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    Tiered on-demand location-based service and infrastructure
    2.
    发明申请
    Tiered on-demand location-based service and infrastructure 有权
    分层的按需定位服务和基础设施

    公开(公告)号：US20060145838A1

    公开(公告)日：2006-07-06

    申请号：US11016163

    申请日：2004-12-17

    申请人： Julio Alvarez ,  Phuc Do ,  Justin Pierce ,  Susan Wince

    发明人： Julio Alvarez ,  Phuc Do ,  Justin Pierce ,  Susan Wince

    IPC分类号： G08B1/08

    CPC分类号： G06Q30/02 ,  A47F10/04

    摘要： A location-based service includes detecting the relative motion of an on-site resource, such as a shopping cart, in addition to detecting the absolute position of the on-site resource, and displaying information on the on-site resource. The displayed information is based upon the detected relative motion and the detected absolute position. The relative motion is tracked and a position on a floor plan is deduced. This deduced position is adjusted, for example, synchronized or reset, as a function of and in response to the detected absolute position.

    摘要翻译： 基于位置的服务包括检测现场资源（例如购物车）的相对运动，以及检测现场资源的绝对位置，以及在现场资源上显示信息。 所显示的信息基于检测到的相对运动和检测到的绝对位置。 跟踪相对运动，并推导出平面图上的位置。 该推断的位置被调整为例如同步或重置，作为并且响应于检测到的绝对位置的函数。

    Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine
    3.
    发明授权
    Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine 有权
    协同组合包括N-酰化4-羟基苯胺衍生物和咖啡因

    公开(公告)号：US07064140B2

    公开(公告)日：2006-06-20

    申请号：US10459911

    申请日：2003-06-12

    申请人： Carlos Sunkel ,  Nicolas G. Bazan ,  Dennis Paul ,  Julio Alvarez-Builla

    发明人： Carlos Sunkel ,  Nicolas G. Bazan ,  Dennis Paul ,  Julio Alvarez-Builla

    IPC分类号： A61K31/425

    CPC分类号： A61K31/428 ,  A61K31/425 ,  A61K31/485 ,  A61K31/522 ,  A61K2300/00

    摘要： The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.

    摘要翻译： 本发明涉及与咖啡因紧密混合的阿片样物质和非阿片样物质止痛剂的药物组合，以及通过亚烷基桥连接至1,2-二羟基苯甲酸的氮原子的一系列N-酰化4-羟基苯基胺衍生物的止痛剂， 苯并异噻唑-3（2H） - 酮1,1-二氧化物组及其用于减轻哺乳动物疼痛的方法。 镇痛组合显示出增强的止痛效力，无解热活性，不抑制血液凝固，肝毒作用小。

    SYNTHESIS AND USES OF PYROGLUTAMIC ACID DERIVATIVES
    4.
    发明申请
    SYNTHESIS AND USES OF PYROGLUTAMIC ACID DERIVATIVES 有权
    吡咯烷酸衍生物的合成和用途

    公开(公告)号：US20070249678A1

    公开(公告)日：2007-10-25

    申请号：US11380730

    申请日：2006-04-28

    申请人： Julio Alvarez Builla Gomez ,  Jose Novella Robisco ,  Ma Matia Martin ,  Sonia Serna Pereda

    发明人： Julio Alvarez Builla Gomez ,  Jose Novella Robisco ,  Ma Matia Martin ,  Sonia Serna Pereda

    IPC分类号： A61K31/454 ,  A61K31/4025 ,  A61K31/4015 ,  C07D403/02

    CPC分类号： C07K5/06173 ,  A61K31/4439 ,  A61K38/00 ,  C07D401/06 ,  C07D487/10 ,  Y02P20/55

    摘要： Novel pyroglutamic acid derivatives (I), wherein R1 is −OH, −ORa, wherein Ra is alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, aralkyl or heterocyclyl; R2, R3 and R4 are independently H, a nitrogen protecting group which hydrolyzes under acidic conditions or phtalamide; X is a pharmaceutically acceptable anion; and Y is a N-containing group; either in the form of their isolated optically active stereoisomers or in the form of mixtures thereof, are useful compounds for enhancing an immuneresponse in a subject and/or for treating tumours, bacterial, fungal or viral infections, or autoimmune diseases.

    摘要翻译： 新型焦谷氨酸衍生物（I），其中R 1是-OH，-OR a，其中R a是烷基，环烷基，烯基，环烯基，芳基，芳烷基或杂环基; R 2，R 3和R 4独立地是H，在酸性条件下水解的氮保护基或邻苯二甲酰胺; X是药学上可接受的阴离子; Y为含氮基团; 以其分离的光学活性立体异构体的形式或以其混合物的形式，是用于增强受试者和/或治疗肿瘤，细菌，真菌或病毒感染或自身免疫性疾病的免疫应答的有用化合物。

    Tiered on-demand location-based tracking service and infrastructure
    5.
    发明申请
    Tiered on-demand location-based tracking service and infrastructure 有权
    分层按需定位的跟踪服务和基础设施

    公开(公告)号：US20060136285A1

    公开(公告)日：2006-06-22

    申请号：US11016615

    申请日：2004-12-17

    申请人： Julio Alvarez ,  Phuc Do ,  Justin Pierce ,  Susan Wince

    发明人： Julio Alvarez ,  Phuc Do ,  Justin Pierce ,  Susan Wince

    IPC分类号： G06F17/30

    CPC分类号： G06Q10/08 ,  G06Q30/0201 ,  G06Q30/06 ,  G06Q30/0643

    摘要： A location-based service includes detecting the relative motion of an on-site resource, detecting the absolute position of the on-site resource, and tracking the position of the on-site resource. The position is tracked by deriving a deduced position based on the detected relative motion and adjusting the deduced position as a function of and in response to the detected absolute position. According to one embodiment, the on-site resource can be a shopping cart and the tracking includes recording a travel pattern of the shopping cart as it moves through a site floor plan such that the travel pattern is reproducible. Preferably, the recorded travel pattern includes travel patterns within an aisle in the site floor plan such that the recorded patterns include travel along the length of the aisle and travel having components which are perpendicular to the length of the aisle.

