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公开(公告)号:US07125565B2
公开(公告)日:2006-10-24
申请号:US10433515
申请日:2001-11-30
申请人: Jun Sugishita , Makoto Kigoshi , Setsuko Yano , Hideki Morita , Yasuki Kato
发明人: Jun Sugishita , Makoto Kigoshi , Setsuko Yano , Hideki Morita , Yasuki Kato
IPC分类号: B01D11/02
CPC分类号: A61K31/56 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K31/122 , A61K31/335 , A61K31/522
摘要: An object of the present invention is to provide a composition improved in the solubility or oral absorbability.The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.
摘要翻译: 本发明的目的是提供改善溶解性或口服吸收性的组合物。 本发明提供一种组合物,其包含微溶于水的组分,表面活性剂和亲水性聚合物的三种组分,并且可通过在水存在下通过湿法制粒获得。
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公开(公告)号:US20090012051A1
公开(公告)日:2009-01-08
申请号:US11908232
申请日:2006-03-15
申请人: Jun Sugishita , Yohei Yamazoe , Maho Nishikawahara , Daisuke Harada , Katsuya Kobayashi , Yoshikazu Tashiro
发明人: Jun Sugishita , Yohei Yamazoe , Maho Nishikawahara , Daisuke Harada , Katsuya Kobayashi , Yoshikazu Tashiro
IPC分类号: A61K31/443 , A61K31/56 , A61P17/00
CPC分类号: A61K9/0014 , A61K31/357 , A61K31/443 , A61K31/56 , A61K31/565 , A61K47/06 , A61K47/14 , A61K47/44 , A61K2300/00
摘要: The present invention provides an external preparation which comprises 7-[2-(3,5-dichloro-4-pyridyl)-1-oxoethyl]-4-methoxy-spiro[1,3-benzodioxol-2,1′-cyclopentane] represented by Formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, comprising 0.5 to 15% by mass of a solvent component in which the solubility of the active ingredient is 4 mg/mL or more, and the like.
摘要翻译: 本发明提供外部制剂,其包含7- [2-(3,5-二氯-4-吡啶基)-1-氧代乙基] -4-甲氧基 - 螺[1,3-苯并间二氧杂环戊烯-2,1'-环戊烷] 由式(I)表示的化合物或其药学上可接受的盐作为活性成分,含有0.5〜15质量%的活性成分的溶解性为4mg / mL以上的溶剂成分等。
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公开(公告)号:US20070065516A1
公开(公告)日:2007-03-22
申请号:US11544320
申请日:2006-10-06
申请人: Jun Sugishita , Makoto Kigoshi , Setsuko Yano , Hideki Morita , Yasuki Kato
发明人: Jun Sugishita , Makoto Kigoshi , Setsuko Yano , Hideki Morita , Yasuki Kato
IPC分类号: A61K9/14
CPC分类号: A61K31/56 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K31/122 , A61K31/335 , A61K31/522
摘要: An object of the present invention is to provide a composition improved in the solubility or oral absorbability. The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.
摘要翻译: 本发明的目的是提供改善溶解性或口服吸收性的组合物。 本发明提供一种组合物,其包含微溶于水的组分,表面活性剂和亲水性聚合物的三种组分,并且可通过在水存在下通过湿法制粒获得。
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公开(公告)号:US07799860B2
公开(公告)日:2010-09-21
申请号:US11544320
申请日:2006-10-06
申请人: Jun Sugishita , Makoto Kigoshi , Setsuko Yano , Hideki Morita , Yasuki Kato
发明人: Jun Sugishita , Makoto Kigoshi , Setsuko Yano , Hideki Morita , Yasuki Kato
IPC分类号: B01D11/02
CPC分类号: A61K31/56 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K31/122 , A61K31/335 , A61K31/522
摘要: An object of the present invention is to provide a composition improved in the solubility or oral absorbability.The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.
摘要翻译: 本发明的目的是提供改善溶解性或口服吸收性的组合物。 本发明提供一种组合物,其包含微溶于水的组分,表面活性剂和亲水性聚合物的三种组分,并且可通过在水存在下通过湿法制粒获得。
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