公开(公告)号：US20250041483A1

公开(公告)日：2025-02-06

申请号：US18718069

申请日：2021-12-09

Applicant: KOC UNIVERSITESI

Inventor： Kerem PEKKAN ,  Hummaira Banu SIDDIQUI ,  Merve CELIK

IPC: A61L27/36 ,  C12N15/113

Abstract: A genetically modified bioprosthetic heart valve and a production method thereof are provided. The production method includes two critical steps for the invention to achieve its related objectives. These criteria are the molecular modification step and subsequent decellularization of animal-based heart valve in valve culture, where the molecular modification step involves an electroporation system and siRNA molecules.

公开(公告)号：US12082236B2

公开(公告)日：2024-09-03

申请号：US17430339

申请日：2019-02-12

Applicant: KOC UNIVERSITESI

Inventor： Goksu Karadag ,  Sinem Coleri Ergen ,  Yalcin Sadi ,  Recep Gul

IPC: H04W72/543 ,  H04W4/70 ,  H04W72/0453 ,  H04W72/56

CPC classification number: H04W72/543 ,  H04W4/70 ,  H04W72/0453 ,  H04W72/56

Abstract: A semi-persistent scheduling method of machine-type communications specifically for cellular devices and a system employing the semi-persistent scheduling method are provided. Three algorithmic methods act in cooperation with allocating smartest and fastest possible incarnations of a resource handling in a cellular network setting, exploiting an inherent periodicity of a machine-to-machine communication taking place; a high priority cluster takes precedence over another cluster, before assigned to Unit Frequency Bands (UFB) with a given width, any device with a set priority according to a quality-of-service requirement allocation of the any device is executed on the UFB.

公开(公告)号：US20240264162A1

公开(公告)日：2024-08-08

申请号：US18566649

申请日：2022-06-03

Applicant: KOC UNIVERSITESI

Inventor： Nurhan SICAKKAN OZLU ,  Busra HARMANDA

IPC: G01N33/574

CPC classification number: G01N33/57496 ,  G01N2333/4742 ,  G01N2440/14

Abstract: A biomarker and a method of using the biomarker for the detection of dividing cancer cells specifically in the cytokinesis phase, based on the Keratin 8 S34 phosphorylation in dividing cancerous cells are provided. The method includes obtaining a biological sample and preparing a biological extract from the biological sample; determining the presence of the biomarker in the biological extract by qualitative and quantitative methods; where the biomarker is an indicator configured for indicating the dividing cancerous cell in the cytokinesis phase.

公开(公告)号：US20240000331A1

公开(公告)日：2024-01-04

申请号：US18035147

申请日：2021-11-03

Applicant: KOC UNIVERSITESI

Inventor： Levent BEKER ,  Rahul SINGH

IPC: A61B5/03 ,  A61B5/00

CPC classification number: A61B5/031 ,  A61B5/6868 ,  A61B2562/0247 ,  A61B2562/12

Abstract: A novel bioresorbable intracranial pressure sensor fabricated using readily available bioresorbable materials which are compatible with standard microfabrication technology is provided. The intracranial pressure sensor can also stay operational for a relevant time scale and can transfer data wirelessly.

公开(公告)号：US20230078642A1

公开(公告)日：2023-03-16

申请号：US17785970

申请日：2019-12-16

Applicant: KOC UNIVERSITESI

Inventor： Ibrahim Halil KAVAKLI ,  Metin TURKAY ,  Yagmur Umay DORUK ,  Darya YARPARVAR

IPC: A61K31/352 ,  A61P25/00

Abstract: A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and/or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and/or prevention of disorders associated with the circadian rhythm.

公开(公告)号：US20220132520A1

公开(公告)日：2022-04-28

申请号：US17430339

申请日：2019-02-12

Applicant: KOC UNIVERSITESI

Inventor： Goksu KARADAG ,  Sinem COLERI ERGEN ,  Yalcin SADI ,  Recep GUL

IPC: H04W72/08 ,  H04W4/70 ,  H04W72/10 ,  H04W72/04

Abstract: A semi-persistent scheduling method of machine-type communications specifically for cellular devices and a system employing the semi-persistent scheduling method are provided. Three algorithmic methods act in cooperation with allocating smartest and fastest possible incarnations of a resource handling in a cellular network setting, exploiting an inherent periodicity of a machine-to-machine communication taking place; a high priority cluster takes precedence over another cluster, before assigned to Unit Frequency Bands (UFB) with a given width, any device with a set priority according to a quality-of-service requirement allocation of the any device is executed on the UFB.

公开(公告)号：US20210275548A1

公开(公告)日：2021-09-09

申请号：US17255572

申请日：2018-06-25

Applicant: ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI ,  SABANCI UNIVERSITESI ,  KOC UNIVERSITESI

Inventor： Meltem MUFTUOGLU ,  Batu ERMAN ,  Burak ERMAN

IPC: A61K31/655 ,  A61P35/00

Abstract: Pol γ protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol γ. The compounds were shown to directly interact with Pol γ and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.

公开(公告)号：US10942102B2

公开(公告)日：2021-03-09

申请号：US15940823

申请日：2018-03-29

Applicant: KOC Universitesi

Inventor： Hakan Urey ,  Goksen Goksenin Yaralioglu ,  Fehmi Civitci ,  Yusuf Samet Yaras ,  Gokhan Saglam

IPC: G01N11/02 ,  G01N11/16 ,  G01N9/00 ,  G01N11/10 ,  G01N11/00

Abstract: A sensing device for measuring physical properties of fluid medium uses fiber based cantilevers embedded in a cartridge. The cartridge may include: at least one fluidic channel, at least one light channel, at least one chamber located at the intersection of the fluidic channel and the light channel, and at least one light guide placed in the light channel. The light guide is at least partially contained in the respective chamber. The light guide has a movable section. The vibration of the movable section may be externally actuatable.

公开(公告)号：US20210023239A1

公开(公告)日：2021-01-28

申请号：US16978067

申请日：2018-03-10

Applicant: KOC UNIVERSITESI ,  SABANCI UNIVERSITESI ,  SABANCI UNIVERSITESI NANOTEKNOLOJI ARASTIRMA VE UYGULAMA MERKEZI

Inventor： Havva Yagci ACAR ,  Devrim GOZUACIK ,  Ali KOSAR ,  Ozlem UNAL ,  Muhammed KOCAK ,  Yunus AKKOC ,  Merve ZUVIN

IPC: A61K47/68 ,  A61K47/54 ,  A61K47/69 ,  A61K33/243 ,  A61K41/00

Abstract: The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.

公开(公告)号：US10531070B2

公开(公告)日：2020-01-07

申请号：US15780770

申请日：2015-12-07

Applicant: KOC Universitesi

Inventor： Hakan Urey ,  Shoaib Soomro ,  Muhsin Eralp

IPC: H04N13/225 ,  G02B27/01 ,  H04N7/14 ,  H04N13/351 ,  H04N13/363 ,  H04N13/282 ,  G02B5/128 ,  G02B27/22 ,  G03B17/54 ,  G03B21/602

Abstract: A system is preferably in the form of a wearable system combined with a double-function image display and image capturing screen. The system is intended to be used to display projected images on the screen and capture the 3D ambient using the image formations from the screen by means of a camera. The system more particularly relates to a display and imaging system comprising an image capturing device, a projector assembly and a passive screen, said image capturing device capturing at least one view being formed by the said passive screen in optical communication therewith.