    摘要翻译： 基于位置的服务包括检测现场资源的相对运动，检测现场资源的绝对位置以及跟踪现场资源的位置。 通过基于检测到的相对运动导出推导位置并根据检测到的绝对位置调整推导位置作为函数并响应于该位置来跟踪位置。 根据一个实施例，现场资源可以是购物车，并且跟踪包括在购物车移动通过场地平面图时记录购物车的行进模式，使得旅行模式是可再现的。 优选地，所记录的行驶模式包括现场平面图中的过道内的旅行图案，使得记录的图案包括沿着通道的长度的行进以及具有垂直于通道的长度的分量的行程。

    Analgesic compounds, their synthesis and pharmaceutical compositions containing them
    7.
    发明授权
    Analgesic compounds, their synthesis and pharmaceutical compositions containing them 有权
    止痛化合物，它们的合成和含有它们的药物组合物

    公开(公告)号：US06806291B1

    公开(公告)日：2004-10-19

    申请号：US10682744

    申请日：2003-10-09

    申请人： Carlos Sunkel ,  Julio Alvarez-Builla ,  Nicolas G. Bazan ,  Anthony Vaccarino

    发明人： Carlos Sunkel ,  Julio Alvarez-Builla ,  Nicolas G. Bazan ,  Anthony Vaccarino

    IPC分类号： A61K31195

    CPC分类号： C07C311/19

    摘要： New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepatotoxic effect, making them more useful than conventional non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of chronic pain.

    摘要翻译： 公开了通过水解N-酰化的4-羟基苯基胺衍生物制备的新的止痛化合物，其合成和含有它们的药物组合物。 这些化合物惊人地具有很高的止痛活性，具有很小的肝毒性作用，使得它们比常规的非甾体抗炎药（NSAID）在治疗慢性疼痛中更有用。

    Tiered on-demand location-based tracking service and infrastructure
    9.
    发明授权
    Tiered on-demand location-based tracking service and infrastructure 有权
    分层按需定位的跟踪服务和基础设施

    公开(公告)号：US07996281B2

    公开(公告)日：2011-08-09

    申请号：US11016615

    申请日：2004-12-17

    申请人： Julio Alvarez ,  Phuc Ky Do ,  Justin Monroe Pierce ,  Susan Elizabeth Wince

    发明人： Julio Alvarez ,  Phuc Ky Do ,  Justin Monroe Pierce ,  Susan Elizabeth Wince

    IPC分类号： G06Q10/00

    CPC分类号： G06Q10/08 ,  G06Q30/0201 ,  G06Q30/06 ,  G06Q30/0643

    摘要： A location-based service includes detecting the relative motion of an on-site resource, detecting the absolute position of the on-site resource, and tracking the position of the on-site resource. The position is tracked by deriving a deduced position based on the detected relative motion and adjusting the deduced position as a function of and in response to the detected absolute position. According to one embodiment, the on-site resource can be a shopping cart and the tracking includes recording a travel pattern of the shopping cart as it moves through a site floor plan such that the travel pattern is reproducible. Preferably, the recorded travel pattern includes travel patterns within an aisle in the site floor plan such that the recorded patterns include travel along the length of the aisle and travel having components which are perpendicular to the length of the aisle.

    摘要翻译： 基于位置的服务包括检测现场资源的相对运动，检测现场资源的绝对位置以及跟踪现场资源的位置。 通过基于检测到的相对运动导出推导位置并根据检测到的绝对位置调整推导位置作为函数并响应于该位置来跟踪位置。 根据一个实施例，现场资源可以是购物车，并且跟踪包括在购物车移动通过场地平面图时记录购物车的行进模式，使得旅行模式是可再现的。 优选地，所记录的行驶模式包括现场平面图中的过道内的旅行图案，使得记录的图案包括沿着通道的长度的行进以及具有垂直于通道的长度的分量的行程。

    Tiered on-demand location-based service and infrastructure
    10.
    发明授权
    Tiered on-demand location-based service and infrastructure 有权
    分层的按需定位服务和基础设施

    公开(公告)号：US07183910B2

    公开(公告)日：2007-02-27

    申请号：US11016163

    申请日：2004-12-17

    申请人： Julio Alvarez ,  Phuc Ky Do ,  Justin Monroe Pierce ,  Susan Elizabeth Wince

    发明人： Julio Alvarez ,  Phuc Ky Do ,  Justin Monroe Pierce ,  Susan Elizabeth Wince

    IPC分类号： G08B1/08 ,  H04Q7/00

    CPC分类号： G06Q30/02 ,  A47F10/04

    摘要： A location-based service includes detecting the relative motion of an on-site resource, such as a shopping cart, in addition to detecting the absolute position of the on-site resource, and displaying information on the on-site resource. The displayed information is based upon the detected relative motion and the detected absolute position. The relative motion is tracked and a position on a floor plan is deduced. This deduced position is adjusted, for example, synchronized or reset, as a function of and in response to the detected absolute position.

    摘要翻译： 基于位置的服务包括检测现场资源（例如购物车）的相对运动，以及检测现场资源的绝对位置，以及在现场资源上显示信息。 所显示的信息基于检测到的相对运动和检测到的绝对位置。 跟踪相对运动，并推导出平面图上的位置。 该推断的位置被调整为例如同步或重置，作为并且响应于检测到的绝对位置的函数。