的长度在狭窄的空间内最大程度地增加,使得由植物明胶制成的胶囊的膜逐渐固化和干燥而没有突然的温度变化,从而防止在胶囊中发生裂纹,并且防止 胶囊被撕裂以提高胶囊的商业价值。
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公开(公告)号:US20070289157A1
公开(公告)日:2007-12-20
申请号:US11762883
申请日:2007-06-14
申请人: Ju Su KIM
发明人: Ju Su KIM
IPC分类号: F26B25/06
CPC分类号: F26B25/06 , F26B11/00 , F26B25/003
摘要: Disclosed is a dryer for a medical capsule. The dryer has a body including a rectangular frame and a dry box installed in the body. A gear wheel installed in the body and a gear array is formed in the dry box to engage with the gear wheel. Guide rollers are rotatably installed at both sides of an upper portion of the gear wheel, and a cover is provided to cover the dry box, which is accommodated in the body while partially protruding upward out of the body. A front plate is provided to open/close a front portion of the rectangular frame of the body, and a support plate is provided at a rear portion of the front plate in line with the guide rollers to support the dry box coming out of the body.
摘要翻译: 公开了一种用于医疗胶囊的干燥器。 干衣机具有主体,其包括矩形框架和安装在主体中的干燥箱体。 安装在本体中的齿轮和齿轮阵列形成在干燥箱中以与齿轮啮合。 引导辊可旋转地安装在齿轮的上部的两侧,并且设置有盖以覆盖容纳在主体中的干燥箱,同时部分地向外突出出体外。 提供前板以打开/关闭主体的矩形框架的前部,并且在前板的后部设置有与引导辊一致的支撑板,以支撑从箱体出来的干燥箱 。
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公开(公告)号:US06645951B1
公开(公告)日:2003-11-11
申请号:US09719608
申请日:2001-07-16
申请人: Jae Chon Jo , Hyun Suk Lim , Jong Min Kim , Ju Su Kim , Kazumi Morikawa , Yoshitake Kanbe , Myung Hwa Kim , Masahiro Nishimoto
发明人: Jae Chon Jo , Hyun Suk Lim , Jong Min Kim , Ju Su Kim , Kazumi Morikawa , Yoshitake Kanbe , Myung Hwa Kim , Masahiro Nishimoto
IPC分类号: C07D33506
CPC分类号: C07D335/06 , C07D311/58 , C07D405/04 , C07D405/06 , C07D407/06 , C07D413/06 , C07D417/06
摘要: The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds according to Formula I: The present invention further provides pharmaceutical compositions which possess anti-estrogenic activity and comprise at least one benzopyran compound of the invention and a method of treating breast cancer by administration of an effective amount of a benzopyran compound provided by the present invention.
摘要翻译: 本发明提供新的苯并吡喃化合物,其药学上可接受的盐和立体异构体,其中本发明的苯并吡喃化合物是式I的化合物。本发明还提供了具有抗雌激素活性的药物组合物,并且包含至少一种苯并吡喃化合物 本发明和通过施用有效量的本发明提供的苯并吡喃化合物来治疗乳腺癌的方法。
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公开(公告)号:US08696338B2
公开(公告)日:2014-04-15
申请号:US13475065
申请日:2012-05-18
申请人: Ju-su Kim
发明人: Ju-su Kim
IPC分类号: B29C45/78
CPC分类号: A61K9/4816 , A23P10/30
摘要: An apparatus for manufacturing a capsule by using vegetable gelatin is provided. Heating units are installed in a gelatin feeding line, which feeds gelatin in the form of a sheet, and a molding line to feed the gelatin in a predetermined temperature. The molded capsule is conveyed through a conveyer so that the molded capsule is stably dried and cured and a temperature of the conveyer is adjusted to control a temperature of the capsule. A length of the drying line is maximally increased within a narrow space, so that a film of the capsule made of the vegetable gelatin is gradually cured and dried without abrupt temperature variation, thereby preventing crack from occurring in the capsule, and preventing bonding parts of the capsule from being torn to improve the commercial value of the capsule.
摘要翻译: 提供了一种使用植物性明胶制造胶囊的装置。 加热单元安装在明胶进料管线中,其供给片状的明胶,以及在预定温度下进料明胶的成型线。 模塑胶囊通过输送机输送,使得模制的胶囊被稳定地干燥和固化,并且调节输送机的温度以控制胶囊的温度。 干燥线的长度在狭窄的空间内最大程度地增加,使得由植物明胶制成的胶囊的膜逐渐固化和干燥而没有突然的温度变化,从而防止在胶囊中发生裂纹,并且防止 胶囊被撕裂以提高胶囊的商业价值。
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