公开(公告)号：US5753260A

公开(公告)日：1998-05-19

申请号：US422633

申请日：1995-04-14

申请人： Carl R. Alving ,  Julie Kenner ,  Glenn M. Swartz, Jr. ,  John W. Madsen

发明人： Carl R. Alving ,  Julie Kenner ,  Glenn M. Swartz, Jr. ,  John W. Madsen

IPC分类号： A61K9/127 ,  A61K31/575 ,  A61K31/58 ,  A61K31/66 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/39 ,  C07K14/445 ,  C07K16/12 ,  C07K16/18 ,  C07K16/44 ,  G01N33/92

CPC分类号： A61K31/575 ,  A61K31/58 ,  A61K31/66 ,  A61K39/0002 ,  A61K39/0012 ,  A61K39/02 ,  A61K39/39 ,  A61K9/127 ,  A61K9/1271 ,  B82Y5/00 ,  C07K14/445 ,  C07K16/1203 ,  C07K16/18 ,  C07K16/44 ,  G01N33/92 ,  A61K2039/55505 ,  A61K2039/5555 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K38/00 ,  A61K39/00 ,  G01N2800/044

摘要： The present invention relates to immunoreactive compositions and methods for immunizing humans or animals against sterols, such as cholesterol and its derivatives, and their use in methods for reducing the serum cholesterol levels of the immunized individuals and to retard or reduce the severity of atherosclerosis or atherosclerosis plaques caused by ingestion of dietary cholesterol. Another embodiment of the present invention encompasses ergosterol or ergosterol derivative compositions useful for the treatment or prevention of fungal infection, and methods of use thereof. Yet another aspect of the invention is dairy products containing anti-ergosterol antibodies produced by dairy animals immunized against ergosterol according to the present invention and methods of making thereof. A further aspect of the invention is a diagnostic assay for determining whether a human or animal has a fungal infection.

公开(公告)号：US06224902B1

公开(公告)日：2001-05-01

申请号：US09023256

申请日：1998-02-13

申请人： Carl R. Alving ,  Julie Kenner ,  Glenn M. Swartz, Jr. ,  John W. Madsen

发明人： Carl R. Alving ,  Julie Kenner ,  Glenn M. Swartz, Jr. ,  John W. Madsen

IPC分类号： A61K9127

CPC分类号： A61K31/575 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/58 ,  A61K31/66 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0002 ,  A61K39/0012 ,  A61K39/02 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/5555 ,  A61K2039/55555 ,  A61K2039/55572 ,  B82Y5/00 ,  C07K14/445 ,  C07K16/1203 ,  C07K16/18 ,  C07K16/44 ,  G01N33/92 ,  G01N2800/044

摘要： The present invention relates to immunoreactive vaccine compositions for immunizing humans or animals against sterols, such as cholesterol and its derivatives, and their use in methods for reducing the serum cholesterol levels of the immunized individuals and to retard or reduce the severity of artherosclerosis or artherosclerosis plaques caused by ingestion of dietary cholesterol.

摘要翻译： 本发明涉及用于免疫人或动物对抗甾醇（例如胆固醇及其衍生物）的免疫反应性疫苗组合物，以及它们在降低免疫个体的血清胆固醇水平的方法中的用途，并且用于延缓或降低动脉粥样硬化或动脉粥样硬化斑块的严重程度 由摄入膳食胆固醇引起。