公开(公告)号：US20110059994A1

公开(公告)日：2011-03-10

申请号：US12865127

申请日：2008-01-31

Applicant: Justin Changjoon Lee ,  Eun-Joo Roh ,  Jin-Kyu Choi ,  Kyung-Suk Han ,  Jung-Eun Park ,  Sang-Soo Kang

Inventor： Justin Changjoon Lee ,  Eun-Joo Roh ,  Jin-Kyu Choi ,  Kyung-Suk Han ,  Jung-Eun Park ,  Sang-Soo Kang

IPC: A61K31/522 ,  A61P35/00 ,  A61P25/00

CPC classification number: A61K31/522

Abstract: A composition for preventing and/or treating brain tumor, containing caffeine and/or its analog, and/or their pharmaceutically acceptable salt, as an active ingredient, is provided. The composition for preventing or treating brain tumor has an activity to inhibit invasion, migration, and proliferation of brain tumor cells, and thereby very effective for the prevention and treatment of brain tumor.

Abstract translation: 提供了用于预防和/或治疗含有咖啡因和/或其类似物的脑肿瘤和/或其药学上可接受的盐作为活性成分的组合物。 用于预防或治疗脑肿瘤的组合物具有抑制脑肿瘤细胞的侵袭，迁移和增殖的活性，因此对预防和治疗脑肿瘤非常有效。

公开(公告)号：US20120232127A1

公开(公告)日：2012-09-13

申请号：US13418486

申请日：2012-03-13

Applicant: Justin Changjoon LEE ,  Dong-Ho Woo ,  Hyung-Ju Park ,  Hye-Kyung Park

Inventor： Justin Changjoon LEE ,  Dong-Ho Woo ,  Hyung-Ju Park ,  Hye-Kyung Park

IPC: A61K31/7088 ,  A61K31/26 ,  A61K31/196 ,  A61P25/00 ,  A61K31/44

CPC classification number: C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: A novel use of anion channels, preferably Ca2+-activated anion channels (CAACs), in regulating release of neurotransmitters from neurons and/or astrocytes is provided. More specifically, CAAC activity regulators, agents for regulating neurotransmitter release comprising such CAAC activity regulators, and methods of screening agents for regulating neurotransmitter release using CAAC as a target.

Abstract translation: 提供阴离子通道，优选Ca2 +活化阴离子通道（CAAC）在调节神经元和/或星形胶质细胞释放神经递质中的新用途。 更具体地，CAAC活性调节剂，用于调节包含这种CAAC活性调节剂的神经递质释放剂，以及使用CAAC作为靶标调节神经递质释放调节剂的方法。

公开(公告)号：US20110201668A1

公开(公告)日：2011-08-18

申请号：US12865126

申请日：2008-01-30

Applicant: Justin Changjoon Lee ,  Dong-Ho Woo ,  Hyung-Ju Park ,  Hye-Kyung Park

Inventor： Justin Changjoon Lee ,  Dong-Ho Woo ,  Hyung-Ju Park ,  Hye-Kyung Park

IPC: A61K31/7088 ,  C07H21/02 ,  C12N15/63 ,  C12Q1/02 ,  C12Q1/68

CPC classification number: C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: A novel use of anion channels, preferably Ca2+-activated anion channels (CAACs), in regulating release of neurotransmitters from neurons and/or astrocytes is provided. More specifically, CAAC activity regulators, agents for regulating neurotransmitter release comprising such CAAC activity regulators, and methods of screening agents for regulating neurotransmitter release using CAAC as a target.

Abstract translation: 提供阴离子通道，优选Ca2 +活化阴离子通道（CAAC）在调节神经元和/或星形胶质细胞释放神经递质中的新用途。 更具体地，CAAC活性调节剂，用于调节包含这种CAAC活性调节剂的神经递质释放剂，以及使用CAAC作为靶标调节神经递质释放调节剂的方法。

公开(公告)号：US20110039869A1

公开(公告)日：2011-02-17

申请号：US12865128

申请日：2008-01-31

Applicant: Justin Changjoon Lee ,  Sang-Soo Kang ,  Kyung-Suk Han ,  Eun-Joo Roh ,  Jae-Yong Park

Inventor： Justin Changjoon Lee ,  Sang-Soo Kang ,  Kyung-Suk Han ,  Eun-Joo Roh ,  Jae-Yong Park

IPC: A61K31/522 ,  A61P29/00 ,  A61P25/00 ,  A61P25/30 ,  A61P35/00 ,  A61P3/10 ,  A61P13/10 ,  A61P9/00 ,  A61P9/12 ,  A61P9/10 ,  A61P13/12

CPC classification number: A61K31/522

Abstract: An agent for inhibiting the activity of inositol-1,4,5-triphospate receptor subtype 3 (IP3R3), containing caffeine and/or its analogs, and/or their pharmaceutically acceptable salts, as an active ingredient, is provided. A composition for preventing and/or treating a disease associated with Ca2+ release through IP3R3, containing the IP3R3 inhibiting agent, is also provided.

Abstract translation: 提供了用于抑制含有咖啡因和/或其类似物的肌醇-1,4,5-三磷酸受体亚型3（IP3R3）和/或其药学上可接受的盐作为活性成分的活性的药剂。 还提供了用于预防和/或治疗与包含IP3R3抑制剂的IP3R3释放相关的疾病的组合物。