公开(公告)号：US06916822B2

公开(公告)日：2005-07-12

申请号：US10203617

申请日：2001-02-16

申请人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

发明人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

IPC分类号： A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536 ,  C07D211/14 ,  A61K31/5747 ,  C07D471/10 ,  A61K31/1438

CPC分类号： C07D211/14 ,  A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536

摘要： A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI), “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group which may be substituted and the like, R4 represents a hydrogen atom, a lower alkyl group which may be substituted and the like, R5 represents a hydrogen atom, a halogen atom and the like, R6 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and R5 and R6, R7 and R8, R9 and R10, or R11 and R12 may bind to each other to form a cyclic structure.

摘要翻译： 用于预防和/或治疗神经系统疾病的药物，其包含作为活性成分的由以下通式（I）表示的化合物或其药理学上可接受的盐：其中，X表示下述 通式（II），（III），（IV），（V）或（VI）中，“A”表示饱和或不饱和的3至6元碳环基等，“B”表示CH _{2 等，“n”表示0〜2，R 1表示氢原子，卤素原子等，R 2，R R 3和R 7相对于R 14代表氢原子，可被取代的低级烷基等，R“ 4表示氢原子，可被取代的低级烷基等，R 5表示氢原子，卤素原子等，R 6， SUP>表示饱和或不饱和的单环或双环碳环基团 R 5和R 6，R 7和R 8，R 9， R 10和R 10，或R 11和R 12可以彼此结合形成环状结构。}

公开(公告)号：US20050148583A1

公开(公告)日：2005-07-07

申请号：US11068759

申请日：2005-03-02

申请人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

发明人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

IPC分类号： A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536 ,  C07D211/14 ,  A61K31/538 ,  C07D413/02 ,  C07D43/02

CPC分类号： C07D211/14 ,  A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536

摘要： A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI), “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group which may be substituted and the like, R4 represents a hydrogen atom, a lower alkyl group which may be substituted and the like, R5 represents a hydrogen atom, a halogen atom and the like, R6 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and R5 and R6, R7 and R8, R9 and R10, or R11 and R12 may bind to each other to form a cyclic structure.

摘要翻译： 用于预防和/或治疗神经系统疾病的药物，其包含作为活性成分的由以下通式（I）表示的化合物或其药理学上可接受的盐：其中，X表示下述 通式（II），（III），（IV），（V）或（VI）中，“A”表示饱和或不饱和的3至6元碳环基等，“B”表示CH _{2 等，“n”表示0〜2，R 1表示氢原子，卤素原子等，R 2，R R 3和R 7相对于R 14代表氢原子，可被取代的低级烷基等，R“ 4表示氢原子，可被取代的低级烷基等，R 5表示氢原子，卤素原子等，R 6， SUP>表示饱和或不饱和的单环或双环碳环基团 R 5和R 6，R 7和R 8，R 9， R 10和R 10，或R 11和R 12可以彼此结合形成环状结构。}

公开(公告)号：US06790854B2

公开(公告)日：2004-09-14

申请号：US10221172

申请日：2003-03-13

申请人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Toshiaki Kudo

发明人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Toshiaki Kudo

IPC分类号： A61K31438

CPC分类号： C07D211/32

摘要： A substance having affinity for an opioid &dgr; receptor, which is represented by the following general formula (I): wherein, X represents a group of the general formula: —CO—N(R5)(R6) (II) and the like, n represents 1 to 3, R1 and R2 represent a hydrogen atom, a halogen atom, a lower alkyl group and the like, R3 represents a hydrogen atom, a halogen atom, a lower alkyl group and the like, R4 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, R5 to R12 represent a hydrogen atom, a lower alkyl group and the like, and R3 and R4, R5 and R6, R7 or R8 and R9 and R10 may bind to each other to form a cyclic structure, and a medicament useful for preventive and/or therapeutic treatment of central nervous system diseases and peripheral nervous system diseases comprising the substance as an active ingredient.

摘要翻译： 由以下通式（I）表示的对阿片样物质δ受体有亲和力的物质：其中，X表示通式-CO-N（R 5）（R 6）（R 6） II）等，n表示1〜3，R 1，R 2表示氢原子，卤素原子，低级烷基等，R 3表示氢原子，卤素原子 ，低级烷基等，R 4表示饱和或不饱和的单环或双环碳环基等，R 5至R 12表示氢原子，低级烷基等，和 R 3和R 4，R 5和R 6，R 7或R 8和R 9和R 10可以彼此结合形成环状结构， 以及可用于预防和/或治疗中枢神经系统疾病和包含该物质作为活性成分的周围神经系统疾病的药物。