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    PEPTIDES FOR PROMOTING ANGIOGENESIS AND AN USE THEREOF
    1.
    发明申请
    PEPTIDES FOR PROMOTING ANGIOGENESIS AND AN USE THEREOF 有权
    促进血管生成的用途及其用途

    公开(公告)号：US20130085108A1

    公开(公告)日：2013-04-04

    申请号：US13637604

    申请日：2011-03-25

    申请人： Dae Ho Cho ,  Sa Ik Bang ,  Jeong Min Park ,  Sun Young Yoon ,  Sang Yoon Kim ,  Ha Rum Lee ,  Yoo Rim Park ,  Juah Son

    发明人： Dae Ho Cho ,  Sa Ik Bang ,  Jeong Min Park ,  Sun Young Yoon ,  Sang Yoon Kim ,  Ha Rum Lee ,  Yoo Rim Park ,  Juah Son

    IPC分类号： C07K7/06 ,  C07K5/103

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61L27/227 ,  C07K5/1008

    摘要： The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on promoting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial-skin and preparation of blood vessels for transplantation.

    摘要翻译： 本发明涉及促进血管生成的肽及其新用途。 更具体地，本发明涉及促进血管生成的肽，以及该肽用于促进血管发生和预防或治疗血管发生相关疾病的用途。 本发明的肽对促进血管生成具有极好的效果。 因此，用于预防或治疗血管生成相关疾病和用于制备皮瓣，伤口和烧伤愈合的再生，人造皮肤的植入和用于移植的血管的制备是有用的。

    NOVEL USE OF ERYTHROID DIFFERENTIATION REGULATOR 1 AS AN AGENT FOR TREATING CANCER
    4.
    发明申请
    NOVEL USE OF ERYTHROID DIFFERENTIATION REGULATOR 1 AS AN AGENT FOR TREATING CANCER 审中-公开
    艾滋病毒分化调节剂1作为治疗癌症的药物的新用途

    公开(公告)号：US20130217635A1

    公开(公告)日：2013-08-22

    申请号：US13637155

    申请日：2011-03-23

    申请人： Dae Ho Cho ,  Sa Ik Bang ,  Jeong Min Park ,  Min Kyung Jung ,  Ha Rum Lee ,  Yoo Rim Park ,  Seung Beom Park ,  Juah Son ,  Youn Kyung Houh

    发明人： Dae Ho Cho ,  Sa Ik Bang ,  Jeong Min Park ,  Min Kyung Jung ,  Ha Rum Lee ,  Yoo Rim Park ,  Seung Beom Park ,  Juah Son ,  Youn Kyung Houh

    IPC分类号： A61K38/17

    CPC分类号： A61K38/1709 ,  A61K48/00 ,  C07K14/4702

    摘要： The present invention relates to a novel use of erythroid differentiation regulator 1 (Erdr1) as an agent for treating cancer. More particularly, it relates to an use of Erdr1 or an expression vector including a polynucleotide encoding the same for preventing and inhibiting cancer metastasis, an use of Erdr1 or an expression vector including a polynucleotide encoding the same for preventing and treating cancer, an use of an antibody specific for Erdr1 for diagnosing cancer, or a method for screening agents for regulating cancer metastasis or cancer cells migration. The Erdr1 is negatively regulated by IL-18 expression and it suppresses migration, invasion and metastasis of cancer or tumor cell by expression of HSP90 and generation of ROI. And an Erdr1 recombinant protein promotes NK-cell killing activity against cancer cell. Accordingly, the Erdr1 and an expression vector comprising polynucleotide encoding the same and recombinant protein suppress cancer metastasis and bring an effect on activation of immune cells, and therefore can be useful for preventing, treating and diagnosing cancer.

    摘要翻译： 本发明涉及红细胞分化调节剂1（Erdr1）作为癌症治疗剂的新用途。 更具体地，涉及使用Erdr1或包含编码该多核苷酸的表达载体来预防和抑制癌症转移，使用Erdr1或包含编码该多核苷酸的表达载体来预防和治疗癌症的用途 用于诊断癌症的Erdr1特异性抗体或用于调节癌症转移或癌细胞迁移的筛选剂的方法。 Erdr1受IL-18表达负调控，通过HSP90的表达和ROI的产生抑制癌症或肿瘤细胞的迁移，侵袭和转移。 并且Erdr1重组蛋白促进针对癌细胞的NK细胞杀伤活性。 因此，Erdr1和包含编码该多核苷酸的多核苷酸的表达载体和重组蛋白抑制癌症转移并对免疫细胞的活化产生影响，因此可用于预防，治疗和诊断癌症。