公开(公告)号：US4313947A

公开(公告)日：1982-02-02

申请号：US58467

申请日：1979-07-18

申请人： Kamuyuki Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

发明人： Kamuyuki Nakagawa ,  Minoru Uchida ,  Kimiaki Oka

IPC分类号： C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D209/04

CPC分类号： C07D215/227 ,  C07D209/34 ,  C07D215/26

摘要： 2-oxyindole derivatives represented by the following general formula: ##STR1## where R.sub.1 is selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, benzyl and phenethyl; A is --CH.dbd.CH-- or ##STR2## wherein R.sub.2 or R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1-4 alkyl; R.sub.6 and R.sub.7 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1-4 alkyl, benzyl, phenethyl and together with the nitrogen atom, a heterocyclic group selected from the group consisting of a piperidino, morpholino, piperazino or thiazolino group; and m and n each are zero or a positive integer with m+n being no more than 11. The 2-oxyindole derivatives have excellent effects on the inhibition of platelet aggregation.

摘要翻译： 由下列通式表示的2-氧吲哚衍生物：其中R 1选自氢，C 1-4烷基，C 2-4链烯基，苄基和苯乙基; A是-CH = CH-或其中R 2或R 3可以相同或不同，并且选自氢和C 1-4烷基; R 6和R 7可以相同或不同，并且选自氢，C 1-4烷基，苄基，苯乙基和氮原子，选自哌啶子基，吗啉代，哌嗪基或 噻唑啉基; m和n各自为零或m + n不大于11的正整数。2-氧吲哚衍生物对抑制血小板聚集具有优异的效果。