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14 条记录 (耗时 0.019 秒)

    Cephalosporin derivative
    1.
    发明授权
    Cephalosporin derivative 失效
    头孢菌素衍生物

    公开(公告)号：US5607927A

    公开(公告)日：1997-03-04

    申请号：US385363

    申请日：1995-02-07

    申请人： Masaki Tsushima ,  Katsuyoshi Iwamatsu ,  Atsushi Tamura ,  Seiji Shibahara

    发明人： Masaki Tsushima ,  Katsuyoshi Iwamatsu ,  Atsushi Tamura ,  Seiji Shibahara

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/59 ,  C07D519/00 ,  C07D519/06 ,  C07D501/36

    CPC分类号： C07D501/00 ,  Y02P20/55

    摘要： An aminothiazolyl- or aminothiadiazolyl-cephalosporin derivative represented by the following general formula (I) which has a condensed-ring thio group as a 3-positioned substituent group that contains a thiazolylthio group, an oxazolylthio group or a heterocyclic ring thereof as one of the ring components. The compound according to the present invention has excellent activities to inhibit growth of various bacteria, especially Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), and therefore, the antibacterial agent comprising, as an active ingredient, the inventive compound can be used as a therapeutic drug for the treatment of various bacterial infections. ##STR1##

    摘要翻译： 作为下述通式（I）表示的氨基噻唑基 - 或氨基噻二唑基 - 头孢菌素衍生物，其具有稠环硫基作为含有噻唑基硫基，恶唑基硫基或其杂环的3位取代基 环组件。 根据本发明的化合物具有优异的抑制各种细菌，特别是耐甲氧西林金黄色葡萄球菌（MRSA）的革兰氏阳性菌生长的活性，因此作为本发明化合物作为活性成分的抗菌剂可以是 用作治疗各种细菌感染的治疗药物。

    Phenoxyalkylamine derivatives useful as opioid delta receptor ligands
    5.
    发明申请
    Phenoxyalkylamine derivatives useful as opioid delta receptor ligands 审中-公开
    可用作阿片样物质δ受体配体的苯氧基烷基胺衍生物

    公开(公告)号：US20050148583A1

    公开(公告)日：2005-07-07

    申请号：US11068759

    申请日：2005-03-02

    申请人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

    发明人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

    IPC分类号： A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536 ,  C07D211/14 ,  A61K31/538 ,  C07D413/02 ,  C07D43/02

    CPC分类号： C07D211/14 ,  A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536

    摘要： A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI), “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group which may be substituted and the like, R4 represents a hydrogen atom, a lower alkyl group which may be substituted and the like, R5 represents a hydrogen atom, a halogen atom and the like, R6 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and R5 and R6, R7 and R8, R9 and R10, or R11 and R12 may bind to each other to form a cyclic structure.

    摘要翻译： 用于预防和/或治疗神经系统疾病的药物，其包含作为活性成分的由以下通式（I）表示的化合物或其药理学上可接受的盐：其中，X表示下述 通式（II），（III），（IV），（V）或（VI）中，“A”表示饱和或不饱和的3至6元碳环基等，“B”表示CH 2 等，“n”表示0〜2，R 1表示氢原子，卤素原子等，R 2，R R 3和R 7相对于R 14代表氢原子，可被取代的低级烷基等，R“ 4表示氢原子，可被取代的低级烷基等，R 5表示氢原子，卤素原子等，R 6， SUP>表示饱和或不饱和的单环或双环碳环基团 R 5和R 6，R 7和R 8，R 9， R 10和R 10，或R 11和R 12可以彼此结合形成环状结构。

    Diphenylalkylamine derivatives useful as opioid receptor agonists
    6.
    发明授权
    Diphenylalkylamine derivatives useful as opioid receptor agonists 失效
    用作阿片类受体激动剂的二苯基烷基胺衍生物

    公开(公告)号：US06790854B2

    公开(公告)日：2004-09-14

    申请号：US10221172

    申请日：2003-03-13

    申请人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Toshiaki Kudo

    发明人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Toshiaki Kudo

    IPC分类号： A61K31438

    CPC分类号： C07D211/32

    摘要： A substance having affinity for an opioid &dgr; receptor, which is represented by the following general formula (I): wherein, X represents a group of the general formula: —CO—N(R5)(R6) (II) and the like, n represents 1 to 3, R1 and R2 represent a hydrogen atom, a halogen atom, a lower alkyl group and the like, R3 represents a hydrogen atom, a halogen atom, a lower alkyl group and the like, R4 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, R5 to R12 represent a hydrogen atom, a lower alkyl group and the like, and R3 and R4, R5 and R6, R7 or R8 and R9 and R10 may bind to each other to form a cyclic structure, and a medicament useful for preventive and/or therapeutic treatment of central nervous system diseases and peripheral nervous system diseases comprising the substance as an active ingredient.

    摘要翻译： 由以下通式（I）表示的对阿片样物质δ受体有亲和力的物质：其中，X表示通式-CO-N（R 5）（R 6）（R 6） II）等，n表示1〜3，R 1，R 2表示氢原子，卤素原子，低级烷基等，R 3表示氢原子，卤素原子 ，低级烷基等，R 4表示饱和或不饱和的单环或双环碳环基等，R 5至R 12表示氢原子，低级烷基等，和 R 3和R 4，R 5和R 6，R 7或R 8和R 9和R 10可以彼此结合形成环状结构， 以及可用于预防和/或治疗中枢神经系统疾病和包含该物质作为活性成分的周围神经系统疾病的药物。

    Phenoxyalkylamine derivatives useful as opioid δ receptor agonists
    10.
    发明授权
    Phenoxyalkylamine derivatives useful as opioid δ receptor agonists 失效
    用作阿片样物质δ受体激动剂的苯氧基烷基胺衍生物

    公开(公告)号：US06916822B2

    公开(公告)日：2005-07-12

    申请号：US10203617

    申请日：2001-02-16

    申请人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

    发明人： Masaki Tsushima ,  Kaori Tadauchi ,  Kenji Asai ,  Naoko Miike ,  Masako Imai ,  Toshiaki Kudo

    IPC分类号： A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536 ,  C07D211/14 ,  A61K31/5747 ,  C07D471/10 ,  A61K31/1438

    CPC分类号： C07D211/14 ,  A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/536

    摘要： A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI), “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group which may be substituted and the like, R4 represents a hydrogen atom, a lower alkyl group which may be substituted and the like, R5 represents a hydrogen atom, a halogen atom and the like, R6 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and R5 and R6, R7 and R8, R9 and R10, or R11 and R12 may bind to each other to form a cyclic structure.

    摘要翻译： 用于预防和/或治疗神经系统疾病的药物，其包含作为活性成分的由以下通式（I）表示的化合物或其药理学上可接受的盐：其中，X表示下述 通式（II），（III），（IV），（V）或（VI）中，“A”表示饱和或不饱和的3至6元碳环基等，“B”表示CH 2 等，“n”表示0〜2，R 1表示氢原子，卤素原子等，R 2，R R 3和R 7相对于R 14代表氢原子，可被取代的低级烷基等，R“ 4表示氢原子，可被取代的低级烷基等，R 5表示氢原子，卤素原子等，R 6， SUP>表示饱和或不饱和的单环或双环碳环基团 R 5和R 6，R 7和R 8，R 9， R 10和R 10，或R 11和R 12可以彼此结合形成环状结构。