公开(公告)号：US20050123609A1

公开(公告)日：2005-06-09

申请号：US11041474

申请日：2005-01-24

申请人： Jane Hirsh ,  Kamal Midha ,  Mark Hirsh ,  Whe-Yong Lo

发明人： Jane Hirsh ,  Kamal Midha ,  Mark Hirsh ,  Whe-Yong Lo

IPC分类号： A61J3/10 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/26 ,  A61K9/30 ,  A61K9/36 ,  A61K9/42 ,  A61K45/00 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/44 ,  A61P9/00 ,  A61P19/00 ,  A61P25/00 ,  A61P37/00 ,  A61K9/20

CPC分类号： A61K9/209 ,  A61K9/0056

摘要： New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient, which comprises: (a) as a first portion, at least one discrete molded triturate tablet comprising a therapeutically effective amount of at least one pharmaceutically active ingredient capable of intraoral administration; and (b) as a second portion located around the said first portion, a therapeutically effective amount of at least one pharmaceutically active ingredient capable of oral administration and which is releasable and orally ingestible by the patient after the molded triturate tablet has disintegrated or has dissolved intraorally.

摘要翻译： 公开了单位剂量形式的新的药物组合物，用于向患者进行口内和口服给药，所述单位剂型被配置为置于所述患者的口内，其包括：（a）作为第一部分，至少一个离散的模制成型的片剂 包括治疗有效量的至少一种能口内给药的药物活性成分; 和（b）作为位于所述第一部分周围的第二部分，治疗有效量的至少一种能够口服给药的药物活性成分，并且其在模制的沙粒片已经崩解或溶解之后由患者可释放和口服摄入 口语

公开(公告)号：US06863901B2

公开(公告)日：2005-03-08

申请号：US10015930

申请日：2001-11-30

申请人： Jane Hirsh ,  Kamal Midha ,  Mark Hirsh ,  Whe-Yong Lo

发明人： Jane Hirsh ,  Kamal Midha ,  Mark Hirsh ,  Whe-Yong Lo

IPC分类号： A61J3/10 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/26 ,  A61K9/30 ,  A61K9/36 ,  A61K9/42 ,  A61K45/00 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/44 ,  A61P9/00 ,  A61P19/00 ,  A61P25/00 ,  A61P37/00 ,  A61K9/20 ,  A61K9/46

CPC分类号： A61K9/209 ,  A61K9/0056

摘要： New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient, which comprises: (a) as a first portion, at least one discrete molded triturate tablet comprising a therapeutically effective amount of at least one pharmaceutically active ingredient capable of intraoral administration; and (b) as a second portion located around the said first portion, a therapeutically effective amount of at least one pharmaceutically active ingredient capable of oral administration and which is releasable and orally ingestible by the patient after the molded triturate tablet has disintegrated or has dissolved intraorally.

摘要翻译： 公开了单位剂量形式的新的药物组合物，用于向患者进行口内和口服给药，所述单位剂型被配置为置于所述患者的口内，其包括：（a）作为第一部分，至少一个离散的模制成型的片剂 包括治疗有效量的至少一种能口内给药的药物活性成分; 和（b）作为位于所述第一部分周围的第二部分，治疗有效量的至少一种能够口服给药的药学活性成分，并且其在模制的特定片剂崩解或溶解之后由患者可释放和口服摄入 口语