公开(公告)号：US08507539B2

公开(公告)日：2013-08-13

申请号：US12997864

申请日：2009-06-12

申请人： Andrew John Harvey ,  Bernard Luke Flynn ,  Jorgen Alvar Mould ,  Dharam Paul ,  Gurmit Singh Gill ,  Justin Anthony Ripper ,  Rachel Christine Cooke ,  Julia Stephanie Crossman ,  Jonathan Bayldon Baell ,  Nathan Wayne Kuchel ,  Rajinder Singh

发明人： Andrew John Harvey ,  Bernard Luke Flynn ,  Jorgen Alvar Mould ,  Dharam Paul ,  Gurmit Singh Gill ,  Justin Anthony Ripper ,  Rachel Christine Cooke ,  Julia Stephanie Crossman ,  Jonathan Bayldon Baell ,  Nathan Wayne Kuchel ,  Rajinder Singh

IPC分类号： A61K31/423 ,  C07D263/54

CPC分类号： C07D263/56 ,  C07D413/12

摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

公开(公告)号：US20110166130A1

公开(公告)日：2011-07-07

申请号：US12997864

申请日：2009-06-12

申请人： Andrew John Harvey ,  Bernard Luke Flynn ,  Jorgen Alvar Mould ,  Dharam Paul ,  Gurmit Singh Gill ,  Justin Anthony Ripper ,  Rachel Christine Cooke ,  Julia Stephanie Crossman ,  Jonathan Bayldon Baell ,  Nathan Wayne Kuchel ,  Rajinder Singh

发明人： Andrew John Harvey ,  Bernard Luke Flynn ,  Jorgen Alvar Mould ,  Dharam Paul ,  Gurmit Singh Gill ,  Justin Anthony Ripper ,  Rachel Christine Cooke ,  Julia Stephanie Crossman ,  Jonathan Bayldon Baell ,  Nathan Wayne Kuchel ,  Rajinder Singh

IPC分类号： A61K31/54 ,  C07D413/12 ,  C07D263/54 ,  C07D417/12 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/421 ,  C12N5/0783 ,  A61P37/02

CPC分类号： C07D263/56 ,  C07D413/12

摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。