公开(公告)号：US20070134231A1

公开(公告)日：2007-06-14

申请号：US11601389

申请日：2006-11-17

Applicant: Dharmendra Jani ,  Kai Kwok ,  Gregory McIntire ,  Bruce Pfeffer ,  Afshin Shafiee ,  Ruiwen Shi ,  Srini Venkatesh ,  Hongna Wang ,  Yan Huang ,  Stephen Davio

Inventor： Dharmendra Jani ,  Kai Kwok ,  Gregory McIntire ,  Bruce Pfeffer ,  Afshin Shafiee ,  Ruiwen Shi ,  Srini Venkatesh ,  Hongna Wang ,  Yan Huang ,  Stephen Davio

IPC: A61K38/48 ,  A61K31/198

CPC classification number: C12N9/50 ,  A61K31/198 ,  C12N9/6435 ,  C12N9/96 ,  C12Y304/21007

Abstract: A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.

Abstract translation: 长效酶的组合物包含在包含缓冲液和选自氨甲环酸，ε-氨基己酸和除了氨甲环酸和ε-氨基己酸之外的L-赖氨酸的类似物的制剂中的酶， 其组合，及其混合物。 所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA​​，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。 用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。 该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。 在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

公开(公告)号：US20070102414A1

公开(公告)日：2007-05-10

申请号：US10582908

申请日：2004-12-10

Applicant: Yong Jiang ,  Bas Oosterman ,  Boon Ching ,  Kai Kwok ,  Mohankumar Valiyambath Krishnan

Inventor： Yong Jiang ,  Bas Oosterman ,  Boon Ching ,  Kai Kwok ,  Mohankumar Valiyambath Krishnan

IPC: D06F75/08

CPC classification number: D06F75/22 ,  D06F75/10 ,  D06F75/18

Abstract: The invention relates to a steam ironing device (1) comprising a water supply device (4), a steam generator (6) for generating steam, heating means (13) for heating the steam generator, at least one atomizating device (10, 15), a valve (11) provided in a flow path (9) between the steam generator and the atomizing device, and an electric pump (5) for delivering water from said water supply device to said steam generator. To obtain wet steam at the atomizing device the ironing device comprises control means (7) for controlling the power of the heating means (13) of the steam generator, for controlling the flow rate of the pump, and for controlling the opening and closing of said valve, said valve being open if the ratio between the flow rate (g/min) of the pump and the power (W) of the heating means is in a range of 1:20 to 1:38.

Abstract translation: 本发明涉及一种蒸汽熨烫装置（1），包括供水装置（4），用于产生蒸汽的蒸汽发生器（6），用于加热蒸汽发生器的加热装置（13），至少一个雾化装置 ），设置在蒸汽发生器和雾化装置之间的流路（9）中的阀（11）和用于将水从所述供水装置输送到所述蒸汽发生器的电动泵（5）。 为了在雾化装置获得湿蒸汽，熨烫装置包括用于控制蒸汽发生器的加热装置（13）的功率的控制装置（7），用于控制泵的流量，并且用于控制泵的打开和关闭 所述阀，如果泵的流量（g / min）与加热装置的功率（W）之间的比率在1:20至1:38的范围内，则阀门打开。

公开(公告)号：US20100104551A1

公开(公告)日：2010-04-29

申请号：US12603988

申请日：2009-10-22

Applicant: Dharmendra M. Jani ,  Kai Kwok ,  Gregory L. McIntire ,  Bruce A. Pfeffer ,  Afshin Shafiee ,  Ruiwen Shi ,  Srini Venkatesh ,  Hongna Wang ,  Yan Huang ,  Stephen R. Davio

Inventor： Dharmendra M. Jani ,  Kai Kwok ,  Gregory L. McIntire ,  Bruce A. Pfeffer ,  Afshin Shafiee ,  Ruiwen Shi ,  Srini Venkatesh ,  Hongna Wang ,  Yan Huang ,  Stephen R. Davio

IPC: A61K38/48 ,  A61P27/02

CPC classification number: C12N9/50 ,  A61K31/198 ,  C12N9/6435 ,  C12N9/96 ,  C12Y304/21007

Abstract: A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.

Abstract translation: 长效酶的组合物包含在包含缓冲液和添加剂的制剂中的酶，所述缓冲剂和添加剂选自氨甲环酸，氨基己酸和除了氨甲环酸以外的L-赖氨酸和β-氨基己酸 酸，其组合，及其混合物。 所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA​​，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。 用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。 该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。 在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

公开(公告)号：US20080095754A1

公开(公告)日：2008-04-24

申请号：US11854608

申请日：2007-09-13

Applicant: Susan E. Burke ,  Erning Xia ,  Kai Kwok ,  Stephen R. Davio

Inventor： Susan E. Burke ,  Erning Xia ,  Kai Kwok ,  Stephen R. Davio

IPC: A61K31/195 ,  A61K38/40 ,  A61K38/47 ,  A61P27/04 ,  C11D3/48

CPC classification number: A61K31/194 ,  A61K9/0048 ,  A61K9/08 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  C11D3/0078 ,  C11D3/33 ,  C11D7/3245

Abstract: An ophthalmic composition that includes an epithelium cell stabilizer component. The epithelium cell stabilizer component may be one or more of diglycine, triglycine, tetraglycine, pentaglycine. The invention is also directed to a method of treating or preventing dry eye comprising administering an effective amount of the ophthalmic composition to the eye.

