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    Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
    2.
    发明授权
    Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid 有权
    具有两性表面活性剂和透明质酸的眼科组合物

    公开(公告)号：US08119112B2

    公开(公告)日：2012-02-21

    申请号：US12203384

    申请日：2008-09-03

    申请人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki Barniak

    发明人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki Barniak

    IPC分类号： A61K31/74

    CPC分类号： C11D3/48 ,  A01N33/12 ,  A01N47/44 ,  A61K9/0048 ,  A61K31/155 ,  A61K31/728 ,  A61K45/06 ,  A61L12/14 ,  A61L12/141 ,  A61L12/142 ,  A61L12/143 ,  C11D1/88 ,  C11D1/92 ,  C11D3/0078 ,  C11D3/227 ,  C11D3/26 ,  Y10S514/912 ,  A01N25/30 ,  A01N2300/00 ,  A61K2300/00

    摘要： Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 0.15 wt. % of hyaluronic acid; and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

    摘要翻译： 包含0.1ppm至10ppm的选自双胍类，聚合双胍，季铵化合物及其任何混合物的阳离子抗微生物组分的眼用组合物; 0.005重量％ ％〜0.15wt。 ％的透明质酸; 和0.01重量％ ％〜1.0wt ％的通式I的两性表面活性剂，其中R 1是R或 - （CH 2）n -NHC（O）R，其中R是任选被羟基取代的C 8 -C 16烷基，n是2,3或4; R2和R3各自独立地选自甲基，乙基，丙基或异丙​​基; 并且R 4是任选被羟基取代的C 2 -C 8亚烷基。 本发明还直接涉及使用眼用组合物来清洁和消毒隐形眼镜，特别是柔软的硅酮水凝胶隐形眼镜。

    Lens care solutions comprising alkyldimonium hydroxypropyl alkylglucosides
    6.
    发明授权
    Lens care solutions comprising alkyldimonium hydroxypropyl alkylglucosides 有权
    包含烷基二甲基羟丙基烷基葡糖苷的镜片护理溶液

    公开(公告)号：US07632794B1

    公开(公告)日：2009-12-15

    申请号：US12235171

    申请日：2008-09-22

    申请人： Erning Xia ,  Kimberly Millard ,  Srini Venkatesh

    发明人： Erning Xia ,  Kimberly Millard ,  Srini Venkatesh

    IPC分类号： C11D3/22 ,  C11D1/88 ,  C11D3/37 ,  A61L2/18

    CPC分类号： A01N43/16 ,  C11D1/62 ,  C11D3/0078 ,  C11D3/48

    摘要： A contact lens care solution comprising one or more alkyldimonium hydroxypropyl alkylglucosides of general formula I or general formula II wherein R is a straight or branched C8-C24alkyl; A is —CH2CH(OH)CH2N+(CH3)2R1X−, wherein R1 is a C8-C24alkyl and X− is a common counteranion, n is an average value from 1 to 6 and m is an average value from 1 to 2. The solution is formulated to clean and disinfect contact lenses or the solution is formulated as a rewet eye drop for use with contact lenses.

    摘要翻译： 一种隐形眼镜护理溶液，其包含一种或多种通式I或通式II的烷基二甲基羟丙基烷基葡糖苷，其中R是直链或支链C 8 -C 24烷基; A是-CH 2 CH（OH）CH 2 N +（CH 3）2 R 1 X-，其中R 1是C 8 -C 24烷基，X是通常的抗衡阴离子，n是1至6的平均值，m是1至2的平均值。 配制溶液以对隐形眼镜进行清洁和消毒，或将溶液配制为用于隐形眼镜的再润湿滴眼剂。

    Ophthalmic solution with a flavoring agent
    9.
    发明申请
    Ophthalmic solution with a flavoring agent 审中-公开
    具有调味剂的眼科溶液

    公开(公告)号：US20060292188A1

    公开(公告)日：2006-12-28

    申请号：US11431949

    申请日：2006-05-11

    申请人： Joseph Salamone ,  Erning Xia

    发明人： Joseph Salamone ,  Erning Xia

    IPC分类号： A61K9/00

    CPC分类号： A61K31/415 ,  A61K9/0048 ,  A61K31/00 ,  A61K31/4402 ,  A61K31/498 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/44 ,  A61L12/14

    摘要： The invention provides an ophthalmic solution with at least one flavoring agent to mask flavors in the solution or add flavor to the solution. The flavoring agent can be a sweet flavoring agent (sweetener), or combinations of a sweetener with a sour flavoring agent or a bitter flavoring agent or mixtures thereof. The flavoring agent may also be natural flavors, natural fruit flavors, artificial flavors, artificial fruit flavors, flavor enhancers and mixtures thereof, which may be combined with a sweetener, a sour flavoring agent, a bitter flavoring agent, and mixtures thereof. The invention may be utilized as a contact lens solution, an eye drop formulation, and a pharmaceutical composition containing at least one active pharmaceutical ingredient for the treatment of eye diseases.

    摘要翻译： 本发明提供了一种具有至少一种调味剂的眼用溶液，以掩盖溶液中的味道或向溶液中添加风味。 调味剂可以是甜味调味剂（甜味剂）或甜味剂与酸味调味剂或苦味调味剂或其混合物的组合。 调味剂还可以是天然香料，天然水果香料，人造香料，人造水果香料，风味增强剂及其混合物，其可与甜味剂，酸味调味剂，苦味调味剂及其混合物组合。 本发明可以用作隐形眼镜溶液，滴眼剂制剂和含有至少一种用于治疗眼部疾病的活性药物成分的药物组合物。

    Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
    10.
    发明申请
    Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy 审中-公开
    包含类固醇和环孢素的眼科组合物用于干眼疗法

    公开(公告)号：US20060148686A1

    公开(公告)日：2006-07-06

    申请号：US11311534

    申请日：2005-12-19

    申请人： Erning Xia ,  Zhenze Hu ,  Praveen Tyle ,  Stephen Bartels

    发明人： Erning Xia ,  Zhenze Hu ,  Praveen Tyle ,  Stephen Bartels

    IPC分类号： A61K38/13 ,  A61K31/573

    CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K31/56 ,  A61K31/573 ,  A61K2300/00

    摘要： The invention comprises a method of treating dry eye in a patient in need of such treatment. The treatment comprises administering to a patient in need thereof an ophthalmic pharmaceutical composition comprising a corticosteroid and cyclosporine. In a further embodiment of the invention the corticosteroid is loteprednol etabonate. In yet a further embodiment of the invention the cyclosporine is present in the ophthalmic composition as either a natural or synthetic cyclosporine.

    摘要翻译： 本发明包括在需要这种治疗的患者中治疗干眼症的方法。 该治疗包括向有需要的患者施用包含皮质类固醇和环孢霉素的眼用药物组合物。 在本发明的另一个实施方案中，皮质类固醇是苯巴比妥酯。 在本发明的另一个实施方案中，环孢菌素作为天然或合成的环孢菌素存在于眼用组合物中。