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公开(公告)号:US20080114193A1
公开(公告)日:2008-05-15
申请号:US11985381
申请日:2007-11-15
IPC分类号: C07C31/34
CPC分类号: C07C29/095 , C07C67/11 , C07C303/24 , C07D301/26 , C07D303/08 , C07C69/003 , C07C305/08 , C07C69/63 , C07C31/34
摘要: The invention includes methods for preparing halohydrins and epoxides. A method of preparing halohydrins can include exposing (R1CHXCH2O—)2SO2 to R2COOH to produce R2COOCH2CHXR1 and hydrolyzing the R2COOCH2CHXR1 to produce the halohydrin R1CHXCH2OH. R1 and R2 can be the same or different single elements and/or organic groups and X can be a halogen. A method of preparing an epoxide can include combining a sulfuric acid containing solution with a halogen to produce a first mixture and exposing the first mixture to trifluoropropene to produce a second mixture. The second mixture can be combined with acetic acid to produce an acetyl halohydrin of trifluoropropene and the acetyl halohydrin can be hydrolyzed to form a halohydrin of trifluoropropene. The halohydrin can be converted to a trifluoropropyl epoxide.
摘要翻译: 本发明包括制备卤代醇和环氧化物的方法。 制备卤代醇的方法可以包括将(R 1)CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 R 2, SUP> 2 COOH以产生R 2 COOCH 2 CHXR 1,并水解R 2 COOCH 2 CHXR 1以制备卤代醇R 1 CH 2 CH 2 OH。 R 1和R 2可以是相同或不同的单元素和/或有机基团,X可以是卤素。 制备环氧化物的方法可以包括将含硫酸的溶液与卤素组合以产生第一混合物,并将第一混合物暴露于三氟丙烯以产生第二混合物。 第二混合物可以与乙酸组合以产生三氟丙烯的乙酰基卤代醇,并且可以水解乙酰基卤代醇以形成三氟丙烯的卤代醇。 卤代醇可以转化为三氟丙基环氧化物。
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公开(公告)号:US08440830B2
公开(公告)日:2013-05-14
申请号:US12678806
申请日:2008-09-19
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
IPC分类号: C07D471/04 , A61K31/4355 , A61K31/4365 , A61K31/4353 , A61K31/437
CPC分类号: C07D513/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.
摘要翻译: 式(I)化合物,其中环D和环E一起形成选自式(II),(III),(IV),(V),(VI),(VII) 的这些化合物是组蛋白脱乙酰酶的新颖有效的抑制剂。
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3.
公开(公告)号:US20110021494A1
公开(公告)日:2011-01-27
申请号:US12678806
申请日:2008-09-19
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/437 , A61K31/4355 , C07D471/04 , C07D513/04 , C07D498/04 , A61P29/00 , A61K31/4365 , A61P35/04 , A61P37/00
CPC分类号: C07D513/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.
摘要翻译: 式(I)化合物,其中环D和环E一起形成选自式(II),(III),(IV),(V),(VI),(VII) 的这些化合物是组蛋白脱乙酰酶的新颖有效的抑制剂。
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