Abstract translation: 一种眼科组合物，其包含上皮细胞稳定剂成分。 上皮细胞稳定剂组分可以是二甘氨酸，三甘氨酸，四甘氨酸，五聚肌氨酸中的一种或多种。 本发明还涉及治疗或预防干眼症的方法，包括向眼睛施用有效量的眼用组合物。

公开(公告)号：US20060186112A1

公开(公告)日：2006-08-24

申请号：US10566553

申请日：2004-07-22

Applicant: Mokankumar Valiyambath Krishnan ,  Kai Kwok ,  Gerard Cnossen

Inventor： Mokankumar Valiyambath Krishnan ,  Kai Kwok ,  Gerard Cnossen

IPC: H05B1/02

CPC classification number: H05B1/0213 ,  D06F75/26 ,  H05B1/0269

Abstract: An electric heating structure of a domestic appliance includes at least one first electric heating track (23) having a positive temperature coefficient and at least one additional electric heating track (27, 28). A control structure (22, 25, 29) is provided for controlling electric power supply to said first and additional heating tracks (23, 27, 28) and is sensitive to the heating of said at least one first heating track (23) for switching on said at least one additional electric heating track (27, 28) in parallel and in addition to said at least one first heating track (23) when said at least one first heating track (23) has been heated to at least a predetermined extent.

Abstract translation: 家用电器的电加热结构包括至少一个具有正温度系数的第一电加热轨道（23）和至少一个附加电加热轨道（27,28）。 提供控制结构（22,25,29），用于控制对所述第一和另外的加热轨道（23,27,28）的电力供应，并且对所述至少一个第一加热轨道（23）的加热敏感，用于切换 在所述至少一个附加电加热轨道（27,28）上并联并且当所述至少一个第一加热轨道（23）已经被加热到至少预定的程度时，除了所述至少一个第一加热轨道（23） 。

公开(公告)号：US4074727A

公开(公告)日：1978-02-21

申请号：US690660

申请日：1976-05-27

Applicant: Clyde Chi Kai Kwok ,  Joseph Rene Cornellier

Inventor： Clyde Chi Kai Kwok ,  Joseph Rene Cornellier

IPC: D03D47/32 ,  D03D47/30

CPC classification number: D03D47/32

Abstract: A liquid supply system and a nozzle construction for a jet weaving loom. The nozzle is supplied directly from a public water works at the normal pressure of said water works. The exact amount of water required to propel the weft yarn across the open harness shed of the loom is obtained by a solenoid valve series-connected to the water supply adjacent the nozzle and controlled by an electric pulsator which is adjustable to open the valve for the required time in accordance with the width of the weaving and the type of weft yarn. Synchronization of the operation of the nozzle with the harness motion is obtained by a switch controlling the pulsator and directly operated by a cam connected to a shaft of the main movement of the weaving loom. The nozzle structure comprises only two parts: namely, a bored body having a main cylindrical bore portion followed by a tapered frusto-conical bore portion, in turn followed by a cylindrical terminal outlet bore portion and a needle axially adjustable within the body bore, defining an annular space with the latter and having a slightly tapered terminal end fitted within the outlet bore portion of the body. The needle has an axial passage for the yarn. The water is admitted laterally within the body directly into the annular space. The nozzle is able to propel the yarn at a considerable distance with a minimum quantity of liquid and at a low liquid pressure. There is minimum deviation and dispersion of the liquid jet across the harness shed.

Abstract translation: 液体供应系统和喷气织机的喷嘴结构。 喷嘴直接从公用水厂在所述水厂的正常压力下供应。 将纬纱推进织机的开放式线束棚所需的精确水量通过电磁阀获得，该电磁阀串联连接到喷嘴附近的水源，并由电脉动器控制，该电脉动器可调节以打开阀门 根据织造的宽度和纬纱的类型需要时间。 通过开关控制波轮并直接由连接到织机主运动轴上的凸轮操作来获得喷嘴的操作与线束运动的同步。 喷嘴结构仅包括两个部分，即，具有主圆柱形孔部分，随后是锥形截头圆锥形孔部分的钻孔体，随后是圆柱形终端出口孔部分和在体孔内可轴向调节的针，其限定 具有后者的环形空间并且具有装配在主体的出口孔部分内的稍微锥形的端部。 针具有用于纱线的轴向通道。 水体在体内横向容纳在环形空间内。 喷嘴能够以最小量的液体和低液压推动纱线相当远的距离。 液体射流穿过线束棚的最小偏差和分散。